A dramatic response to crizotinib in a non-small-cell lung cancer patient with IHC-positive and FISH-negative ALK

Journal of Thoracic Oncology

Volumn 7, Issue 12, 2012, Pages

  Sun, Jong Mu ^a   Choi, Yoon La ^a   Won, Jae Kyung ^b   Hirsch, Fred R ^c   Ahn, Jin Seok ^a   Ahn, Myung Ju ^a   Park, Keunchil ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Seoul National University Cancer Hospital   (South Korea)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CISPLATIN; CRIZOTINIB; GEMCITABINE;

ADULT; ADVANCED CANCER; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; HEMATOTHORAX; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MEDIASTINUM LYMPH NODE; OUTCOME ASSESSMENT; PLEURA EFFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THORAX RADIOGRAPHY; TREATMENT RESPONSE;

EID: 84870318934     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e318274694e     Document Type: Article

References (5)

1. Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-1703.
2. Crino L, Kim D, Riely GJ, et al. Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005. ASCO Meeting Abstracts 2011;29:7514.
3. Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010;16:1561-1571.
4. McLeer-Florin A, Moro-Sibilot D, Melis A, et al. Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study. J Thorac Oncol 2012;7:348-354.
5. Paik JH, Choe G, Kim H, et al. Screening of anaplastic lymphoma kinase rearrangement by immunohistochemistry in non-small cell lung cancer: correlation with fluorescence in situ hybridization. J Thorac Oncol 2011;6:466-472.