Brief report: Adult hippocampal precursor cells shorten S-phase and total cell cycle length during neuronal differentiation

Stem Cells

Volumn 30, Issue 12, 2012, Pages 2843-2847

  Brandt, Moritz D ^a,b,c   Hübner, Matthias ^a   Storch, Alexander ^a,b,c  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

Adult neurogenesis; Cell cycle kinetics; Chlorodeoxyuridine; Iododeoxyuridine; NeuroD1; S phase

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR SOX2;

ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL POPULATION; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; FEMALE; HIPPOCAMPAL PRECURSOR CELL; IN VIVO STUDY; MITOSIS; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; NEURONS; S PHASE;

EID: 84870381709     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1244     Document Type: Article

References (11)

1. Hayes NL, Nowakowski RS. Exploiting the dynamics of S-phase tracers in developing brain: Interkinetic nuclear migration for cells entering versus leaving the S-phase. Dev Neurosci 2000;22:44-55.
2. Dimitrova DS, Todorov IT, Melendy T et al. Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex. J Cell Biol 1999;146:709-722.
3. Vega CJ, Peterson DA. Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination. Nat Methods 2005;2:167-169.
4. Kempermann G, Gast D, Kronenberg G et al. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 2003;130:391-399.
5. Hayes NL, Nowakowski RS. Dynamics of cell proliferation in the adult dentate gyrus of two inbred strains of mice. Brain Res Dev Brain Res 2002;134:77-85.
6. Kronenberg G, Reuter K, Steiner B et al. Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli. J Comp Neurol 2003;467:455-463.
7. Kempermann G, Jessberger S, Steiner B et al. Milestones of neuronal development in the adult hippocampus. Trends Neurosci 2004;27: 447-452.
8. Gao Z, Ure K, Ables JL et al. Neurod1 is essential for the survival and maturation of adult-born neurons. Nat Neurosci 2009;12: 1090-1092.
9. Encinas JM, Michurina TV, Peunova N et al. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell 2011;8:566-579.
10. Arai Y, Pulvers JN, Haffner C et al. Neural stem and progenitor cells shorten S-phase on commitment to neuron production. Nat Commun 2011;2:154.
11. Brandt MD, Maass A, Kempermann G et al. Physical exercise increases Notch activity, proliferation and cell cycle exit of type-3 progenitor cells in adult hippocampal neurogenesis. Eur J Neurosci 2010;32:1256-1264.