Clade A HIV-1 gag-specific T cell responses are frequent but do not correlate with viral loads in a cohort of treatment-naïve HIV-infected individuals living in Guinea-Bissau

Clinical and Vaccine Immunology

Volumn 19, Issue 12, 2012, Pages 1999-2001

  Jensen, Kristoffer Jarlov ^a   Román, Victor Raúl Gómez ^a,f   Jensen, Sanne Skov ^a   Leo Hansen, Christian ^a   Karlsson, Ingrid ^a   Katzenstein, Terese Lea ^b   Rodrigues, Candida Medina ^c   Jespersen, Sanne ^d   Janitzek, Christoph Mikkel ^a   Da Silva Té, David ^c   Hayes, Peter ^e   Fomsgaard, Anders ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c Hospital Nacional Simão Mendes HNSM   (Guinea-Bissau)

^d BANDIM HEALTH PROJECT   (Guinea-Bissau)

^e INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^f International Vaccine Institute   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PHYTOHEMAGGLUTININ A; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; CD4 LYMPHOCYTE COUNT; CLADISTICS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; EPIDEMIC; EPSTEIN BARR VIRUS; GROUP SPECIFIC ANTIGEN GENE; GUINEA-BISSAU; HIV 1 GAG SPECIFIC T LYMPHOCYTE; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOREACTIVITY; INFLUENZA VIRUS A; LETTER; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS GENE; VIRUS LOAD; VIRUS STRAIN;

CD4 LYMPHOCYTE COUNT; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENOTYPE; GUINEA-BISSAU; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-GAMMA; T-LYMPHOCYTES; VIRAL LOAD;

EID: 84870414033     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00399-12     Document Type: Letter

References (13)

1. Carr JK, et al. 1998. Full genome sequences of human immunodeficiency virus type 1 subtypes G and A/G intersubtype recombinants. Virology 247:22-31. (Pubitemid 28384022)
2. Chahroudi A, et al. 2005. Measurement of HIV-1 CRF02-AG-specific T cell responses indicates the dominance of a p24(gag) epitope in blood donors in Abidjan, Cote d'Ivoire. J. Infect. Dis. 192:1417-1421. (Pubitemid 41401156)
3. Edwards BH, et al. 2002. Magnitude of functional CD8+ T-cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J. Virol. 76:2298-2305. (Pubitemid 34150698)
4. Esbjornsson J, Mild M, Mansson F, Norrgren H, Medstrand P. 2011. HIV-1 molecular epidemiology in Guinea-Bissau, West Africa: origin, demography and migrations. PLoS One 6:e17025. doi:10.1371/journal.pone.0017025.
5. Fu TM, et al. 2007. Evaluation of cellular immune responses in subjects chronically infected with HIV type 1. AIDS Res. Hum. Retroviruses 23:67-76.
6. Kalinkovich A, et al. 2001. Increased CCR5 and CXCR4 expression in Ethiopians living in Israel: environmental and constitutive factors. Clin. Immunol. 100:107-117.
7. Keefer MC, et al. 2012. A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One 7:e41936. doi:10.1371/journal.pone.0041936.
8. Kemp K, Akanmori BD, Hviid L. 2001. West African donors have high percentages of activated cytokine producing T cells that are prone to apoptosis. Clin. Exp. Immunol. 126:69-75. (Pubitemid 32989494)
9. Koesters SA, et al. 2004. Elevation of immune activation in Kenyan women is associated with alterations in immune function: implications for vaccine development. J. Clin. Immunol. 24:702-709. (Pubitemid 40933122)
10. Messele T, et al. 1999. Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin. Exp. Immunol. 115:443-450. (Pubitemid 29130358)
11. Montavon C, et al. 2000. Most env and gag subtype A HIV-1 viruses circulating in West and West Central Africa are similar to the prototype AG recombinant virus IBNG. J. Acquir. Immune Defic. Syndr. 23:363-374.
12. Moodie Z, et al. 2010. Response definition criteria for ELISPOT assays revisited. Cancer Immunol. Immunother. 59:1489-1501.
13. Tiba F, et al. 2011. Constitutive activation and accelerated maturation of peripheral blood T cells in healthy adults in Burkina Faso compared to Germany: the case of malaria? Eur. J. Med. Res. 16:519-525.