Principal component analysis of cerebellar shape on MRI separates SCA types 2 and 6 into two archetypal modes of degeneration

Cerebellum

Volumn 11, Issue 4, 2012, Pages 887-895

  Jung, Brian C ^a,b,c   Choi, Soo I ^a,d   Du, Annie X ^g   Cuzzocreo, Jennifer L ^a   Geng, Zhuo Z ^a   Ying, Howard S ^a   Perlman, Susan L ^e   Toga, Arthur W ^e   Prince, Jerry L ^a,f   Ying, Sarah H ^a,g  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Johns Hopkins University   (United States)

^g NONE

Author keywords

Ataxia; Biomarker; Cerebellum; Magnetic resonance imaging (MRI); Principal component analysis (PCA)

Indexed keywords

ADULT; ARTICLE; BRAIN ATROPHY; CEREBELLAR ATAXIA; CEREBELLAR SHAPE; CEREBELLUM ATROPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE CLASSIFICATION; FEMALE; HUMAN; INTERRATER RELIABILITY; MALE; NERVOUS SYSTEM PARAMETERS; NEUROANATOMY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PATHOPHYSIOLOGY; PHENOTYPE; POST HOC ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SECONDARY ANALYSIS; SIGNAL NOISE RATIO; SPINOCEREBELLAR ATAXIA TYPE 2; SPINOCEREBELLAR ATAXIA TYPE 6; SPINOCEREBELLAR DEGENERATION;

EID: 84870419943     PISSN: 14734222     EISSN: 14734230     Source Type: Journal    
DOI: 10.1007/s12311-011-0334-6     Document Type: Article

References (23)

1. Manto M-U, Pandolfo M. The cerebellum and its disorders. Cambridge, UK: Cambridge University; 2002.
2. Perlman S. Evaluation and management of ataxic disorders. An overview for physicians. Minneapolis: National Ataxia Foundation; 2007.
3. Ying SH, Choi SI, Lee M, Perlman SL, Baloh RW, Toga AW, et al. Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6. Ann N Y Acad Sci. 2005;1039:430-5. (Pubitemid 40979900)
4. Jung BC, Choi SI, Du AX, Cuzzocreo JL, Ying HS, Landman BA, et al. MRI shows a region-specific pattern of atrophy in spinocerebellar ataxia type 2. Cerebellum [Internet]. 18 Aug 2011 [cited 11 Oct 2011]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21850525.
5. Subramony SH, May W, Lynch D, Gomez C, Fischbeck K, Hallett M, et al. Measuring Friedreich ataxia: interrater reliability of a neurologic rating scale. Neurology. 2005;64(7):1261-2.
6. Ying SH, Choi SI, Perlman SL, Baloh RW, Zee DS, Toga AW. Pontine and cerebellar atrophy correlate with clinical disability in SCA2. Neurology. 2006;66(3):424-6. (Pubitemid 43739950)
7. Schmahmann JD. MRI atlas of the human cerebellum. San Diego: Academic Press; 2000.
8. Buttner N, Geschwind D, Jen JC, Perlman S, Pulst SM, Baloh RW. Oculomotor phenotypes in autosomal dominant ataxias. Arch Neurol. 1998;55(10):1353-7. (Pubitemid 28465871)
9. Schulz JB, Borkert J, Wolf S, Schmitz-Hübsch T, Rakowicz M, Mariotti C, et al. Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6. Neuroimage. 2010;49(1):158-68.
10. Marzban H, Chung S-H, Pezhouh MK, Feirabend H, Watanabe M, Voogd J, et al. Antigenic compartmentation of the cerebellar cortex in the chicken (Gallus domesticus). J Comp Neurol. 2010;518(12):2221-39.
11. Kawamura K, Hashikawa T. Projections from the pontine nuclei proper and reticular tegmental nucleus onto the cerebellar cortex in the cat. An autoradiographic study. J Comp Neurol. 1981;201 (3):395-413. (Pubitemid 11010911)
12. Voogd J, Barmack NH. Oculomotor cerebellum. Prog Brain Res. 2006;151:231-68. (Pubitemid 41420832)
13. Glickstein M, Gerrits N, Kralj-Hans I, Mercier B, Stein J, Voogd J. Visual pontocerebellar projections in the macaque. J Comp Neurol. 1994;349(1):51-72. (Pubitemid 24328520)
14. Eisenman LM, Noback CR. The ponto-cerebellar projection in the rat: differential projections to sublobules of the uvula. Exp Brain Res. 1980;38(1):11-7. (Pubitemid 10128340)
15. Brodal A, Hoddevik GH. The pontocerebellar projection of the uvula in the cat. Exp Brain Res. 1978;32(1):105-16.
16. Mower G, Gibson A, Robinson F, Stein J, Glickstein M. Visual pontocerebellar projections in the cat. J Neurophysiol. 1980;43 (2):355-66. (Pubitemid 10098366)
17. Gerrits NM, Epema AH, Voogd J. The mossy fiber projection of the nucleus reticularis tegmenti pontis to the flocculus and adjacent ventral paraflocculus in the cat. Neuroscience. 1984;11 (3):627-44. (Pubitemid 14155961)
18. Robinson FR, Cohen JL, May J, Sestokas AK, Glickstein M. Cerebellar targets of visual pontine cells in the cat. J Comp Neurol. 1984;223(4):471-82. (Pubitemid 14165199)
19. Akaogi K. Afferent projections to the nodulus in the cat. II. Mossy fiber projections. Nippon Jibiinkoka Gakkai Kaiho. 1994;97 (1):12-9.
20. Brodal P. Further observations on the cerebellar projections from the pontine nuclei and the nucleus reticularis tegmenti pontis in the rhesus monkey. J Comp Neurol. 1982;204(1):44-55. (Pubitemid 12205692)
21. Liu J, Tang T-S, Tu H, Nelson O, Herndon E, Huynh DP, et al. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci. 2009;29(29):9148-62.
22. Chen X, Tang T-S, Tu H, Nelson O, Pook M, Hammer R, et al. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neurosci. 2008;28(48):12713-24.
23. Rajakulendran S, Schorge S, Kullmann DM, Hanna MG. Dysfunction of the Ca(V)2.1 calcium channel in cerebellar ataxias. F1000 Biol Rep [Internet]. 2010 [cited 1 Jun 2011]; 2. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 20948794.