Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7456-7460

  Lee, Kyeong ^a   Goo, Ja Il ^b   Jung, Hwa Young ^b   Kim, Minkyoung ^b   Boovanahalli, Shanthaveerappa K ^a   Park, Hye Ran ^c   Kim, Mun Ock ^c   Kim, Dong Hyun ^d   Lee, Hyun Sun ^c   Choi, Yongseok ^b  

^a Dongguk University   (South Korea)

^b Korea University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

Benzimidazole; DGAT; DGAT inhibitors; Obesity; Triglycerides; Type II diabetes

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; CHOLESTEROL; DIACYLGLYCEROL ACYLTRANSFERASE; DIACYLGLYCEROL ACYLTRANSFERASE INHIBITOR; ENZYME INHIBITOR; FURFURYLAMINE BENZIMIDAZOLE CARBOXAMIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIPID DIET; LIVER MICROSOME; NONHUMAN; OBESITY; RAT; WEIGHT REDUCTION;

ANIMALS; BENZIMIDAZOLES; DIACYLGLYCEROL O-ACYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; MICE; MICE, OBESE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; OBESITY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

MUS; RATTUS;

EID: 84870252419     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.046     Document Type: Article

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