Elevated serum osteopontin level is associated with blood eosinophilia and asthma comorbidity in patients with allergic rhinitis

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 6, 2012, Pages 1416-1418.e6

  Liu, Wenlong ^a   Xia, Wentong ^b   Fan, Yunping ^b   Wang, Hongtian ^c   Zuo, Kejun ^a   Lai, Yinyan ^a   Li, Huabin ^a   Liu, Zheng ^d   Shi, Jianbo ^a   Xu, Geng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIFTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALLERGEN; EOSINOPHIL CATIONIC PROTEIN; INTERLEUKIN 5; MONOCLONAL ANTIBODY; OSTEOPONTIN; OSTEOPONTIN ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

AIRWAY; ALLERGIC RHINITIS; ASTHMA; BLOOD SAMPLING; BRONCHUS MUCOSA; CELL ISOLATION; CELL MIGRATION; COMORBIDITY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG EFFICACY; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; EOSINOPHILIA; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LABORATORY TEST; LETTER; MACROPHAGE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RISK FACTOR; SERUM; SIGNAL TRANSDUCTION; TH2 CELL;

EID: 84870291104     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.06.010     Document Type: Article

References (9)

1. J. Bousquet, N. Khaltaev, A.A. Cruz, J. Denburg, W.J. Fokkens, and A. Togias Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen) Allergy 63 2008 8 160
2. S. Konno, M. Kurokawa, T. Uede, M. Nishimura, and S.K. Huang Role of osteopontin, a multifunctional protein, in allergy and asthma Clin Exp Allergy 41 2011 1360 1366
3. I. Puxeddu, N. Berkman, D. Ribatti, R. Bader, H.M. Haitchi, and D.E. Davies Osteopontin is expressed and functional in human eosinophils Allergy 65 2010 168 174
4. K. Samitas, E. Zervas, S. Vittorakis, M. Semitekolou, T. Alissafi, and A. Bossios Osteopontin expression and relation to disease severity in human asthma Eur Respir J 37 2011 331 341
5. G. Xu, J. Shi, and H. Li Regulation of osteopontin expression in human airway epithelial cells Allergy 65 2010 8
6. Y. Fan, W. Xia, W. Liu, R. Chen, X. Li, and R. Xu Increased nasal IL-5 levels act as a predisposing factor of asthma in southern China J Allergy Clin Immunol 127 2011 1312 1313
7. A. Klein Jan, M. Willart, M. van Nimwegen, K. Leman, H.C. Hoogsteden, and R.W. Hendriks United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation Clin Exp Allergy 40 2010 494 504
8. G. Xanthou, T. Alissafi, M. Semitekolou, D.C. Simoes, E. Economidou, and M. Gaga Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets Nat Med 13 2007 570 578
9. D.C. Simoes, G. Xanthou, K. Petrochilou, V. Panoutsakopoulou, C. Roussos, and C. Gratziou Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma Am J Respir Crit Care Med 179 2009 894 902