Exploring molecular links between lymph node invasion and cancer prognosis in human breast cancer

BMC Systems Biology

Volumn 5, Issue SUPPL2, 2011, Pages

  Kim, Sangwoo ^a,b   Nam, Hojung ^c   Lee, Doheon ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST TUMOR; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE; GENETICS; HUMAN; LYMPH NODE; LYMPH NODE METASTASIS; META ANALYSIS; PATHOLOGY; PROGNOSIS; REGRESSION ANALYSIS;

BREAST NEOPLASMS; DATABASES, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; PROGNOSIS; REGRESSION ANALYSIS;

EID: 84870367428     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-5-S2-S4     Document Type: Article

References (50)

1. McGuire WL. Prognostic factors for recurrence and survival in human breast cancer. Breast Cancer Research and Treatment 1987, 10:5-9. 10.1007/BF01806129, 3689982.
2. Foster RS. The biologic and clinical significance of lymphatic metastases in breast cancer. Surgical oncology clinics of North America 1996, 5:79.
3. Christine LC, Carol A, Donald EH. Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases. Cancer 1989, 63:181-187. 10.1002/1097-0142(19890101)63:1<181::AID-CNCR2820630129>3.0.CO;2-H, 2910416.
4. Fidler IJ. THE PATHOGENESIS OF CANCER METASTASIS: THE 'SEED AND SOIL' HYPOTHESIS REVISITED. Nature Reviews Cancer 2003, 3:453-458. 10.1038/nrc1098, 12778135.
5. Gupta GP, Massague J. Cancer Metastasis: Building a Framework. Cell 2006, 127:679-695. 10.1016/j.cell.2006.11.001, 17110329.
6. Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007, 8:341-352.
7. Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K. Metastasis: Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2002, 2:573-583. 10.1038/nrc863, 12154350.
8. Jatoi I, Hilsenbeck SG, Clark GM, Osborne CK. Significance of Axillary Lymph Node Metastasis in Primary Breast Cancer. J Clin Oncol 1999, 17:2334-2340.
9. Nasser IA, Lee AK, Bosari S, Saganich R, Heatley G, Silverman ML. Occult axillary lymph node metastases in node-negative breast carcinoma. Human pathology 1993, 24:950. 10.1016/0046-8177(93)90108-S, 7504652.
10. Gasparini G, Weidner N, Bevilacqua P, Maluta S, Dalla Palma P, Caffo O, Barbareschi M, Boracchi P, Marubini E, Pozza F. Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node- negative breast carcinoma. J Clin Oncol 1994, 12:454-466.
11. Sorlie T. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98:10869-10874. 10.1073/pnas.191367098, 58566, 11553815.
12. van de Vijver MJ. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002, 347:1999-2009. 10.1056/NEJMoa021967, 12490681.
13. van't Veer LJ. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002, 415:530-536. 10.1038/415530a, 11823860.
14. Ramaswamy S, Ross KN, Lander ES, Golub TR. A molecular signature of metastasis in primary solid tumors. Nature Genet 2003, 33:49-54. 10.1038/ng1060, 12469122.
15. Wang Y, Klijn JGM, Zhang Y, Sieuwerts AM, Look MP, Yang F, Talantov D, Timmermans M, Meijer-van Gelder ME, Yu J, et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. The Lancet 2005, 365:671-679.
16. Sun Y, Goodison S, Li J, Liu L, Farmerie W. Improved breast cancer prognosis through the combination of clinical and genetic markers. Bioinformatics 2007, 23:30-37. 10.1093/bioinformatics/btl543, 17130137.
17. Suzuki M, Tarin D. Gene expression profiling of human lymph node metastases and matched primary breast carcinomas: clinical implications. Molecular oncology 2007, 1:172-180. 10.1016/j.molonc.2007.03.005, 19383293.
18. Abba MC, Sun H, Hawkins KA, Drake JA, Hu Y, Nunez MI, Gaddis S, Shi T, Horvath S, Sahin A. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Molecular Cancer Research 2007, 5:881. 10.1158/1541-7786.MCR-07-0055, 17855657.
19. Ellsworth RE, Seebach J, Field LA, Heckman C, Kane J, Hooke JA, Love B, Shriver CD. A gene expression signature that defines breast cancer metastases. Clinical and Experimental Metastasis 2009, 26:205-213. 10.1007/s10585-008-9232-9, 19112599.
20. Singletary SE, Connolly JL. Breast Cancer Staging: Working With the Sixth Edition of the AJCC Cancer Staging Manual. CA Cancer J Clin 2006, 56:37-47. 10.3322/canjclin.56.1.37, 16449185.
21. Weigelt B, Wessels LFA, Bosma AJ, Glas AM, Nuyten DSA, He YD, Dai H, Peterse JL, van't Veer LJ. No common denominator for breast cancer lymph node metastasis. Br J Cancer 2005, 93:924-932. 10.1038/sj.bjc.6602794, 2361648, 16189523.
22. Dickey DA, Fuller WA. Distribution of the estimators for autoregressive time series with a unit root. Journal of the American statistical association 1979, 427-431.
23. W MC. Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach. Journal of Evolutionary Biology 2005, 18:1368-1373. 10.1111/j.1420-9101.2005.00917.x, 16135132.
24. Eden E, Navon R, Steinfeld I, Lipson D, Yakhini Z. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 2009, 10:48. 10.1186/1471-2105-10-48, 2644678, 19192299.
25. Noriaki S, Hiroyuki K, Masayuki W, Soichiro M, Masaki M, Keizo S. Local immune response to tumor invasion in esophageal squamous cell carcinoma: The expression of human leukocyte antigen-DR and lymphocyte infiltration. Cancer 1994, 74:586-591. 10.1002/1097-0142(19940715)74:2<586::AID-CNCR2820740209>3.0.CO;2-4, 8033037.
26. de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 2006, 6:24-37. 10.1038/nrc1782, 16397525.
27. Byrne KJO, Dalgleish AG, Browning MJ, Steward WP, Harris AL. The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. European journal of cancer (Oxford, England : 1990) 2000, 36:151-169.
28. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:15545-15550. 10.1073/pnas.0506580102, 1239896, 16199517.
29. Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005, 5:263-274. 10.1038/nrc1586, 15776005.
30. Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL. Association of Macrophage Infiltration with Angiogenesis and Prognosis in Invasive Breast Carcinoma. Cancer Res 1996, 56:4625-4629.
31. Lin EY, Pollard JW. Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer. Cancer Res 2007, 67:5064-5066. 10.1158/0008-5472.CAN-07-0912, 17545580.
32. Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004, 4:71-78. 10.1038/nrc1256, 14708027.
33. DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM. CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages. Cancer Cell 2009, 16:91-102. 10.1016/j.ccr.2009.06.018, 2778576, 19647220.
34. Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi J-T, Rijn M, Botstein D, Brown PO. Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds. PLoS Biol 2004, 2:e7. 10.1371/journal.pbio.0020007, 314300, 14737219.
35. Zambelli F, Pesole G, Pavesi G. Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes. Nucl Acids Res 2009, 37:W247-252. 10.1093/nar/gkp464, 2703934, 19487240.
36. Dennis G, Sherman B, Hosack D, Yang J, Gao W, Lane HC, Lempicki R. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biology 2003, 4:P3. 10.1186/gb-2003-4-5-p3, 12734009.
37. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protocols 2008, 4:44-57.
38. Vlieghe D, Sandelin A, De Bleser PJ, Vleminckx K, Wasserman WW, van Roy F, Lenhard B. A new generation of JASPAR, the open-access repository for transcription factor binding site profiles. Nucl Acids Res 2006, 34:D95-97. 10.1093/nar/gkj115, 1347477, 16381983.
39. Dalton S, Treisman R. Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 1992, 68:597-612. 10.1016/0092-8674(92)90194-H, 1339307.
40. Wang Y, Liu D-P, Chen P-P, Koeffler HP, Tong X-J, Xie D. Involvement of IFN Regulatory Factor (IRF)-1 and IRF-2 in the Formation and Progression of Human Esophageal Cancers. Cancer Res 2007, 67:2535-2543. 10.1158/0008-5472.CAN-06-3530, 17363571.
41. Huang S, B CD, Van Arsdall M, Fidler IJ. Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells. Oncogene 2002, 21:2504-2512. 10.1038/sj.onc.1205341, 11971185.
42. Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, et al. STAT1 Pathway Mediates Amplification of Metastatic Potential and Resistance to Therapy. PLoS ONE 2009, 4:e5821. 10.1371/journal.pone.0005821, 2688034, 19503789.
43. Woelfle U, Assmann V, Pantel K. Conditionally active STAT1 and its functional role in tumor progression and invasion. AACR Meeting Abstracts 2006, 2006:430-a-
44. Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009, 9:798-809. 10.1038/nrc2734, 19851315.
45. Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006, 9:121-132. 10.1016/j.ccr.2006.01.013, 16473279.
46. Wilson CL, Miller CJ. Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis. Bioinformatics 2005, 21:3683-3685. 10.1093/bioinformatics/bti605, 16076888.
47. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004, 6:1-6. 1635162, 15068665.
48. Fisher RA. Statistical methods for research workers Edinburgh. Oliver and Boyd 1950, 354.
49. Stouffer SA, DeVinney LC, Suchmen EA. The American soldier: Adjustment during army life. 1949, Princeton University Press Princeton, NJ.
50. Hong F, Breitling R. A comparison of meta-analysis methods for detecting differentially expressed genes in microarray experiments. Bioinformatics 2008, 24:374-382. 10.1093/bioinformatics/btm620, 18204063.