Total ginsenosides of radix ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues

Molecules

Volumn 17, Issue 11, 2012, Pages 12746-12757

  Wang, Jing Rong ^a,b   Zhou, Hua ^a,b   Yi, Xiao Qin ^b   Jiang, Zhi Hong ^a,b   Liu, Liang ^a,b  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Cardio protection; Energy metabolism; Proteomics; Total ginsenosides

Indexed keywords

ADENINE PHOSPHORIBOSYLTRANSFERASE; CARDIOTONIC AGENT; GINSENOSIDE; HERBACEOUS AGENT; MICROTUBULE ASSOCIATED PROTEIN; MUSCLE PROTEIN; OXIDOREDUCTASE; PROTEOME; SP22 PROTEIN, RAT;

ANIMAL; ARTICLE; CHEMISTRY; CITRIC ACID CYCLE; DRUG EFFECT; ENERGY METABOLISM; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HEART MUSCLE; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; MALE; METABOLISM; PANAX; PLANT ROOT; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ADENINE PHOSPHORIBOSYLTRANSFERASE; ANIMALS; CARDIOTONIC AGENTS; CITRIC ACID CYCLE; DRUGS, CHINESE HERBAL; ENERGY METABOLISM; GENE EXPRESSION; GINSENOSIDES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MUSCLE PROTEINS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXIDOREDUCTASES; PANAX; PLANT ROOTS; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84870216991     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules171112746     Document Type: Article

References (15)

1. Ferdinandy, P.; Schulz, R.; Baxter, G.F. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, Preconditioning, And postconditioning. Pharmacol. Rev. 2007, 8, 418-458.
2. Hobbs, A.; Foster, P.; Prescott, C.; Scotland, R.; Ahluwalia, A. Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation 2004, 110, 1231-1235.
3. Schulz, R.; Kelm M.; Heusch, G. Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc. Res. 2004, 61, 402-413.
4. Christensen, L.P. Ginsenosides: Chemistry, Biosynthesis, Analysis, and Potential Health Effects. Adv. Food Nutr. Res. 2009, 55, 1-73.
5. Zhou, H.; Hou, S.Z.; Luo, P.; Zeng, B.; Wang, J.R.; Wong, Y.F.; Jiang, Z.H.; Liu, L. Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism. J. Ethnopharmacol. 2011, 135, 287-298.
6. Scott, G.I.; Colligan, P.B. Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: Role of nitric oxide. Br. J. Pharmacol. 2001, 134, 1159-1165.
7. Kang, S.Y.; Schini-Kerth, V.B. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci. 2001, 56, 1577-1586.
8. Yi, X.Q.; Wang, J.-R.; Li, T.; Wong, V.K.W.; Luo, P.; Hou S.Z.; Zeng, B.; Wong, I.Y.F.; Jiang, Z.-H.; Liu, L.; et al. Total Ginsenosides of Asian ginseng Increase Coronary Perfusion Flow of the Ischemia-reperfusion Injury Rat Heart in Lagendorff System through Activation of Akt-eNOS Signaling and Regulation of Cardiac Energy. Phytomedicine 2010, 17, 1006-1015.
9. Dawson, D.M.; Goodfriend, T.L.; Kaplan, N.O. Lactic dehydrogenase: Function of the two types. Science 1964, 143, 929-993.
10. Stanleym, W.C.; Lopaschuk, G.D.; Hall, J.L.; McCormack, J.G. Regulation of myocardial carbohydrate metabolim uder normal and ischemic conditions, Potential for pharmacological interventions. Cardiovasc. Res. 1997, 33, 243-257.
11. Goo, C.K.; Lim, H.Y.; Ho, Q.S.; Too, H.-P.; Clement, M.-V.; Wong, K.P. PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1. PLoS One 2012, 7, e45806.
12. Finlay, D.K. Regulation of glucose metabolism in T cells: New insight into the role of phosphoinositide 3-kinases. Front. Immun. 2012, 3, 247.
13. Chang, M.; Hamilton, J.A.; Scholz, G.M.; Elsegood, C.L. Glycolytic control of adjuvant-induced macrophage survival: Role of PI3K, MEK1/2, And Bcl-2. J. Leukoc. Biol. 2009, 85, 947-956.
14. Keith, R.J.; Haberzettl, P.; Vladykovskaya, E.; Hill, B.G.; Kaiserova, K.; Srivastava, S.; Barski, O.; Bhatnagar, A. Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts. Chem. Biol. Interact. 2009, 178, 242-249.
15. Son, N.-H.; Ananthakrishnan, R.; Yu, S.; Khan, R.S.; Jiang, H.; Ji, R.; Akashi, H.; Li, Q.; O'Shea, K.; Homma, S.; Goldberg, I.J.; et al. Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia. PLoS One 2012, 7, e46549.