Managing the prodrome of schizophrenia

Handbook of Experimental Pharmacology

Volumn 212, Issue , 2012, Pages 125-134

  Fleischhacker, W Wolfgang ^a   Simma, Alexander M ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Antidepressants; Antipsychotics; CBT; Early intervention; High risk; Omega 3 fatty acids; Prevention; Prodrome; Prophylaxis; Psychotherapy; Schizophrenia

Indexed keywords

AMISULPRIDE; ANTIDEPRESSANT AGENT; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; MOOD STABILIZER; OLANZAPINE; OMEGA 3 FATTY ACID; PLACEBO; RISPERIDONE; TOCOPHEROL; NEUROLEPTIC AGENT;

ARTICLE; BEHAVIOR THERAPY; CONTROLLED CLINICAL TRIAL (TOPIC); DRUG DOSE REDUCTION; EXTRAPYRAMIDAL SYMPTOM; FATIGUE; HUMAN; LOW DRUG DOSE; PATIENT COMPLIANCE; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOEDUCATION; PSYCHOSIS; PSYCHOSOCIAL CARE; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; SIDE EFFECT; UNSPECIFIED SIDE EFFECT; WEIGHT GAIN; ANIMAL; COGNITIVE THERAPY; PRODROMAL SYMPTOM; REVIEW;

ANIMALS; ANTIPSYCHOTIC AGENTS; COGNITIVE THERAPY; CONTROLLED CLINICAL TRIALS AS TOPIC; HUMANS; PRODROMAL SYMPTOMS; SCHIZOPHRENIA;

EID: 84870180851     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-25761-2_5     Document Type: Article

References (26)

1. Addington J, Epstein I, Liu L, French P, Boydell K, Zipursky RB (2011a) A randomized controlled trial of cognitive behavioral therapy for individuals at clinical high risk of psychosis. Schizophr Res 125(1):54-61
2. Addington J, Cornblatt BA, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Walker EF, Woods SW, Heinssen R (2011b) At clinical high risk for psychosis: outcome for nonconverters. Am J Psychiatry 168(8):800-805
3. Amminger G, Schäfer M, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE (2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67(2): 146-154
4. Bechdolf A, Wagner M, Veith V, Ruhrmann S, Pukrop R, Brockhaus-Dumke A, Berning J, Stamm E, Janssen B, Decker P, Bottlender R, Möller HJ, Gaebel W, Maier W, Klosterkötter J (2007) Randomized controlled multicentre trial of cognitive behaviour therapy in the early initial prodromal state: effects on social adjustment post treatment. Early Interv Psychiatry 1(1):71-78
5. Bechdolf A, Wagner M, Ruhrmann S, Harrigan S, Putzfeld V, Pukrop R, Brockhaus-Dumke A, Berning J, Janssen B, Decker P, Bottlender R, Maurer K, Möller H-J, Gaebel W, Häfner H, Maier W, Klosterkötter J (2012) Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry 200(1):22-29
6. Berger GE, Wood SJ, Wellard RM, Proffitt TM, McConchie M, Amminger GP, Jackson GD, Velakoulis D, Pantelis C, McGorry PD (2008) Ethyl-eicosapentaenoic acid in first-episode psychosis: a 1H-MRS study. Neuropsychopharmacology 33(10):2467-2473
7. Cornblatt BA, Lencz T, Smith CW, Olsen R, Auther AM, Nakayama E, Lesser ML, Tai JY, Shah MR, Foley CA, Kane JM, Correll CU (2007) Can antidepressants be used to treat the schizophrenia prodrome? Results of a prospective, naturalistic treatment study of adolescents. J Clin Psychiatry 68(4):546-557 (Pubitemid 46663037)
8. Dell'osso B, Altamura AC (2010) Duration of untreated psychosis and duration of untreated illness: new vistas. CNS Spectr 15(4):238-246
9. Fenton WS, Hibbeln J, Knable M (2000) Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biol Psychiatry 47(1):8-21 (Pubitemid 30016075)
10. Fusar-Poli P, Bonoldi I, Yung AR, Borgwardt S, Kempton MJ, Valmaggia L, Barale F, Caverzasi E, McGuire P (2012) Predecting psychosis: meta-analysis of transition outcomes in individuals in high clinical risk. Arch Gen Psychiatry 69(3):220-229
11. Gross G, Huber G (1985) Psychopathology of basic stages of schizophrenia in view of formal thought disturbances. Psychopathology 18(2-3):115-125 (Pubitemid 16224271)
12. Howes OD, Bose SK, Turkheimer F, Valli I, Egerton A, Valmaggia LR, Murray RM, McGuire P (2011) Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study. Am J Psychiatry 168(12):1311-1317
13. Koutsouleris N, Borgwardt S, Meisenzahl EM, Bottlender R, Möller HJ, Riecher-Rössler A (2011) Disease prediction in the at-risk mental state for psychosis using neuroanatomical biomarkers: results from the FePsy study. Schizophr Bull, 10 (Schizophr Bull first published online 2011 November 10), doi: 10.1093/schbul/sbr145
14. Malla AK, Bodnar M, Joober R, Lepage M (2011) Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis. Schizophr Res 125(1):13-20
15. McGlashan TH, Zipursky RB, Perkins D, Addington J, Miller T, Woods SW, Hawkins KA, Hoffman RE, Preda A, Epstein I, Addington D, Lindborg S, Trzaskoma Q, Tohen M, Breier A (2006) Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis. Am J Psychiatry 163(5):790-799 (Pubitemid 44464525)
16. McGorry PD, Yung AR, Phillips LJ, Yuen HP, Francey S, Cosgrave EM, Germano D, Bravin J, McDonald T, Blair A, Adlard S, Jackson H (2002) Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry 59(10):921-928
17. Morrison AP, French P, Walford L, Lewis SW, Kilcommons A, Green J, Parkers S, Bentall RP (2004) Cognitive therapy for the prevention of psychosis in people at ultra-high risk: randomised controlled trial. Br J Psychiatry 185:291-297 (Pubitemid 39331330)
18. Morrison AP, French P, Parker S, Roberts M, Stevens H, Bentall RP, Lewis SW (2007) Three-year follow-up of a randomized controlled trial of cognitive therapy for the prevention of psychosis in people at ultrahigh risk. Schizophr Bull 33(3):682-687 (Pubitemid 47343709)
19. Nordentoft M, Thorup A, Petersen L, Ohlenschlaeger J, Melau M, Christensen TØ, Krarup G, Jørgensen P, Jeppesen P (2006) Transition rates from schizotypal disorder to psychotic disorder for first-contact patients included in the OPUS trial. A randomized clinical trial of integrated treatment and standard treatment. Schizophr Res 83(1):29-40
20. Phillips LJ, McGorry PD, Yuen HP, Ward J, Donovan K, Kelly D, Francey SM, Yung AR (2007) Medium term follow-up of a randomized controlled trial of interventions for young people at ultra high risk of psychosis. Schizophr Res 96(1-3):25-33 (Pubitemid 47494628)
21. Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC (1991) Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature 353 (6340):164-167 (Pubitemid 21912481)
22. Ruhrmann S, Schultze-Lutter F, Klosterkötter J (2003) Early detection and intervention in the initial prodromal phase of schizophrenia. Pharmacopsychiatry 36(Suppl 3):S162-S167 (Pubitemid 38085132)
23. Ruhrmann S, Bechdolf A, Kühn K-U, Wagner M, Schultze-Lutter F, Janssen B, Maurer K, Häfner H, Gaebel W, Möller HJ, Maier W, Klosterkötter J; LIPS study group (2007) Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis. Br J Psychiatry 191(51):88-95
24. World Health Organisation (2001) World Health Report 2001 - Mental health: new understanding, new hope. Geneva
25. Yung AR, Phillips LJ, Yuen HP, McGorry PD (2004) Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res 67:131-142 (Pubitemid 38251443)
26. Yung AR, Phillips LJ, Nelson B, Francey SM, PanYuen H, Simmons M, Ross ML, Kelly D, Baker K, Amminger GP, Berger G, Thompson AD, Thampi A, McGorry PD (2011) Randomized controlled trial of interventions for young people at ultra high risk for psychosis. J Clin Psychiatry 72(4):430-440