Correlations between the levels of Oct4 and Nanog as a signature for naïve pluripotency in mouse embryonic stem cells

Stem Cells

Volumn 30, Issue 12, 2012, Pages 2683-2691

  Descalzo, Silvia Muñoz ^a   Rué, Pau ^b   Garcia Ojalvo, Jordi ^b   Arias, Alfonso Martinez ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

Embryonic stem cells; Pluripotent stem cells; Self renewal; Serum free; Transcription factors

Indexed keywords

MUTANT PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG;

ANIMAL CELL; ARTICLE; BETA CATENIN GENE; CELL DIFFERENTIATION; CELL LINEAGE; CELL SUBPOPULATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; GENE; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; QUANTITATIVE ANALYSIS; TCF3 GENE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HOMEODOMAIN PROTEINS; MICE; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; SIGNAL TRANSDUCTION;

EID: 84870312110     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1230     Document Type: Article

References (30)

1. Smith AG. Embryo-derived stem cells: Of mice and men. Annu Rev Cell Dev Biol 2001;17:435-462.
2. Young RA. Control of the embryonic stem cell state. Cell 2011;144:940-954.
3. Silva J, Smith A. Capturing pluripotency. Cell 2008;132:532-536.
4. Yi F, Pereira L, Hoffman JA et al. Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal. Nat Cell Biol 2011;13:762-770.
5. Yi F, Pereira L, Merrill BJ. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Stem Cells 2008;26:1951-1960.
6. Wray J, Kalkan T, Gomez-Lopez S et al. Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation. Nat Cell Biol 2011;13:838-845.
7. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
8. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-317.
9. Silva J, Barrandon O, Nichols J et al. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 2008;6: e253.
10. Marson A, Foreman R, Chevalier B et al. Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 2008;3:132-135.
11. Ying QL, Wray J, Nichols J et al. The ground state of embryonic stem cell self-renewal. Nature 2008;453:519-523.
12. Martinez Arias A, Brickman JM. Gene expression heterogeneities in embryonic stem cell populations: Origin and function. Curr Opin Cell Biol 2011;23:650-656.
13. Wray J, Kalkan T, Smith AG. The ground state of pluripotency. Biochem Soc Trans 2010;38:1027-1032.
14. Silva J, Chambers I, Pollard S et al. Nanog promotes transfer of pluripotency after cell fusion. Nature 2006;441:997-1001.
15. Theunissen TW, van Oosten AL, Castelo-Branco G et al. Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol 2011;21:65-71.
16. Lyashenko N, Winter M, Migliorini D et al. Differential requirement for the dual functions of beta-catenin in embryonic stem cell self-renewal and germ layer formation. Nat Cell Biol 2011;13:753-761.
17. Chambers I, Silva J, Colby D et al. Nanog safeguards pluripotency and mediates germline development. Nature 2007;450:1230-1234.
18. Pereira L, Yi F, Merrill BJ. Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol 2006;26:7479-7491.
19. Kalmar T, Lim C, Hayward P et al. Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol 2009;7:e1000149.
20. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000;24:372-376.
21. Guo G, Huang Y, Humphreys P et al. A PiggyBac-based recessive screening method to identify pluripotency regulators. PLoS One 2011;6:e18189.
22. Thomson M, Liu SJ, Zou LN et al. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 2011;145:875-889.
23. Welham MJ, Kingham E, Sanchez-Ripoll Y et al. Controlling embryonic stem cell proliferation and pluripotency: The role of PI3K- and GSK-3-dependent signalling. Biochem Soc Trans 2011;39:674-678.
24. Yi F, Merrill BJ. Stem cells and TCF proteins: A role for beta-catenin- independent functions. Stem Cell Rev 2007;3:39-48.
25. Loh YH, Wu Q, Chew JL et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 2006;38:431-440.
26. Chambers I. The molecular basis of pluripotency in mouse embryonic stem cells. Cloning Stem Cells 2004;6:386-391.
27. Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci USA 2008;105:6326-6331.
28. Carey BW, Markoulaki S, Hanna JH et al. Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell 2011;9:588-598.
29. Miyanari Y, Torres-Padilla ME. Control of ground-state pluripotency by allelic regulation of Nanog. Nature 2012;483:470-473.
30. Canham MA, Sharov AA, Ko MS et al. Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol 2010;8:e1000379.