Hyaluronic acid-gold nanoparticle/interferon α complex for targeted treatment of hepatitis C virus infection

ACS Nano

Volumn 6, Issue 11, 2012, Pages 9522-9531

  Lee, Min Young ^a   Yang, Jeong A ^a   Jung, Ho Sang ^a   Beack, Songeun ^a   Choi, Jung Eun ^b   Hur, Wonhee ^b   Koo, Heebeom ^c   Kim, Kwangmeyung ^c   Yoon, Seung Kew ^b   Hahn, Sei Kwang ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

gold nanoparticle; hepatitis C virus; hyaluronic acid; interferon R; targeted delivery

Indexed keywords

BIOPHARMACEUTICALS; CHEMICAL BINDING; CLINICAL TREATMENTS; DAUDI CELLS; DELIVERY SYSTEMS; ENHANCED STABILITY; GOLD NANOPARTICLE; GOLD NANOPARTICLES; HEPATITIS C VIRUS; HUMAN SERUM; HYALURONIC ACIDS; INNATE IMMUNE RESPONSE; LIVER TISSUE; PHYSICAL BINDING; POSTINJECTION; SYNTHETASES; TARGETED DELIVERY; TARGETED TREATMENT; VIRAL INFECTIONS;

ANTIBIOTICS; BIOACTIVITY; GLYCOPROTEINS; GOLD; HYBRID MATERIALS; METAL NANOPARTICLES; ORGANIC ACIDS; POLYETHYLENE GLYCOLS; TISSUE; VIRUSES;

GOLD COMPOUNDS;

ALPHA INTERFERON; ANTIVIRUS AGENT; GOLD; HYALURONIC ACID; METAL NANOPARTICLE; NANOCAPSULE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CHEMISTRY; HEPATITIS C; MOUSE; PATHOLOGY; TREATMENT OUTCOME;

ANIMALS; ANTIVIRAL AGENTS; GOLD; HEPATITIS C; HYALURONIC ACID; INTERFERON-ALPHA; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; NANOCAPSULES; TREATMENT OUTCOME;

EID: 84870425936     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn302538y     Document Type: Article

References (34)

1. Ghosh, P.; Han, G.; De, M.; Kim, C. K.; Rotello, V. M. Gold Nanoparticles in Delivery Applications Adv. Drug Delivery Rev. 2008, 60, 1307-1315
2. Thakor, A. S.; Jokerst, J.; Zavaleta, C.; Massoud, T. F.; Gambhir, S. S. Gold Nanoparticles: A Revival in Precious Metal Administration to Patients Nano Lett. 2011, 11, 4029-4036
3. Giljohann, D. A.; Seferos, D. S.; Daniel, W. L.; Massich, M. D.; Patel, P. C.; Mirkin, C. A. Gold Nanoparticles for Biology and Medicine Angew. Chem., Int. Ed. 2010, 49, 3280-3294
4. Lee, M. Y.; Park, S. J.; Park, K.; Kim, K. S.; Lee, H.; Hahn, S. K. Target-Specific Gene Silencing of Layer-by-Layer Assembled Gold-Cysteamine/ siRNA/PEI/HA Nanocomplex ACS Nano 2011, 5, 6138-6147
5. Dykman, L.; Khlebtsov, N. Gold Nanoparticles in Biomedical Applications: Recent Advances and Perspectives Chem. Soc. Rev. 2012, 27, 2256-2282
6. Verma, A.; Simard, J. M.; Worrall, J. W.; Rotello, V. M. Tunable Reactivation of Nanoparticle-Inhibited Beta-Galactosidase by Glutathione at Intracellular Concentrations J. Am. Chem. Soc. 2004, 126, 13987-13991
7. Liu, C. L.; Wu, H. T.; Hsiao, Y. H.; Lai, C. W.; Shih, C. W.; Peng, Y. K.; Tang, K. C.; Chang, H. W.; Chien, Y. C.; Hsiao, J. K. et al. Insulin-Directed Synthesis of Fluorescent Gold Nanoclusters: Preservation of Insulin Bioactivity and Versatility in Cell Imaging Angew. Chem., Int. Ed. 2011, 50, 7056-7060
8. Kim, B. Y.; Rutka, J. T.; Chan, W. C. Nanomedicine N. Engl. J. Med. 2010, 363, 2434-2443
9. Paciotti, G. F.; Myer, L.; Weinreich, D.; Goia, D.; Pavel, N.; McLaughlin, R. E.; Tamarkin, L. Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery Drug Delivery 2004, 11, 169-183
10. Huang, L.; Liu, Y. In Vivo Delivery of RNAi with Lipid-Based Nanoparticles Ann. Rev. Biomed. Eng. 2011, 13, 507-530
11. Poon, Z.; Lee, J. B.; Morton, S. W.; Hammond, P. T. Controlling in Vivo Stability and Biodistribution in Electrostatically Assembled Nanoparticles for Systemic Delivery Nano Lett. 2011, 11, 2096-2103
12. Oh, E. J.; Park, K.; Kim, K. S.; Kim, J.; Yang, J. A.; Kong, J. H.; Lee, M. Y.; Hoffman, A. S.; Hahn, S. K. Target Specific and Long-Acting Delivery of Protein, Peptide, and Nucleotide Therapeutics Using Hyaluronic Acid Derivatives J. Controlled Release 2010, 141, 2-12
13. Ito, T.; Iida-Tanaka, N.; Niidome, T.; Kawano, T.; Kubo, K.; Yoshikawa, K.; Sato, T.; Yang, Z.; Koyama, Y. Hyaluronic Acid and its Derivative as a Multi-Functional Gene Expression Enhancer: Protection from Non-Specific Interactions, Adhesion to Targeted Cells, and Transcriptional Activation J. Controlled Release 2006, 112, 382-388
14. Ahrens, T.; Assmann, V.; Fieber, C.; Termeer, C.; Herrlich, P.; Hofmann, M.; Simon, J. C. CD44 is the Principal Mediator of Hyaluronic-Acid-Induced Melanoma Cell Proliferation J. Invest. Dermatol. 2001, 116, 93-101
15. Entwistle, J.; Hall, C. L.; Turley, E. A. HA Receptors: Regulators of Signaling to the Cytoskeleton J. Cell Biochem. 1996, 61, 569-577
16. Zhou, B.; Weigel, J. A.; Fauss, L.; Weigel, P. H. Identification of the Hyaluronan Receptor for Endocytosis (HARE) J. Biol. Chem. 2000, 275, 37733-37741
17. Kim, K. S.; Hur, W.; Park, S. J.; Hong, S. W.; Choi, J. E.; Goh, E. J.; Yoon, S. K.; Hahn, S. K. Bioimaging for Targeted Delivery of Hyaluronic Acid Derivatives to the Livers in Cirrhotic Mice Using Quantum Dots ACS Nano 2010, 4, 3005-3014
18. Yang, J. A.; Park, K.; Jung, H.; Kim, H.; Hong, S. W.; Yoon, S. K.; Hahn, S. K. Target Specific Hyaluronic Acid-Interferon Alpha Conjugate for the Treatment of Hepatitis C Virus Infection Biomaterials 2011, 32, 8722-8729
19. Chevaliez, S.; Pawlotsky, J. M. Interferon-Based Therapy of Hepatitis C Adv. Drug Delivery Rev. 2007, 59, 1222-1241
20. Thitinan, S.; McConville, J. T. Interferon Alpha Delivery Systems for the Treatment of Hepatitis C Int. J. Pharm. 2009, 369, 121-135
21. Cheng, J. C.; Yeh, Y. J.; Huang, Y. H.; Liang, K. H.; Chang, M. L.; Lin, C. Y.; Yeh, C. T. Hepatic Expression of MxA and OAS1 in an Ex Vivo Liver Slice Assay Independently Predicts Treatment Outcomes in Chronic Hepatitis C J. Viral. Hepat. 2012, 19, 154-162
22. Warren, A.; Bertolino, P.; Benseler, V.; Fraser, R.; McCaughan, G. W.; Le Couteur, D. G. Marked Changes of the Hepatic Sinusoid in a Transgenic Mouse Model of Acute Immune-Mediated Hepatitis J. Hepatol. 2007, 46, 239-246
23. Caríllo, M. C.; Alvarez Mde, L.; Quiroga, A. D. Interferon Alfa-2b Triggers Transforming Growth Factor-Beta-Induced Apoptosis on Preneoplasticliver Ann. Hepatol. 2006, 5, 244-250
24. Lee, K.; Lee, H.; Bae, K. H.; Park, T. G. Heparin Immobilized Gold Nanoparticles for Targeted Detection and Apoptotic Death of Metastatic Cancer Cells Biomaterials 2010, 31, 6530-6536
25. Schwarzenbach, M. S.; Reimann, P.; Thommen, V.; Hegner, M.; Mumenthaler, M.; Schwob, J.; Güntherodt, H. J. Interferon Alpha-2a Interactions on Glass Vial Surfaces Measured by Atomic Force Microscopy PDA J. Pharm. Sci. Technol. 2002, 56, 78-89
26. Calzolai, L.; Franchini, F.; Gilliland, D.; Rossi, F. Protein-Nanoparticle Interaction: Identification of the Ubiquitin-Gold nanoparticle Interaction Site Nano Lett. 2010, 10, 3101-3205
27. Mukherjee, P.; Bhattacharya, R.; Bone, N.; Lee, Y. K.; Patra, C. R.; Wang, S.; Lu, L.; Secreto, C.; Banerjee, P. C.; Yaszemski, M. J. et al. Potential Therapeutic Application of Gold Nanoparticles in B-Chronic Lymphocytic Leukemia (BCLL): Enhancing Apoptosis J. Nanobiotechnol. 2007, 5, 4
28. Beilharz, M. W.; Nisbet, I. T.; Tymms, M. J.; Hertzog, P. J.; Linnane, A. W. Antiviral and Antiproliferative Activities of Interferon-Alpha 1: the Role of Cysteine Residues J. Interferon Res. 1986, 6, 677-685
29. Lacerda, S. H.; Park, J. J.; Meuse, C.; Pristinski, D.; Becker, M. L.; Karim, A.; Douglas, J. F. Interaction of Gold Nanoparticles with Common Human Blood Proteins ACS Nano 2010, 4, 365-379
30. Tsai, D. H.; Delrio, F. W.; Keene, A. M.; Tyner, K. M.; Maccuspie, R. I.; Cho, T. J.; Zachariah, M. R.; Hackley, V. A. Adsorption and Conformation of Serum Albumin Protein on Gold Nanoparticles Investigated Using Dimensional Measurements and in Situ Spectroscopic Methods Langmuir 2011, 27, 2464-2477
31. Slocik, J. M.; Govorov, A. O.; Naik, R. R. Plasmonic Circular Dichroism of Peptide-Functionalized Gold Nanoparticles Nano Lett. 2011, 11, 701-705
32. Petricoin, E. F.; Ito, S.; Williams, B. L.; Audet, S.; Stancato, L. F.; Gamero, A.; Clouse, K.; Grimley, P.; Weiss, A.; Beeler, J. Antiproliferative Action of Interferon-Alpha Requires Components of T-Cell-Receptor Signalling Nature 1997, 390, 629-632
33. Lauer, G. M.; Walker, B. D. Hepatitis C Virus Infection N. Engl. J. Med. 2001, 345, 41-52
34. Rebouillat, D.; Hovanessian, A. G. The Human 2′,5′- Oligoadenylate Synthetase Family: Interferon-Induced Proteins with Unique Enzymatic Properties J. Interferon Cytokine Res. 1999, 19, 295-308