The discovery and characterization of riboflavin

Annals of Nutrition and Metabolism

Volumn 61, Issue 3, 2012, Pages 224-230

  Northrop Clewes, Christine A ^a,c   Thurnham, David I ^b  

^a Nutrition Consultant   (United Kingdom)

^b UNIVERSITY OF ULSTER   (United Kingdom)

^c NONE   (United Kingdom)

Author keywords

Growth promoting; Lactoflavin; Riboflavin

Indexed keywords

ADENINE; RIBOFLAVIN; THIAMINE; VITAMIN B COMPLEX;

BIOLOGICAL FUNCTIONS; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CLINICAL FEATURE; COENZYME; DRUG DETERMINATION; DRUG ISOLATION; FOOD COMPOSITION; HISTORY; HUMAN; ISOLATION PROCEDURE; MEDICAL RESEARCH; NONHUMAN; PELLAGRA; PRIORITY JOURNAL; REVIEW; RIBOFLAVIN DEFICIENCY;

EID: 84870386078     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000343111     Document Type: Review

References (33)

1. Thurnham DI: Beriberi; in Caballero B, Allen L, Prentice A (eds): Encyclopedia of Human Nutrition, ed 2. Oxford, Elsevier, 2005, pp 269-278.
2. Bates CJ: Human riboflavin requirements, and metabolic consequences of deficiency in man and animals. World Rev Nutr Diet 1987; 50:215-265.
3. 2 history. http://www.vitamin-ba-sics.com/index.php?id=55 (accessed September 10, 2012).
4. Hopkins FG: Feeding experiments illustrating the importance of accessory factors in normal dietaries. J Physiol 1912; 44: 425-460.
5. McCollum EV: The paths to the discovery of v itamins A and D. J Nutr 1967; 91: 11-16.
6. McCollum EV, Davis M: The nature of the dietary deficiencies of rice. J Biol Chem 1915; 23: 181-232.
7. McCollum EV, Davis M: The essential factors in the diet during growth. J Biol Chem 1915; 23: 231-256.
8. McCollum EV, Davis M: The cause of the loss of nutritive efficiency of heated milk. J Biol Chem 1915; 23: 247-254.
9. Goldberger J, Tanner WF: A study of the treatment and prevention of pellagra. Experiments showing the value of fresh meat and milk, the therapeutic failure of gelatin and the preventive failure of butter and of cod liver oil. US Public Health Reports 1924; 39: 87-106.
10. Gyorgy P: Early experiences with riboflavin; a retrospect. Nutr Rev 1954; 12:97-100.
11. Chick H, Roscoe MH: On the composite nature of the water-soluble B vitamin. Biochem J 1927; 21:698-711.
12. 2. Biochem J 1928; 22: 790-799.
13. 2 complex. I. The differentiation of lactoflavin and the 'rat antipellagra' factor. Biochem J 1935; 29:741-759.
14. Chick H, Copping AM: The alcohol-solubility of the anti-dermatitis, more heat-stable vitamin B2 constituent of the vitamin B complex. Biochem J 1930; 24:1744.
15. 6 (so-called 'rat pellagra' factor). Biochem J 1935; 29: 2930-2850.
16. Bourquin A, Sherman HC: Quantitative determination of vitamin G (B2). J Am Chem Soc 1931; 53: 3501.
17. 2 and flavins. J Biol Chem 1935; 108:709-728.
18. Nobelprize.org: Richard Kuhn and the chemical institute: double bonds and biological mechanisms. http://www.nobelprize. org/nobel-prizes/medicine/ articles/states/richard-kuhn.html (accessed September 10, 2012).
19. Kuhn R, Gyorgy P, Wagner-Jauregg T: Über eine neue Klasse von Naturfarbstoffen (Vorläufige Mitteilung). Ber Deutsch Chem Ges 1933; 66:317-312.
20. Kuhn R, Gyorg y P, Wagsta ff L: Ü ber O vof lavin, den Farbstoff des Eiklars. Ber Deutsch Chem Ges 1933; 66: 576-580.
21. Stern KG, Holiday ER: Die Photo-flavine, eine Gruppe von Alloxazin-Derivaten. Ber Deutsch Chem Ges 1934; 67:1442-1452.
22. Stern KG, Holiday ER: Zur Konstitution des Photo-flavins; Versuche in der Alloxazin-Reihe (Vorläufige Mitteilung). Ber Deutsch Chem Ges 1934; 67:1104-1106.
23. Kuhn R, Reinemund K: Über die Synthese des 6.7.9-Trimethyl-flavins (Lumi-lactofla-vins). Ber Deutsch Chem Ges 1934; 67: 1932-1936.
24. 2. Naturwissenschaften 1933;21: 560-561.
25. Karrer P, Schöpp K, Benz F, Pfaehler K: Synthesen von Flavinen III. Helv Chim Acta 1935; 18: 69-79.
26. Warburg O, Christian W: Ein zweites sauerstoffübertragendes Ferment und sein Absorptionsspektrum. Naturwissenschaften 1932; 20: 688.
27. Kuhn R, Rudy H: Katalytische Wirkung der Lactoflavin-5'- phosphorsäure; Synthese des gelben Ferments. Ber Deutsch Chem Ges 1936; 69: 1974-1977.
28. Theorell H: Nobel Prize lecture. http://www. nobelprize.org/nobel-prizes/ medicine/lau-reates/1955/theorell-lecture.pdf (accessed September 10, 2012).
29. Matthews RG, Massey V: Isolation of old yellow enzyme in free and complexed forms. J Biol Chem 1969; 244:1779-1786.
30. Sebrell WH, Butler RE: Riboflavin deficiency in man (ariboflavinosis). US Public Health Reports 1939; 54:2121-2131.
31. Glatzle D, Weber F, Wiss O: Enzymatic test for the detection of a riboflavin deficiency. NADPH-dependent glutathione reductase of red blood cells and its activation by FAD in vitro. Experientia 1968;24:1122.
32. Glatzle D, Körner WF, Christeller S, Wiss O: Method for the detection of biochemical riboflavin deficiency. Stimulation of NADPH2-dependent glutathione reductase from human erythrocytes by FAD in vitro. Int Z Vitaminforsch 1970; 40: 166-183.
33. Thurnham DI, Migasena P, Vudhivai N, Su-pawan V: A longitudinal study on dietary and social influences on riboflavin status in pre-school children in northeast Thailand. SE Asian J Trop Med Publ Hlth 1971; 2:552-563.