Associations between health-related self-protection, diurnal cortisol, and C-reactive protein in lonely older adults

Psychosomatic Medicine

Volumn 74, Issue 9, 2012, Pages 937-944

  Rueggeberg, Rebecca ^a   Wrosch, Carsten ^a   Miller, Gregory E ^b   McDade, Thomas W ^c  

^a Dept of Electrical and Computer Engineering   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Aging; C reactive protein; diurnal cortisol; loneliness; self protection

Indexed keywords

C REACTIVE PROTEIN; HYDROCORTISONE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; FEMALE; FOLLOW UP; HEALTH; HUMAN; HYDROCORTISONE RELEASE; LONELINESS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTECTION; SELF PROTECTION;

EID: 84870253678     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e3182732dc6     Document Type: Article

References (59)

1. Cacioppo JT, Hawkley LC, Crawford, LE, Ernst JM, Burleson MH, Kowalewski RB, Malarkey WB, Van Cauter E, Berntson GG. Loneliness and health: potential mechanisms. Psychosom Med 2002;64:407-17.
2. Heinrich LM, Gullone E. The clinical significance of loneliness: a literature review. Clin Psychol Rev 2006;26:695-718.
3. Hawkley LC, Cacioppo JT. Aging and loneliness: downhill quickly? Curr Dir Psychol Sci 2007;16:187-91.
4. Baltes PB, Cornelius SW, Nesselroade JR. Cohort effects in developmental psychology. In: Nesselroade JR, Baltes PB, editors. Longitudinal Research in the Study of Behavior and Development. New York: Academic Press; 1979:61-87.
5. Heckhausen J, Wrosch C, Schulz R. A motivational theory of life-span development. Psychol Rev 2010;117:32-60.
6. Wrosch C, Miller GE, Schulz R. Cortisol secretion and functional disabilities in old age: importance of using adaptive control strategies. Psychosom Med 2009;71:996-1003.
7. Kiecolt-Glaser JK, Ricker D, George J, Messick G, Speicher CE, Garner W, Glaser R. Urinary cortisol levels, cellular immunocompetency, and loneliness in psychiatric inpatients. Psychosom Med 1984;46:15-23.
8. Russell DW, Cutrona CE, De La Mora A, Wallace RB. Loneliness and nursing home admission among rural older adults. Psychol Aging 1997;12: 574-89.
9. Seeman TE. Health promoting effects of friends and family on health outcomes in older adults. Am J Health Promot 2000;14:362-70.
10. Sugisawa H, Liang J, Liu X. Social networks, social support, and mortality among older people in Japan. J Gerontol 1994;49:3-13.
11. Hawkley LC, Cacioppo JT. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann Behav Med 2010;40: 218-27.
12. Cacioppo JT, Hawkley LC, Rickett EM, Masi CM. Sociality, spirituality, and meaning making: Chicago health, aging, and social relations study. Rev Gen Psychol 2005;9:143-55.
13. Cacioppo JT, Ernst JM, Burleson MH, McClintock MK, Malarkey WB, Hawkley LC, Kowalewski RB, Paulsen A, Hobson JA, Hugdahl K, Spiegel D, Berntson GG. Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies. Int J Psychophysiol 2000;35: 143-54.
14. Steptoe A, Owen N, Kunz-Ebrecht SR, Brydon L. Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middleaged men and women. Psychoneuroendocrinology 2004;29:593-611.
15. Cacioppo JT, Hawkley LC, Berntson G. Do lonely days invade the nights? Potential social modulation of sleep efficiency. Psychol Sci 2002;13: 384-7.
16. Mahon NE, Yarcheski A, Yarcheski TJ. Mental health variables and positive health practices in early adolescents. Psychol Rep 2001;88:1023-30.
17. McDade TW, Hawkley LC, Cacioppo JT. Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study. Psychosom Med 2006;68:376-81.
18. Cole SW, Hawkley LC, Arevalo JM, Sung CY, Rose RM, Cacioppo JT. Social regulation of gene expression in human leukocytes. Genome Biol 2007;8:R189.
19. Ridker PM, Rifai N, Rose L, Buring JE, Cook NR. Comparison of Creactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347:1557-65.
20. Kuo H-K, Bean JF, Yen C-J, Leveille SG. Linking C-reactive protein to late-life disability in the National Health and Nutrition Examination Survey (NHANES) 1999-2002. J Gerontol A Biol Sci Med Sci 2006;61:380-7.
21. Jenny NS, Yanez ND, Psaty BM, Kuller LH, Hirsch CH, Tracy RP. Inflammation biomarkers and near-term death in older men. Am J Epidemiol 2007;165:684-95.
22. Ridker PM, Silvertown JD. Inflammation, C-reactive protein, and atherothrombosis. J Periodontol 2008;79:1544-51.
23. Strandberg T. C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arteriosclerosis 2000;20:1057-60.
24. Wrosch C, Schulz R. Health stresses and depressive symptomatology in the elderly. Curr Dir Psychol Sci 2004;13:17-20.
25. Löckenhoff CE, Carstensen LL. Socioemotional selectivity theory, aging, and health: the increasingly delicate balance between regulating emotions and making tough choices. J Pers 2004;72:1393-424.
26. Watkins A. Mind-Body Medicine: A Clinician's Guide to Psychoneuroimmunology. London: Churchill Livingstone; 1997.
27. Doane LD, Adam EK. Loneliness and cortisol: momentary, day-to-day, and trait associations. Psychoneuroendocrinology 2010;35:430-41.
28. Hawkley L, Masi C, Berry J. Loneliness is a unique predictor of age-related differences in systolic blood pressure. Psychol Aging 2006;21:152-64.
29. Wrosch C, Heckhausen J. Primary and secondary control strategies for managing health and financial stress across adulthood. Psychol Aging 2000;15:387-99.
30. Wrosch C, Dunne E, Scheier MF, Schulz R. Self-regulation of common age-related challenges: benefits for older adults' psychological and physical health. J Behav Med 2006;29:299-306.
31. Heckhausen J, Schulz R. A life-span theory of control. Psychol Rev 1995; 102:284-304.
32. Wheaton B. Models for the stress-buffering functions of coping resources. J Health Soc Behav 1985;26:352-64.
33. Wrosch C, Schulz R, Miller GE, Lupien S, Dunne E. Physical health problems, depressive mood, and cortisol secretion in old age: buffer effects of health engagement control strategies. Health Psychol 2007;26:341-9.
34. Wrosch C, Heckhausen J. Perceived control of life regrets: good for young and bad for old adults. Psychol Aging 2002;17:340-50.
35. Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol 2005;24:297-306.
36. Prince MJ, Harwood RH, Blizard RA, Thomas A, Mann AH. Social support deficits, loneliness and life events as risk factors for depression in old age. The Gospel Oak Project VI. Psychol Med 1997;27:323-32.
37. Pinquart M. Influences on loneliness in older adults: a meta-analysis. Basic Appl Soc Psychol 2001;23:245-66.
38. Sarason IG, Levine HM, Basham RB, Sarason BR. Assessing social support: the social support questionnaire. J Pers Soc Psychol 1981;44:127-39.
39. Clements AD, Parker CR. The relationship between salivary cortisol concentrations in frozen versus mailed samples. Psychoneuroendocrinology 1998;23:613-6.
40. Dressendörfer RA, Kirschbaum C, Rohde W, Stahl F, Strasburger CJ. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J Steroid Biochem Mol Biol 1992;43:683-92.
41. McDade T, Burhop J. High-sensitivity enzyme immunoassay for C-reactive protein in dried blood spots. Clin Chem 2004;50:652-4.
42. Williams SR, McDade TW. The use of dried blood spot sampling in the national social life, health, and aging project. J Gerontol B Psychol Sci Soc Sci 2009;64:131-6.
43. Adler NE, Epel ES, Castellazzo G, Ickovics JR. Relationship of subjective and Objective social status with psychological and physiological functioning: preliminary data in healthy, white women. Health Psychol 2000; 19:586-92.
44. Preacher KJ, Hayes AF. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 2008;40:879-91.
45. Aging NACO. Seniors in Canada: 2006 Report Card. Ottawa, Canada: National Advisory Committee; 2006.
46. Aiken L, West S. Multiple Regression: Testing and Interpreting Interactions. Newbury Park, CA. Sage Publications, Inc; 1991.
47. Carstensen L, Isaacowitz D. Taking time seriously: a theory of socioemotional selectivity. Am Psychol 1999;54:165-81.
48. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 1992;267: 1244-52.
49. Miller GE, Chen E, Sze J, Marin T, Arevalo JM, Doll R, Ma R, Cole SW. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-[kappa] B signaling. Biol Psychiatry 2008; 64:226-72.
50. Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 2003;160:1554-65.
51. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860-7.
52. Scrivo R, Vasile M, Bartosiewicz I, Valesini G. Inflammation as "common soil" of the multifactorial diseases. Autoimmun Rev 2011;10:369-74.
53. Miller GE, Kemeny ME, Taylor SE, Cole SW, Visscher BR. Social relationships and immune processes in HIV seropositive gay and bisexual men. Ann Behav Med 1997;19:139-51.
54. Nathan P. A Guide to Treatments That Work. New York: Oxford University Press; 2007.
55. Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology. Ann Rev Psychol 2002;53:83-107.
56. Miller GE, Chen E, Cole SW. Health psychology: developing biologically plausible models linking the social world and physical health. Ann Rev Psychol 2009;60:501-24.
57. Gunthert KC, Cohen LH, Armeli S. The role of neuroticism in daily stress and coping. J Pers Soc Psychol 1999;77:1087-100.
58. Portella MJ, Harmer CJ, Flint J, Cowen P, Goodwin GM. Enhanced early morning salivary cortisol in neuroticism. Am J Psychiatry 2005;162: 807-9.
59. Costa PT, McCrae RR. Revised Neo Personality Inventory (Neo PI-R) and Neo Five-Factor Inventory (Neo-FFI) Professional Manual. Odessa, FL: Psychological Assessment Resources; 1992.