Prednisolone conjugated polypropylene imine dendritic architecture confers reducing hemolytic toxicity- a comparative study

International Journal of Drug Development and Research

Volumn 4, Issue 2, 2012, Pages 188-194

  Karthikeyan, Ramadoss ^a   Kumar, Palanirajan Vijayaraj ^b  

^a ACHARYA NAGARJUNA UNIVERSITY   (India)

^b UCSI UNIVERSITY   (Malaysia)

Author keywords

Hemolytic toxicity; PEGylation; Polypropyleneimine dendrimer; Prednisolone

Indexed keywords

DENDRIMER; POLYPROPYLENE IMINE; PREDNISOLONE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HEMOLYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 84870211738     PISSN: None     EISSN: 09759344     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Liu M.J, Frechet J.M.J, Designing dendrimers for drug delivery. Pharm. Sci.Technol. Today 1999; 2:393-401.
2. Shakthivel T, Florence A.T, Dendrimers and dendrons: facets of pharmaceutical nanotechnology. Drug Deliv. Technol 2003; 3: 73-78.
3. Tomalia D.A, Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog. Polym. Sci 2005; 30:294-324.
4. Cheng Y, Xu Z., Xu M. Ma. T., Dendrimers as drug carriers: applications in different routes of drug administration. J. Pharm. Sci 2008; 97:123-143.
5. Domanski D.M, Bryszewska M, Salamonczyk G. Preliminary evaluation of the behavior of fifth-generation thiophosphate dendrimer in biological systems. Biomacromolecules 2004; 5: 2007-2012.
6. Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv. Drug Deliv. Rev. 2005; 57: 2215-2237.
7. De Brabender-Van Den Berg and Meijer, E. M. Poly (propylene imine) dendrimers: large scale synthesis by heterogeneously catalyzed hydrogenation. Angew Chem Int Ed Engl. 1993; 32(a):1665-1688,
8. Bhadra D, Yadav A.K, Bhadra S and Jain N.K. Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting. Int J Pharm 2005; 295: 221-233.
9. Veronese F.M, Caliceti P, Pastorin Schiavon O, Sartore L.J. Enzyme surface modification by polymers for improved delivery. Control.Rel 1989; 10: 145.
10. Li Y, Cheng Y, Xu T. Design, synthesis and potent pharmaceutical applications of glycodendrimers: a mini review. Curr Drug Discov Technol. 2007; 4: 246-54.