Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7422-7425

  Umehara, Masahiro ^a   Negishi, Takayuki ^a   Tashiro, Tomoko ^a   Nakao, Yoichi ^b   Kimura, Junji ^a  

^a AOYAMA GAKUIN UNIVERSITY   (Japan)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

Cyclodepsipeptide; Cytotoxic activity; Kulokekahilide 2; Structure activity relationship

Indexed keywords

CYCLODEPSIPEPTIDE; CYTOTOXIC AGENT; KULOKEKAHILIDE 2; KULOKEKAHILIDE 2 DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL VIABILITY; CHIRALITY; CYCLIZATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLLUSC; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HAWAII; HUMANS; MCF-7 CELLS; MOLECULAR CONFORMATION; MOLLUSCA; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 84870252626     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.058     Document Type: Article

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