Invited editorial commentary for American Heart Journal mechanisms of exercise training in heart failure with preserved ejection fraction: Central disappointment and peripheral promise

American Heart Journal

Volumn 164, Issue 6, 2012, Pages 807-809

  Kitzman, Dalane W ^a   Haykowsky, Mark J ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHLORIDE;

BLOOD GAS ANALYSIS; EXERCISE; EXERCISE TOLERANCE; HEART CATHETERIZATION; HEART FAILURE; HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION; HEART FUNCTION; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEART TRANSPLANTATION; HEMODYNAMIC PARAMETERS; HUMAN; MEDICAL INFORMATION; MUSCLE METABOLISM; NOTE; OUTCOME ASSESSMENT; OXYGEN TRANSPORT; PATHOPHYSIOLOGY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SKELETAL MUSCLE; TREATMENT OUTCOME;

EID: 84870301016     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2012.09.002     Document Type: Editorial

References (24)

1. D.W. Kitzman, J.M. Gardin, and J.S. Gottdiener Importance of heart failure with preserved systolic function in patients > or = 65 years of age. CHS Research Group. Cardiovascular Health Study Am J Cardiol 87 2001 413 419
2. T.E. Owan, D.O. Hodge, and R.M. Herges Trends in prevalence and outcome of heart failure with preserved ejection fraction N Engl J Med 355 2006 251 259
3. D.W. Kitzman, M.B. Higginbotham, and F.R. Cobb Exercise intolerance in patients with heart failure and preserved left ventricular systolic function: failure of the Frank-Starling mechanism J Am Coll Cardiol 17 1991 1065 1072
4. D.W. Kitzman, W.C. Little, and P.H. Brubaker Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure JAMA 288 2002 2144 2150
5. M.J. Haykowsky, P.H. Brubaker, and J.M. John Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction J Am Coll Cardiol 58 2011 265 274
6. B.A. Borlaug, V. Melenovsky, and S.D. Russell Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction Circulation 114 2006 2138 2147
7. P.S. Bhella, A. Prasad, and K. Heinicke Abnormal haemodynamic response to exercise in heart failure with preserved ejection fraction Eur J Heart Fail 13 2011 1296 1304
8. M.T. Maeder, B.R. Thompson, and H.-P. Brunner-La Rocca Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction J Am Coll Cardiol 56 2010 855 863
9. S. Yusuf, M.A. Pfeffer, and K. Swedberg Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial Lancet 362 2003 777 781
10. B.M. Massie, P.E. Carson, and J.J. McMurray Irbesartan in patients with heart failure and preserved ejection fraction N Engl J Med 359 2008 2456 2467
11. R.S. Taylor, E.J. Davies, and H.M. Dalal Effects of exercise training for heart failure with preserved ejection fraction: a systematic review and meta-analysis of comparative studies Int J Cardiol 2012 10.1016/j.ijcard.2012. 05.070 [Epub ahead of print]
12. F. Edelmann, G. Gelbrich, and H.D. Doingen Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study J Am Coll Cardiol 58 2011 1780 1791
13. D.W. Kitzman, P.H. Brubaker, and T.M. Morgan Exercise training in older patients with heart failure and preserved ejection fraction Circ Heart Fail 3 2010 659 667
14. N. Fujimoto, A. Prasad, and J.L. Hastings Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction Am Heart J 164 2012 869 877
15. M.J. Haykowsky, P.H. Brubaker, and K.P. Stewart Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction J Am Coll Cardiol 60 2012 120 128
16. J.R. Minotti, E.C. Johnson, and T.L. Hudson Skeletal muscle response to exercise training in congestive heart failure J Clin Invest 86 1990 751 758
17. D. Harrington, S.D. Anker, and T.P. Chua Skeletal muscle function and its relation to exercise tolerance in chronic heart failure J Am Coll Cardiol 30 1997 1758 1764
18. A.L. Clark, and P.A. Poole-Wilson Exercise limitation in chronic heart failure: central role of the periphery J Am Coll Cardiol 28 1996 1092 1102
19. M. Sullivan, J.D. Knight, and M.B. Higginbotham Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure: muscle blood flow is reduced with maintenance of arterial perfusion pressure Circulation 80 1989 769 781
20. M.J. Sullivan, H.J. Green, and F.R. Cobb Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart failure Circulation 81 1990 518 527
21. M. Sullivan, M.B. Higginbotham, and F.R. Cobb Exercise training in patients with chronic heart failure delays ventilatory anaerobic threshold and improves submaximal exercise performance Circulation 79 1989 324 329
22. A. Coats Exercise training for heart failure: coming of age Circulation 99 1999 1138 1140
23. P.A. Beere, S.D. Russell, and M.C. Morey Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men Circulation 100 1999 1085 1094
24. P. Kortebein, T.B. Symons, and A. Ferrando Functional impact of 10 days of bed rest in healthy older adults J Gerontol A Biol Sci Med Sci 63 2008 1076 1081