Statins reduce appropriate implantable cardioverter-defibrillator shocks in ischemic cardiomyopathy with no benefit in nonischemic cardiomyopathy

American Journal of Therapeutics

Volumn 19, Issue 6, 2012, Pages 413-418

  Contractor, Tahmeed ^a   Beri, Abhimanyu ^a   Gardiner, Joseph ^b   Ardhanari, Sivakumar ^c   Thakur, Ranjan ^d  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b LOMA LINDA UNIVERSITY   (United States)

^c University of Missouri   (United States)

^d Thoracic and Cardiovascular Institute   (United States)

Author keywords

appropriate shocks; implantable cardioverter defibrillators; Statins; ventricular fibrillation; ventricular tachycardia

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

AGED; ARTICLE; CONTROLLED STUDY; DRUG USE; FEMALE; FOLLOW UP; HEART EJECTION FRACTION; HEART VENTRICLE ARRHYTHMIA; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; ISCHEMIC CARDIOMYOPATHY; MAJOR CLINICAL STUDY; MALE; NONISCHEMIC CARDIOMYOPATHY; PRIORITY JOURNAL; RISK FACTOR;

AGED; AGED, 80 AND OVER; CARDIOMYOPATHIES; COHORT STUDIES; DEFIBRILLATORS, IMPLANTABLE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; RETROSPECTIVE STUDIES; TIME FACTORS;

EID: 84870239498     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e318217a509     Document Type: Article

References (12)

1. Davignon J. Beneficial cardiovascular pleiotropic effects of statins. Circulation. 2004;109:III39-43. (Pubitemid 38786442)
2. Liu YB, Lee YT, Pak HN, et al. Effects of simvastatin on cardiac neural and electrophysiologic remodeling in rabbits with hypercholesterolemia. Heart Rhythm. 2009; 6:69-75.
3. Beri A, Contractor T, Khasnis A, et al. Statins and the reduction of sudden cardiac death: antiarrhythmic or antiischemic effect? Am J Cardiovasc Drugs. 2010;10:155-164.
4. Beri A, Contractor T, Gardiner JC, et al. Reduction in the intensity rate of appropriate shocks for ventricular arrhythmias with statin therapy. J Cardiovasc Pharmacol. 2010;56:190-194.
5. Vyas AK, Guo H, Moss AJ, et al. Reduction in ventricular tachyarrhythmias with statins in the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II. J Am Coll Cardiol. 2006;47:769-773. (Pubitemid 43243099)
6. Mitchell LB, Powell JL, Gillis AM, et al. Are lipid-lowering drugs also antiarrhythmic drugs? An analysis of the Antiarrhythmics versus Implantable Defibrillators (AVID) trial. J Am Coll Cardiol. 2003;42:81-87. (Pubitemid 36760765)
7. Goldberger JJ, Subacius H, Schaechter A, et al. Effects of statin therapy on arrhythmic events and survival in patients with nonischemic dilated cardiomyopathy. J Am Coll Cardiol. 2006;48:1228-1233. (Pubitemid 44363151)
8. Coleman CI, Kluger J, Bhavnani S, et al. Association between statin use and mortality in patients with implantable cardioverter-defibrillators and left ventricular systolic dysfunction. Heart Rhythm. 2008;5:507-510.
9. Desai H, Aronow WS, Tsai FS, et al. Statins reduce appropriate cardioverter-defibrillator shocks and mortality in patients with heart failure and combined cardiac resynchronization and implantable cardioverter- defibrillator therapy. J Cardiovasc Pharmacol Ther. 2009; 14:176-179.
10. Crisby M, Nordin-Fredriksson G, Shah PK, et al. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization. Circulation. 2001;103:926-933. (Pubitemid 32183796)
11. Pirro M, Schillaci G, Romagno PF, et al. Influence of shortterm rosuvastatin therapy on endothelial progenitor cells and endothelial function. J Cardiovasc Pharmacol Ther. 2009;14:14-21.
12. Tousoulis D, Bosinakou E, Kotsopoulou M, et al. Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina. Int J Cardiol. 2006;106:333-337. (Pubitemid 41766634)