Parental Diabetes: The Akita Mouse as a Model of the Effects of Maternal and Paternal Hyperglycemia in Wildtype Offspring

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Grasemann, Corinna ^a,b   Devlin, Maureen J ^c   Rzeczkowska, Paulina A ^b   Herrmann, Ralf ^a   Horsthemke, Bernhard ^a   Hauffa, Berthold P ^a   Grynpas, Marc ^d   Alm, Christina ^b   Bouxsein, Mary L ^c   Palmert, Mark R ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY FAT; BODY WEIGHT; BONE DENSITY; BONE MASS; CONTROLLED STUDY; DIABETES MELLITUS; FATHER; GLUCOSE TOLERANCE TEST; HETEROZYGOSITY; HYPERGLYCEMIA; HYPOINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; LEAN BODY WEIGHT; LIPID DIET; MOTHER; MOUSE; NONHUMAN; PARENTAL DIABETES MELLITUS; PHENOTYPE; PHENOTYPIC VARIATION; PROGENY; SEX DIFFERENCE; TRABECULAR BONE; WEIGHT REDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; BONE AND BONES; DISEASE MODELS, ANIMAL; FEMALE; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HETEROZYGOTE; HYPERGLYCEMIA; INSULIN; MALE; MICE; MICE, INBRED C57BL; PHENOTYPE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEX CHARACTERISTICS;

MUS;

EID: 84870307307     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050210     Document Type: Article

References (29)

1. Hales CN, Barker DJ, (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35: 595-601.
2. Boney CM, Verma A, Tucker R, Vohr BR, (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115: e290-e296.
3. Van Assche FA, Holemans K, Aerts L, (2001) Long-term consequences for offspring of diabetes during pregnancy. Br Med Bull 60: 173-182.
4. Bush NC, Chandler-Laney PC, Rouse DJ, Granger WM, Oster RA, et al. (2011) Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function. J Clin Endocrinol Metab 96: E803-E809.
5. Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE, (2003) Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res 53: 411-418.
6. Gauguier D, Bihoreau MT, Ktorza A, Berthault MF, Picon L, (1990) Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats. Diabetes 39: 734-739.
7. Harder T, Rake A, Rohde W, Doerner G, Plagemann A, (1999) Overweight and increased diabetes susceptibility in neonatally insulin-treated adult rats. Endocr Regul 33: 25-31.
8. Gauguier D, Bihoreau MT, Picon L, Ktorza A, (1991) Insulin secretion in adult rats after intrauterine exposure to mild hyperglycemia during late gestation. Diabetes 40 Suppl 2: 109-114.
9. Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, et al. (2010) Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143: 1084-1096.
10. Kayo T, Koizumi A, (1998) Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period. J Clin Invest 101: 2112-2118.
11. Matthews JN, Altman DG, Campbell MJ, Royston P, (1990) Analysis of serial measurements in medical research. BMJ 300: 230-235.
12. Bouxsein ML, Pierroz DD, Glatt V, Goddard DS, Cavat F, et al. (2005) beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J Bone Miner Res 20: 635-643.
13. Glatt V, Canalis E, Stadmeyer L, Bouxsein ML, (2007) Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res 22: 1197-1207.
14. Selker F, Carter DR, (1989) Scaling of long bone fracture strength with animal mass. J Biomech 22: 1175-1183.
15. Strakovsky RS, Zhang X, Zhou D, Pan YX, (2011) Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats. J Physiol 589: 2707-2717.
16. Dunn GA, Bale TL, (2011) Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology 152: 2228-2236.
17. Samuelsson AM, Matthews PA, Argenton M, Christie MR, McConnell JM, et al. (2008) Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension 51: 383-392.
18. Koukkou E, Ghosh P, Lowy C, Poston L, (1998) Offspring of normal and diabetic rats fed saturated fat in pregnancy demonstrate vascular dysfunction. Circulation 98: 2899-2904.
19. Lau SM, Lin S, Stokes RA, Cheng K, Baldock PA, et al. (2011) Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice. Diabetologia 54: 910-921.
20. Huyen J-PDV, Vessières E, Perret C, Troise A, Prince S, et al. (2010) In Utero Exposure to Maternal Diabetes Impairs Vascular Expression of Prostacyclin Receptor in Rat Offspring. Diabetes 59: 2597.
21. Bond H, Sibley CP, Balment RJ, Ashton N, (2005) Increased renal tubular reabsorption of calcium and magnesium by the offspring of diabetic rat pregnancy. Pediatr Res 57: 890-895.
22. Plagemann A, Harder T, Brunn M, Harder A, Roepke K, et al. (2009) Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol 587: 4963-4976.
23. Simmons RA, (2007) Developmental origins of diabetes: the role of epigenetic mechanisms. Curr Opin Endocrinol Diabetes Obes 14: 13-16.
24. Yoshioka M, Kayo T, Ikeda T, Koizumi A, (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46: 887-894.
25. Lanham SA, Roberts C, Hollingworth T, Sreekumar R, Elahi MM, et al. (2010) Maternal high-fat diet: effects on offspring bone structure. Osteoporos Int 21: 1703-1714.
26. Karsenty G, Oury F, (2010) The central regulation of bone mass, the first link between bone remodeling and energy metabolism. J Clin Endocrinol Metab 95: 4795-4801.
27. Nüsken KD, Schneider H, Plank C, Trollmann R, Nüsken E, et al. (2011) Fetal programming of gene expression in growth-restricted rats depends on the cause of low birth weight. Endocrinology 152: 1327-1335.
28. Zambrano E, Martínez-Samayoa PM, Bautista CJ, Deás M, Guillén L, et al. (2005) Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. J Physiol 566: 225-236.
29. Riant E, Waget A, Cogo H, Arnal JF, Burcelin R, et al. (2009) Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology 150: 2109-2117.