Effect of melatonin on seizure frequency in intractable epilepsy: A pilot study

Journal of Child Neurology

Volumn 27, Issue 12, 2012, Pages 1524-1528

  Goldberg Stern, Hadassa ^a,b   Oren, Heftsiba ^b,c   Peled, Nir ^d   Garty, Ben Zion ^a,b  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c MEDICAL CORPS   (Israel)

^d RABIN MEDICAL CENTER   (Israel)

Author keywords

antiepileptic effect; epilepsy; melatonin; sleep

Indexed keywords

MELATONIN; PLACEBO;

ACTIMETRY; ADOLESCENT; ADULT; ARTICLE; BEDTIME DOSAGE; CHILD; CHILD BEHAVIOR; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOCAL EPILEPSY; GENERALIZED EPILEPSY; GRAND MAL EPILEPSY; HUMAN; INTRACTABLE EPILEPSY; MALE; MYOCLONUS EPILEPSY; NEUROPHARMACOLOGY; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; SEIZURE; SLEEP PARAMETERS; SLEEP QUALITY;

ACTIGRAPHY; ADOLESCENT; ADULT; ANTIOXIDANTS; CHILD; CROSS-OVER STUDIES; EPILEPSY; FEMALE; HUMANS; MALE; MELATONIN; PILOT PROJECTS; REACTION TIME; SEIZURES; SLEEP; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 84870201140     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073811435916     Document Type: Article

References (31)

1. Brzezinski A. Melatonin in humans. New Engl J Med. 1997 ; 336: 186-195 (Pubitemid 27034965)
2. Dodge N, Wilson G. Melatonin for treatment of sleep disorders in children with developmental disabilities. J Child Neurol. 2001 ; 16: 581-584 (Pubitemid 32798881)
3. Ross C, Davis P, Whitehouse W. Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study. Dev Med Child Neurol. 2002 ; 44: 339-344 (Pubitemid 34516399)
4. Peled N, Shorer Z, Peled E, Pillar G. Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia. 2001 ; 42: 1208-1210 (Pubitemid 32947944)
5. Smits M, Nagtegaal E, Van der Heijden J, et al. Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. J Child Neurol. 2001 ; 16: 86-92 (Pubitemid 32390169)
6. Pillar G, Shahar E, Peled N, et al. Melatonin improves sleep-wake patterns in psychomotor retarded children. Pediatr Neurol. 2000 ; 23: 225-228
7. Jan JE. The treatment of sleep disorders with melatonin. Dev Med Child Neurol. 1994 ; 36: 97-107 (Pubitemid 24038931)
8. Palm L, Blennow G, Wetterberg L. Long-term melatonin treatment in blind children and young adults with circadian sleep- wake disturbances. Dev Med Child Neurol. 1997 ; 39: 319-325 (Pubitemid 27271709)
9. Braam W, Smits MG, Didden R, et al. Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Dev Med Child Neurol. 2009 ; 51: 340-349
10. Anton-Tay F. Melatonin: effects on brain function. Adv Biochem Psychopharmacol. 1974 ; 11: 315-324
11. Scalise A, Desiato MT, Gigli GL, et al. Increasing cortical excitability: a possible explanation for the proconvulsant role of sleep deprivation. Sleep. 2006 ; 29: 1595-1598 (Pubitemid 44936468)
12. Fariello RG, Bubenik GA, Grown GM, Grota LJ. Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology. 1977 ; 27: 567-570 (Pubitemid 8133893)
13. Golombek DA, Fernández Duque D, De Brito Sánchez MG, et al. Time-dependent anticonvulsant activity of melatonin in hamsters. Eur J Pharmacol. 1992 ; 210: 253-258
14. Niles LP, Pickering DS, Arciszewski MA. Effect of chronic melatonin administration of GABA and diazepam binding in rat brain. J Neural Transm. 1987 ; 70: 117-124
15. Castroviejo DA, Rosenstein RE, Romeo HE, Cardinali DP. Changes in gamma-aminobutyric acid high affinity binding to cerebral cortex membranes after pinealectomy or melatonin administration to rats. Neuroendocrinology. 1986 ; 43: 24-31 (Pubitemid 16122186)
16. Muñoz-Hoyos A, Sánchez-Forte M, Molina-Carballo A, et al. Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence. J Child Neurol. 1998 ; 13: 501-509 (Pubitemid 28483712)
17. Borowicz KK, Kamiński R, Gasior M, et al. Influence of melatonin upon the protective action of conventional anti-epileptic drugs against maximal electroshock in mice. Eur Neuropsychopharmacol. 1999 ; 9: 185-190 (Pubitemid 29114922)
18. Gupta M, Aneja S, Kohli K. Add-on melatonin improves behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial. J Child Neurol. 2005 ; 20: 112-115 (Pubitemid 40484849)
19. Gupta M, Gupta YK, Agarwal S, et al. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsia. 2004 ; 45: 1636-1639 (Pubitemid 39648290)
20. Gupta M, Gupta YK, Agarwal S, et al. A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. Br J Clin Pharmacol. 2004 ; 58: 542-547 (Pubitemid 39540459)
21. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia. 1981 ; 22: 489-501
22. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia. 1989 ; 30: 389-399
23. Ross C, Morris B, Whitehouse W. Melatonin treatment of sleep-wake cycle disorders in children and adolescents. Dev Med Child Neurol. 1999 ; 41: 850
24. Molina-Carballo A, Muñoz-Hoyos A, Reiter RJ, et al. Utility of high dose of melatonin as adjunctive therapy in a child with severe myoclonic epilepsy: two years' experience. J Pineal Res. 1997 ; 23: 97-105 (Pubitemid 127731744)
25. Paprocka J, Dec R, Jamroz E, Marszal E. Melatonin and childhood refractory epilepsy-a pilot study. Med Sci Monit. 2010 ; 16: CR389 - CR396
26. Bazil CW, Short D, Crispin D, Zheng W. Patients with intractable epilepsy have low melatonin, which increases following seizures. Neurology. 2000 ; 56: 1746-1748
27. Pandi-Perumal SR, Smith M, Spence W, et al. Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2006 ; 31: 1-11
28. Sheldon SH. Pro-convulsant effects of oral melatonin in disabled children. Lancet. 1998 ; 351: 1254 (Pubitemid 28181974)
29. Coppola G, Iervolino G, Mastrosimone M, et al. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain Dev. 2004 ; 26: 373-376 (Pubitemid 38953323)
30. van Geijlswijk IM, van der Heijden KB, Egberts AC, et al. Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia. Psychopharmacology. 2010 ; 212 (3). 379-391
31. Braam W, van Geijlswijk IM, Keijzer H, et al. Loss of response to melatonin treatment is associated with slow melatonin metabolism. J Intellect Disab Res. 2010 ; 54: 547-555