Fatty acids in ADHD: Plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents

ADHD Attention Deficit and Hyperactivity Disorders

Volumn 4, Issue 4, 2012, Pages 199-204

  Johnson, Mats ^a   Månsson, Jan Eric ^a   Östlund, Sven ^a   Fransson, Gunnar ^a   Areskoug, Björn ^a   Hjalmarsson, Kerstin ^a   Landgren, Magnus ^b   Kadesjö, Björn ^a   Gillberg, Christopher ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Mariestad's Hospital   (Sweden)

Author keywords

Attention deficit hyperactivity disorder; Docosahexaenoic acid; Eicosapentaenoic acid; Essential fatty acids; Omega 3 6; Plasma fatty acids

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PHOSPHATIDYLCHOLINE; PLACEBO;

ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; CHILD HEALTH; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG RESPONSE; DSM-IV; FATTY ACID ANALYSIS; HUMAN; LIPID COMPOSITION; MAJOR CLINICAL STUDY; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; HUMANS; MALE; PHOSPHATIDYLCHOLINES; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; TIME FACTORS;

EID: 84870369770     PISSN: 18666116     EISSN: 18666647     Source Type: Journal    
DOI: 10.1007/s12402-012-0084-4     Document Type: Article

References (14)

1. Chen JR, Hsu SF, Hsu CD et al (2004) Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. J Nutr Biochem 15: 467-472.
2. DuPaul GJ, Power TJ, Anastopoulos AD, Reid R (1998) ADHD rating scale-IV: checklists, norms, and clinical interpretations. Guilford, New York.
3. Germano M, Meleleo D, Monorfano G, Adorni L, Negroni M, Berra B et al (2007) Plasma, red blood cell phospholipids and clinical evaluation after long chain omega-3 supplementation in children with attention deficit hyperactivity disorder (ADHD). Nutr Neurosci 10: 1-9.
4. Gustafsson P, Birberg-Thornberg U, Duchén K, Landgren M, Malmberg K, Pelling H et al (2010) EPA supplementation improves teacher-rated behaviour and oppositional symptoms in children with ADHD. Acta Paediatr 99: 1540-1549.
5. Guy W (1976) ECDEU Assessment manual for psychopharmacology. Revised. Bethesda (MD), US Department of health, education, and welfare.
6. Haag M (2003) Essential fatty acids and the brain. Can J Psychiatry 48: 195-203.
7. Innis SM (2007) Dietary (n-3) fatty acids and brain development. J Nutr 137: 855-859.
8. Johnson M, Östlund S, Fransson G, Kadesjö B, Gillberg C (2009) Omega-3/Omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J Att Disorders 12: 394-401.
9. Landen M, Davidsson P, Gottfries C-G et al (2002) Reduction of the synaptophysin level but normal levels of glycerophospholipids in the gyrus cinguli in schizofrenia. Schizophrenia Res 55: 83-88.
10. Percy P, Vilbergsson G, Percy A et al (1991) The fatty acid composition of placenta in intrauterine growth retardation. Biochim Biophys Acta 1084: 173-177.
11. Richardson AJ, Montgomery P (2005) The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 115: 1360-1366.
12. Richardson AJ, Puri BK (2002) A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuro-Psychopharmacol Biol Psychiatry 26: 233-239.
13. Sinn N, Bryan J (2007) Effect of supplementation with polyunsaturated fatty acids and micronutrients on ADHD-related problems with attention and behaviour. J Dev Behav Pediatr 28: 82-91.
14. Stevens LJ, Zentall SS, Deck JL, Abate ML, Watkins BA, Lipp SR et al (1995) Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 62: 761-768.