Continuous pellet coating in a Wurster fluidized bed process

Chemical Engineering Science

Volumn 86, Issue , 2013, Pages 87-98

  Hampel, N ^a   Buck A ^a   Peglow, M ^a   Tsotsas, E ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Coating; Continuous process; Fluidized bed; Granulation; Population balance modeling; Wurster apparatus

Indexed keywords

FLUIDIZED BEDS; GRANULATION; SODIUM;

ACTIVE INGREDIENTS; BATCH-WISE; CHEMICAL APPLICATIONS; COATED PRODUCTS; COATING AGENTS; COATING PROCESS; CONTINUOUS MODE; CONTINUOUS OPERATION; CONTINUOUS PROCESS; FLUIDIZED BED COATING; IMPROVED PROCESS; MULTI-LAYER-COATING; PELLET COATINGS; POPULATION BALANCE MODELING; POPULATION BALANCES; REDUCED COST; SINGLE STAGE; SODIUM BENZOATE; WURSTER; WURSTER COATER;

COATINGS;

EID: 84870250698     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2012.05.034     Document Type: Article

References (26)

1. Arimoto M., Ichikawa H., Fukumori Y. Microencapsulation of water-soluble macromolecules with acrylic terpolymers by the Wurster coating process for colon-specific drug delivery. Powder Technol. 2004, 141:177-186.
2. Becher R., Schlünder E. Fluidized bed granulation: gas flow, particle motion and moisture distribution. Chem. Eng. Process. 1997, 36:261-269.
3. Bertin D., Cotabarren I., Bucalá V., Piña J. Analysis of the product granulometry, temperature and mass flow of an industrial multichamber fluidized bed urea granulator. Powder Technol. 2011, 206:122-131.
4. Börner M., Peglow M., Tsotsas E. Particle residence times in fluidized bed granulation equipments. Chem. Eng. Technol. 2011, 37:1116-1122.
5. Bück A., Klaunick G., Kumar J., Peglow M., Tsotsas E. Numerical simulation of particulate processes for control and estimation by spectral methods. AIChE J. 2011, 10.1002/aic.12757.
6. Christensen F., Bartelsen P. Qualitative description of the Wurster-based fluid-bed coating process. Drug Dev. Ind. Pharm. 1997, 23(5):451-463.
7. Drechsler J., Peglow M., Heinrich S., Ihlow M., Mörl L. Investigating the dynamic behaviour of fluidized bed spray granulation processes applying numerical simulation tools. Chem. Eng. Sci. 2005, 60:3817-3833.
8. Ennis B., Tardos G., Pfeffer R. A microlevel-based characterization of granulation phenomena. Powder Technol. 1991, 65:257-272.
9. Heinrich S., Peglow M., Ihlow M., Henneberg M., Mörl L. Analysis of the start-up process in continuous fluidized bed spray granulation by population balance modelling. Chem. Eng. Sci. 2002, 57:4369-4390.
10. Geldart D. Types of gas fluidization. Powder Technol. 1973, 7:285-292.
11. Koren B. A robust upwind discretisation method for advection, diffusion and source terms. Notes Numer. Fluid Mech. 1993, 45:117-138.
12. KuShaari K., Pandey P., Turton Y. Monte Carlo simulations to determine coating uniformity in a Wurster fluidized bed coating process. Powder Technol. 2006, 166:81-90.
13. Li J., Freireich B., Wassgren C., Litster J. A general compartment-based population balance model for particle coating and layered granulation. AIChE J. 2011, 10.1002/aic.12678.
14. Maronga S., Wnukowski P. Modelling of the three-domain fluidized-bed particulate coating process. Chem. Eng. Sci. 1997, 17:2915-2925.
15. Molerus O., Hoffmann H. Darstellung von Windsichterkurven durch ein stochastisches Modell. Chem. Ing. Tech. 1969, 45:340-344.
16. Mörl, L., Heinrich, S., Peglow, M., 2007. Fluidized bed spray granulation. In: A.D., Salman, M.J., Hounslow, J.P.K., Seville (Eds.), Handbook of Powder Technology, vol. 11, pp. 21-188.
17. Peglow M., Cunäus U., Tsotsas E. An analytical solution of population balance equations for continuous fluidized bed drying. Chem. Eng. Sci. 2011, 66:1916-1922.
18. Radichkov R., Müller T., Kienle A., Heinrich S., Peglow M., Mörl L. A numeric bifurcation analysis of continuous fluidized bed spray granulation with external product classification. Chem. Eng. Process. 2006, 45:826-837.
19. Ramkrishna D. Population Balances: Theory and Application to Particulate Systems in Engineering 2000, Academic Press, New York.
20. Salman A., Hounslow M., Seville J. Granulation. Handbook of Powder Technology 2007, 11. Elsevier, Amsterdam.
21. Ström D., Karlsson S., Folestad S., Björn I., Laurell T., Nilsson J., Rasmuson A. A new device for coating single particles under controlled conditions. Chem. Eng. Sci. 2005, 60:4647-4653.
22. Teunou E., Ponchet D. Batch and continuous fluid bed coating. J. Food Eng. 2002, 53:325-340.
23. Tzika M., Alexandridou S., Kiparissides C. Evaluation of the morphological and release characteristics of coated fertilizer granules produced in a Wurster fluidized bed. Powder Technol. 2003, 132:16-24.
24. Uhlemann H., Mörl L. Wirbelschicht-Sprühgranulation 2000, Springer, Berlin.
25. Vreman A., Lare C., Hounslow M. A basic population balance model for fluid bed spray granulation. Chem. Eng. Sci. 2009, 64:4389-4398.
26. Wurster, D.E., 1966. Particle Coating Process. US Patent No. 3,253,944, Wisconsin Alumni Research Foundation.