A geometrical approach to the PKPD modelling of inhaled bronchodilators

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 39, Issue 5, 2012, Pages 415-428

  Gaz, Claudio ^a   Cremona, George ^b   Panunzi, Simona ^a   Patterson, Beverley ^c   De Gaetano, Andrea ^a  

^a CNR   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c Novartis Pharmaceutical UK Limited   (United Kingdom)

Author keywords

Bronchodilators; FEV1; Inhalation therapy; Mathematical models; Ventilation

Indexed keywords

BRONCHODILATING AGENT;

ADULT; ANATOMICAL VARIATION; ARTICLE; BRONCHUS MUSCLE; COMPARTMENT MODEL; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; FEMALE; FLOW RATE; FORCED EXPIRATORY VOLUME; GEOMETRY; HUMAN; MALE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEDICAL DECISION MAKING; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MODEL; QUANTITATIVE ANALYSIS; RESPIRATORY AIRFLOW; TRACHEOBRONCHIAL TREE;

ADMINISTRATION, INHALATION; BRONCHODILATOR AGENTS; FORCED EXPIRATORY VOLUME; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PHARMACOKINETICS; RESPIRATORY MUCOSA;

EID: 84870400018     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-012-9259-z     Document Type: Article

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