What drives the clustering of membrane-bound Ras?

Small GTPases

Volumn 3, Issue 4, 2012, Pages

  Li, Zhenlong ^a   Gorfe, Alemayehu A ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Lipid anchor; Lipid sorting; Membrane domain; Peptide association; Ras nanocluster

Indexed keywords

PEPTIDE; RAS PROTEIN; NANOMATERIAL;

CARBOXY TERMINAL SEQUENCE; CATALYSIS; CLUSTER ANALYSIS; ENTHALPY; ENTROPY; LIPID ANALYSIS; LIPID BILAYER; MOLECULAR SIZE; MOLECULAR STABILITY; NOTE; PROTEIN ASSEMBLY; PROTEIN DOMAIN; ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; COMPUTER SIMULATION; METABOLISM;

CELL MEMBRANE; COMPUTER SIMULATION; LIPID BILAYERS; MODELS, MOLECULAR; NANOSTRUCTURES; PEPTIDES; RAS PROTEINS;

EID: 84870233152     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.21829     Document Type: Note

References (37)

1. Hancock JF. Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol 2003; 4:373-84; PMID:12728271; http://dx.doi.org/10.1038/ n rm1105.
2. Abankwa D, Gorfe AA, Hancock JF. Ras nano-clusters: molecular structure and assembly. Semin Cell Dev Biol 2007; 18:599-607; PMID:17897845; http://dx.doi.org/10.1016/j.semcdb.2007.08.003.
3. Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 2008; 9:517-31; PMID:18568040; http://dx.doi.org/10.1038/ nrm2438.
4. Rotblat B, Prior IA, Muncke C, Parton RG, Kloog Y, Henis YI, et al. Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol Cell Biol 2004; 24:6799-810; PMID:15254246; http://dx.doi.org/10.1128/ MCB.24.15.6799-6810.2004.
5. Plowman SJ, Muncke C, Parton RG, Hancock JF. H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc Natl Acad Sci USA 2005; 102:15500-5; PMID:16223883; http:// dx.doi.org/10.1073/pnas.0504114102.
6. Weise K, Kapoor S, Denter C, Nikolaus J, Opitz N, Koch S, et al. Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms. J Am Chem Soc 2011; 133:880-7; PMID:21141956; http://dx.doi.org/10.1021/ja107532q.
7. Weise K, Triola G, Brunsveld L, Waldmann H, Winter R. Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains. J Am Chem Soc 2009; 131:1557-64; PMID:19133719; http://dx.doi.org/10.1021/ ja808691r.
8. Weise K, Triola G, Janosch S, Waldmann H, Winter R. Visualizing association of lipidated signaling proteins in heterogeneous membranes-partitioning into subdomains, lipid sorting, interfacial adsorption, and protein association. Biochim Biophys Acta 2010; 1798: 1409-17.
9. Hancock JF, Magee AI, Childs JE, Marshall CJ. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 1989; 57:1167-77; PMID:2661017; http://dx.doi.org/10.1016/0092-8674(89)90054-8.
10. Cox AD, Der CJ. Ras history: The saga continues. Small GTPases 2010; 1:2-27; PMID:21686117; http://dx.doi.org/10.4161/sgtp.1.1.12178.
11. Gorfe A A, Babakhani A, McCammon JA. Free Energy Profile of H-ras Membrane Anchor upon Membrane Insertion. Angew Chem Int Ed 2007; 119:8382-5; http://dx.doi.org/10.1002/ange.200702379.
12. Gorfe AA, Pellarin R, Caflisch A. Membrane localization and flexibility of a lipidated ras peptide studied by molecular dynamics simulations. J Am Chem Soc 2004; 126:15277-86; PMID:15548025; http:// dx.doi.org/10.1021/ja046607n.
13. Gorfe AA, McCammon JA. Similar membrane affinity of mono- and Di-S-acylated ras membrane anchors: a new twist in the role of protein lipidation. J Am Chem Soc 2008; 130:12624-5; PMID:18761454; http://dx.doi.org/10.1021/ja805110q.
14. Gorfe AA, Baron R, McCammon JA. Water-membrane partition thermodynamics of an amphi-philic lipopeptide: an enthalpy-driven hydrophobic ef fect. Biophys J 2008; 95:3269-77; PMID:18621822; http://dx.doi.org/10.1529/biophysj.108.136481.
15. Brunsveld L, Waldmann H, Huster D. Membrane binding of lipidated ras peptides and proteins-the structural point of view. Biochim Biophys Acta 2009; 1788:273-88.
16. Huster D, Vogel A, Katzka C, Scheidt HA, Binder H, Dante S, et al. Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy. J Am Chem Soc 2003; 125:4070-9; PMID:12670227; http://dx.doi. org/10.1021/ja0289245.
17. Wang TY, Leventis R, Silvius JR. Partitioning of lipidated peptide sequences into liquid-ordered lipid domains in model and biological membranes. Biochemistry 2001; 40:13031-40; PMID:11669641; http://dx.doi.org/10.1021/bi0112311.
18. Silvius JR. Partitioning of membrane molecules between raft and non-raft domains: insights from model-membrane studies. Biochim Biophys Acta 2005; 1746:193-202.
19. Abankwa D, Hanzal-Bayer M, Ariotti N, Plowman SJ, Gorfe AA, Parton RG, et al. A novel switch region regulates H-ras membrane orientation and signal output. EMBO J 2008; 27:727-35; PMID:18273062; http://dx.doi.org/10.1038/emboj.2008.10.
20. Janosi L, Li Z, Hancock JF, Gorfe AA. Organization, Dynamics and Segregation of Ras Nanoclusters in Membrane Domains Proceedings of the National Academy of Sciences 2012; 109:8097-102.
21. Gorfe AA, Hanzal-Bayer M, Abankwa D, Hancock JF, McCammon JA. Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer. J Med Chem 2007; 50:674-84; PMID:17263520; http://dx.doi.org/10.1021/jm061053f.
22. Abankwa D, Gorfe AA, Inder K, Hancock JF. Ras membrane orientation and nanodomain localization generate isoform diversity. Proc Natl Acad Sci USA 2010; 107:1130-5; PMID:20080631; http://dx.doi. org/10.1073/pnas.0903907107.
23. Gorfe AA, Babakhani A, McCammon JA. H-ras protein in a bilayer: interaction and structure perturbation. J Am Chem Soc 2007; 129:12280-6; PMID:17880077; http://dx.doi.org/10.1021/ ja 0 739 49 v.
24. Vogel A, Tan KT, Waldmann H, Feller SE, Brown MF, Huster D. Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations. Biophys J 2007; 93:2697-712; PMID:17557790; http://dx.doi.org/10.1529/ biophysj.107.104562.
25. Janosi L, Gorfe AA. Segregation of negatively charged phospholipids by the polycationic and farnesylated membrane anchor of Kras. Biophys J 2010; 99:3666-74; PMID:21112291; http://dx.doi.org/10.1016/j. bpj.2010.10.031.
26. Morozova D, Guigas G, Weiss M. Dynamic structure formation of peripheral membrane proteins. PLoS Comput Biol 2011; 7:e1002067; PMID:21731477; http://dx.doi.org/10.1371/journal.pcbi.1002067.
27. Li S, Zhang X, Wang W. Cluster formation of anchored proteins induced by membrane-mediated interaction. Biophys J 2010; 98:2554-63; PMID:20513399; http://dx.doi.org/10.1016/j. bpj.2010.02.032.
28. Yue T, Li S, Zhang X, Wang W. The relationship between membrane curvature generation and clustering of anchored proteins: a computer simulation study. Soft Matter 2010; 6:6109-18; http://dx.doi. org/10.1039/c0sm00418a.
29. Vogel A, Katzka CP, Waldmann H, Arnold K, Brown MF, Huster D. Lipid modifications of a Ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR. J Am Chem Soc 2005; 127:12263-72; PMID:16131204; http: //dx.doi.org/10.1021/ja051856c.
30. Putzel GG, Schick M. Phenomenological model and phase behavior of saturated and unsaturated lipids and cholesterol. Biophys J 2008; 95:4756-62; PMID:18708463; http://dx.doi.org/10.1529/bio-physj.108.136317.
31. Schäfer LV, de Jong DH, Holt A, Rzepiela AJ, de Vries AH, Poolman B, et al. Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes. Proc Natl Acad Sci USA 2011; 108:1343-8; PMID:21205902; http: //dx.doi.org/10.1073/pnas.1009362108.
32. Yethiraj A, Weisshaar JC. Why are lipid rafts not observed in vivo? Biophys J 2007; 93:3113-9; PMID:17660324; http://dx.doi.org/10.1529/bio-physj.106.101931.
33. Elliott R, Szleifer I, Schick M. Phase diagram of a ternary mixture of cholesterol and saturated and unsatu-rated lipids calculated from a microscopic model. Phys Rev Lett 2006; 96:098101; PMID:16606318; http: //dx.doi.org/10.1103/PhysRevLett.96.098101.
34. de Meyer FJM, Venturoli M, Smit B. Molecular simulations of lipid-mediated protein-protein interactions. Biophys J 2008; 95:1851-65; PMID:18487292; http: //dx.doi.org/10.1529/biophysj.107.124164.
35. Venturoli M, Smit B, Sperotto MM. Simulation studies of protein-induced bilayer deformations, and lipid-induced protein tilting, on a mesoscopic model for lipid bilayers with embedded proteins. Biophys J 2005; 88:1778-98; PMID:15738466; http://dx.doi. org/10.1529/biophysj.104.050849.
36. Domanski J, Marrink SJ, Schäfer LV. Transmembrane helices can induce domain formation in crowded model membranes. Biochim Biophys Acta 2011; 1818:984-94.
37. Meilhac N, Destainville N. Clusters of proteins in biomembranes: insights into the roles of interaction potential shapes and of protein diversity. J Phys Chem B 2011; 115:7190-9; PMID:21528886; http://dx.doi. org/10.1021/jp1099865.