Pregabalin misuse-related issues; Intake of large dosages, drug-smoking allegations, and possible association with myositis: Two case reports

Journal of Clinical Psychopharmacology

Volumn 32, Issue 6, 2012, Pages 839-840

  Carrus, Dario ^a   Schifano, Fabrizio ^b  

^a Department of Mental Health ^*  (Italy)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; BENZODIAZEPINE DERIVATIVE; CANNABIS; COCAINE; OLANZAPINE; PREGABALIN;

ADULT; AGGRESSION; ANGER; ANTISOCIAL BEHAVIOR; ANXIETY; BIPOLAR DISORDER; CASE REPORT; DRUG ABUSE; DRUG DOSE INCREASE; DRUG MISUSE; GENERAL PRACTITIONER; GENERALIZED ANXIETY DISORDER; HUMAN; LETTER; MYALGIA; MYOSITIS; NATIONAL HEALTH SERVICE; NEUROPATHIC PAIN; PRESCRIPTION; PRIORITY JOURNAL; SMOKING; TABLET;

ADULT; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MYOSITIS; PRESCRIPTION DRUG MISUSE; SMOKING;

EID: 84870242036     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e318272864d     Document Type: Letter

References (18)

1. Filipetto FA, Zipp CP, Coren JS. Potential for pregabalin abuse or diversion after past drug-seeking behavior. J Am Osteopath Assoc. 2010;110:605-607.
2. Grosshans M, Mutschler J, Hermann D, et al. Pregabalin abuse, dependence, and withdrawal: A case report. Am J Psychiatry. 2010;167:869.
3. Schwan S, Sundström A, Stjernberg E, et al. A signal for an abuse liability for pregabalinVresults from the Swedish spontaneous adverse drug reaction reporting system. Eur J Clin Pharmacol. 2010;66: 947-953.
4. Westin AA, StrLm EJ. Yes, pregabalin can be abused! Tidsskr Nor Laegeforen. 2010;130:2108.
5. Schifano F, D'Offizi S, Piccione M, et al. Is there a recreational misuse potential for pregabalin? Analysis of anecdotal online reports in comparison with related gabapentin and clonazepam data. Psychother Psychosom. 2011;80:118-122.
6. EMCDDAYEuropol 2009 Annual Report on the implementation of Council Decision 2005/387/JHA; Annex 2VNew psychoactive substances reported to the EMCDDA and Europol for the first time in 2009 under the terms of Council. Available at: Http://www.emcdda.europa.eu/html.cfm/index33227EN.html. Accessed May 25, 2011.
7. Naranjo CA, Busto U, Sellers EM. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-245. (Pubitemid 12149145)
8. British National Formulary, 2011.
9. Available at: Http://bnf.org/bnf/bnf/61/129077.htm?q=pregabalin&t= search&ss= text&p=1. Accessed on May 25, 2011.
10. McEvoy GK. American Hospital Formulary Service. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists; 2007.
11. Littlejohn C, Baldacchino A, Schifano F, et al. Internet pharmacies and online prescription drug sales: A cross-sectional study. Drugs Educ Prev Policy. 2005;12:75-80. (Pubitemid 40131982)
12. Schifano F, Deluca P, Baldacchino A, et al. Drugs on the web; the Psychonaut 2002 EU project. Progr Neuropsychopharmacol Biol Psychiatry. 2006;30:640-646.
13. Nymdelger S, Nieberg K. Pregabalin: A neuromodulator for the treatment of neuropathic pain, generalized anxiety disorders and cystic fibrosis syndrome. Medizin Monatssch Pharmazeuten. 2007;30:396-400. (Pubitemid 350104973)
14. Martinotti G, Di Nicola M, Tedeschi D, et al. Efficacy and safety of pregabalin in alcohol dependence. Adv Ther. 2008;25: 608-618.
15. Oulis P, Konstantakopoulos G, Kouzoupis AV, et al. Pregabalin in the discontinuation of long-term benzodiazepines' use. Hum Psychopharmacol Clin Exp. 2008;23:337-340. (Pubitemid 351982672)
16. Martinotti G, di Nicola M, Frustaci A, et al. Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: A multi-centre, randomized, single-blind comparison trial. Addiction. 2010;105:288-299.
17. Martinotti G, Di Nicola M, Tedeschi D, et al. Pregabalin versus naltrexone in alcohol dependence: A randomised, double-blind, comparison trial. J Psychopharmacol. 2010;9:1367-1374.
18. Hadley SJ, Mandel FS, Schweizer E. Switching from long-term benzodiazepine therapy to pregabalin in patients with generalized anxiety disorder: A double-blind, placebo-controlled trial. J Psychopharmacol. 2012;26:461-470.