-
1
-
-
77950409731
-
New targeted therapies in the treatment of patients with metastatic melanoma
-
Mackiewicz J, Kwinta L. New targeted therapies in the treatment of patients with metastatic melanoma. Contemp Oncol 2010; 14: 15-22.
-
(2010)
Contemp Oncol
, vol.14
, pp. 15-22
-
-
Mackiewicz, J.1
Kwinta, L.2
-
2
-
-
84871329035
-
-
National Cancer Registry
-
National Cancer Registry http://www.onkologia.org.pl/pl/p/11.
-
-
-
-
3
-
-
77950469665
-
Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma
-
Thymosin Melanoma Investigation Group
-
Maio M, Mackiewicz A, Testori A, et al.; Thymosin Melanoma Investigation Group. Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma. J Clin Oncol 2010; 28: 1780-7.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1780-1787
-
-
Maio, M.1
Mackiewicz, A.2
Testori, A.3
-
4
-
-
84871262732
-
Immunotargeting of melanoma, current management of malignant melanoma
-
Ming Y Cao (ed.). Available from
-
Mackiewicz J, Mackiewicz A. Immunotargeting of melanoma, current management of malignant melanoma. Ming Y Cao (ed.). InTech 2011. Available from: http://www.intechopen.com/articles/show/title/immunotargeting-of-melanoma.
-
InTech 2011
-
-
Mackiewicz, J.1
Mackiewicz, A.2
-
5
-
-
84871312706
-
-
http://www.clinicaltrials.gov/ct2/show/NCT00636168?term= ipilimumab+adjuvant+melanoma&rank=1A.
-
-
-
-
6
-
-
84871304995
-
-
http://www.clinicaltrials.gov/ct2/show/NCT00796445?term= MAGE+DERMA+melanoma&rank=2.
-
-
-
-
7
-
-
84864258996
-
A landscape of driver mutations in melanoma
-
Hodis E, Watson IR, Kryukov GV, et al. A landscape of driver mutations in melanoma. Cell 2012; 150: 251-63.
-
(2012)
Cell
, vol.150
, pp. 251-263
-
-
Hodis, E.1
Watson, I.R.2
Kryukov, G.V.3
-
8
-
-
84859464241
-
Therapeutic implications of KIT in me - Lanoma
-
Postow MA, Carvajal RD. Therapeutic implications of KIT in me - lanoma. Cancer J 2012; 18: 137-41.
-
(2012)
Cancer J
, vol.18
, pp. 137-141
-
-
Postow, M.A.1
Carvajal, R.D.2
-
9
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
DOI 10.1038/nature00766
-
Davies H, Bignelli GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54. (Pubitemid 34716871)
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmleri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
10
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
DOI 10.1056/NEJMoa050092
-
Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alteration in melanoma. N Engl J Med 2005; 353: 2135-47. (Pubitemid 41653105)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
Patel, H.N.4
Busam, K.J.5
Kutzner, H.6
Cho, K.-H.7
Aiba, S.8
Brocker, E.-B.9
LeBoit, P.E.10
Pinkel, D.11
Bastian, B.C.12
-
11
-
-
79952601620
-
BRAF mutations in cutaneus melanoma are independently associated with age, anatomic site of the primary tumor, ant the degree of solar elastosis at the primary tumor site
-
Bauer J, Büttner P, Murali R, Okamoto I, Kolaitis NA, Landi MT, Scolyer RA, Bastian BC. BRAF mutations in cutaneus melanoma are independently associated with age, anatomic site of the primary tumor, ant the degree of solar elastosis at the primary tumor site. Pigment Cell Melanoma Res 2011; 24: 345-351.
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, pp. 345-351
-
-
Bauer, J.1
Büttner, P.2
Murali, R.3
Okamoto, I.4
Kolaitis, N.A.5
Landi, M.T.6
Scolyer, R.A.7
Bastian, B.C.8
-
12
-
-
80052358465
-
Treatment implications of the emerging molecular classification system for melanoma
-
Romano E, Schwartz GK, Chapman PB, Wolchock JD, Carvajal RD. Treatment implications of the emerging molecular classification system for melanoma. Lancet Oncol 2011; 12: 913-22.
-
(2011)
Lancet Oncol
, vol.12
, pp. 913-922
-
-
Romano, E.1
Schwartz, G.K.2
Chapman, P.B.3
Wolchock, J.D.4
Carvajal, R.D.5
-
13
-
-
79551595779
-
Targeting BRAF for patients with melanoma
-
Arkenau HT, Kefford R, Long GV. Targeting BRAF for patients with melanoma. Br J Cancer 2011; 104: 392-8.
-
(2011)
Br J Cancer
, vol.104
, pp. 392-398
-
-
Arkenau, H.T.1
Kefford, R.2
Long, G.V.3
-
14
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 2012; 366: 707-14.
-
(2012)
N Engl J Med
, vol.366
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
-
15
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
BRIM-3 Study Group
-
Chapman PB, Hauschild A, Robert C, et al.; BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011; 364: 2507-16.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
16
-
-
84865068182
-
Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma
-
abstr. 8502
-
Chapman PB, Hauschild A, Robert C et al. Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma. J Clin Oncol 2012; 30 (suppl): abstr. 8502.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
17
-
-
84864313889
-
An open-label, multicenter safety study of vemurafenib (PLX4032, RO5185426) in patients with metastatic melanoma
-
abstr. 8517
-
Larkin JMG, Queirolo P, Aranc AM et al. An open-label, multicenter safety study of vemurafenib (PLX4032, RO5185426) in patients with metastatic melanoma. J Clin Oncol 2012; 30 (suppl): abstr. 8517.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Larkin, J.M.G.1
Queirolo, P.2
Aranc, A.M.3
-
19
-
-
84864291364
-
BREAK-MB: A phase II study assessing overall intracranial response rate (OIRR) to dabrafenib (GSK2118436) in patients (pts) with BRAF V600E/k mutation-positive melanoma with brain metastases (mets)
-
abstr. 8501
-
Kirkwood JM, Long GV, Trefzer U, et al. BREAK-MB: A phase II study assessing overall intracranial response rate (OIRR) to dabrafenib (GSK2118436) in patients (pts) with BRAF V600E/k mutation-positive melanoma with brain metastases (mets). J Clin Oncol 2012; 30 (suppl): abstr. 8501.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Kirkwood, J.M.1
Long, G.V.2
Trefzer, U.3
-
20
-
-
84859471412
-
Targeting mutant BRAF in Melanoma. Current status and future development of combination therapy strategies
-
Kudchadkar R, Paraiso KH, Smalley K. Targeting mutant BRAF in Melanoma. Current status and future development of combination therapy strategies. Cancer J 2012; 18: 124-31.
-
(2012)
Cancer J
, vol.18
, pp. 124-131
-
-
Kudchadkar, R.1
Paraiso, K.H.2
Smalley, K.3
-
21
-
-
84865092227
-
600E/K mutant advanced or metastatic melanoma (MM)
-
abstr. LBA8509
-
600E/K mutant advanced or metastatic melanoma (MM). J Clin Oncol 2012; 30 (suppl): abstr. LBA8509.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
-
22
-
-
77953276524
-
Recovery of phosphor-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
-
Paraiso KH, Fedorenko IV, Cantini LP, et al. Recovery of phosphor-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 2010; 102: 1724-30.
-
(2010)
Br J Cancer
, vol.102
, pp. 1724-1730
-
-
Paraiso, K.H.1
Fedorenko, I.V.2
Cantini, L.P.3
-
23
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM, Boehm JS, Kim SY, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 2010; 468: 968-72.
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
-
24
-
-
80051625929
-
Dissecting therapeutic resistance to inhibition in melanoma by genomic profiling
-
Wagle N, Emery C, Berger MF, et al. Dissecting therapeutic resistance to inhibition in melanoma by genomic profiling. J Clin Oncol 2011; 29: 3085-96.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
Berger, M.F.3
-
25
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerazation of aberrantly spliced BRAF (V600E)
-
Poulikakos PI, Persuad Y, Janakiraman M, et al. RAF inhibitor resistance is mediated by dimerazation of aberrantly spliced BRAF (V600E). Nature 2011; 480: 387-90.
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persuad, Y.2
Janakiraman, M.3
-
26
-
-
84864278914
-
InfanteUpdated safety and efficacy results from a phase I/II study of the oral BRAF inhibitor dabrafenib (GSK2118436) combined with the oral MEK 1/2 inhibitor trametinib (GSK1120212) in patients with BRAF-naive metastatic melanoma
-
abstr. 8510
-
Weber JS, Flaherty KT, Jeffrey R. InfanteUpdated safety and efficacy results from a phase I/II study of the oral BRAF inhibitor dabrafenib (GSK2118436) combined with the oral MEK 1/2 inhibitor trametinib (GSK1120212) in patients with BRAF-naive metastatic melanoma. J Clin Oncol 2012; 30 (suppl): abstr. 8510.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Weber, J.S.1
Flaherty, K.T.2
Jeffrey, R.3
-
27
-
-
84871320876
-
A phase II trial of dasatinib in patients with unresectable locally advanced or stage IV mucosal, acral, and solar melanomas: An Eastern Cooperative Oncology Group study (E2607)
-
abstr. 8522
-
Kalinsky K, Lee SJ, Lawrence DP, et al. A phase II trial of dasatinib in patients with unresectable locally advanced or stage IV mucosal, acral, and solar melanomas: An Eastern Cooperative Oncology Group study (E2607). J Clin Oncol 2012; 30 (suppl): abstr. 8522.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Kalinsky, K.1
Lee, S.J.2
Lawrence, D.P.3
-
28
-
-
84871337067
-
-
http://www.clinicaltrials.gov/ct2/results?term=NCT01028222.
-
-
-
-
29
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363: 711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
30
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011; 364: 2517-26.
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
-
31
-
-
84871271558
-
-
Long-term survival in advanced melanoma patients treated with ipilimumab at 10 mg/kg: ongoing analyses from completed phase II Trials. poster 116
-
Maio M, Lebbé C, Sileni VCh, et al. Long-term survival in advanced melanoma patients treated with ipilimumab at 10 mg/kg: ongoing analyses from completed phase II Trials. ESMO Congress 2009; poster 116.
-
ESMO Congress 2009
-
-
Maio, M.1
Lebbé, C.2
Sileni, V.3
-
32
-
-
84871346550
-
-
Three-year survival rates for patients with advanced melanoma who received ipilimumab at 10 mg/kg in Phase II Trials. poster P-0020
-
Maio M, Lebbé C, Neyns B, et al. Three-year survival rates for patients with advanced melanoma who received ipilimumab at 10 mg/kg in Phase II Trials. Congress - Perspectives in Melanoma XIV, Amsterdam 2010; poster P-0020.
-
Congress - Perspectives in Melanoma XIV, Amsterdam 2010
-
-
Maio, M.1
Lebbé, C.2
Neyns, B.3
-
33
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
-
Wolchok JD, Neyns B, Linette G, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010; 11: 155-64.
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
-
34
-
-
77955256254
-
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: Amulticenter single-arm phase II study
-
O'Day SJ, Maio M, Chiarion-Sileni V, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: amulticenter single-arm phase II study. Ann Oncol 2010; 21: 1712-17.
-
(2010)
Ann Oncol
, vol.21
, pp. 1712-1717
-
-
O'Day, S.J.1
Maio, M.2
Chiarion-Sileni, V.3
-
35
-
-
69949095926
-
A randomized,double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
-
O'Day SJ, Maio M, Chiarion-Sileni V, et al. A randomized,double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res 2009; 15: 5591-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5591-5598
-
-
O'Day, S.J.1
Maio, M.2
Chiarion-Sileni, V.3
-
36
-
-
79953653271
-
Treatment and side effect management of CTLA-4 antibody therapy in metastatic melanoma
-
Kähler KC, Hauschild A. Treatment and side effect management of CTLA-4 antibody therapy in metastatic melanoma. J Dtsch Dermatol Ges 2011; 9: 277-86.
-
(2011)
J Dtsch Dermatol Ges
, vol.9
, pp. 277-286
-
-
Kähler, K.C.1
Hauschild, A.2
-
38
-
-
79955021779
-
Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010
-
Hersey P, Smalley KS, Weeraratna A, et al. Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010. Pigment Cell Melanoma Res 2011; 24: 1: e1-15.
-
(2011)
Pigment Cell Melanoma Res
, vol.24
, Issue.1
-
-
Hersey, P.1
Smalley, K.S.2
Weeraratna, A.3
-
39
-
-
58749105795
-
Overcoming immunologic tolerance to melanoma: Targeting CTLA-4 with ipilimumab (MDX-010)
-
Weber J. Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with ipilimumab (MDX-010). Oncologist 2008; 13 Suppl 4: 16-25.
-
(2008)
Oncologist
, vol.13
, Issue.SUPPL. 4
, pp. 16-25
-
-
Weber, J.1
-
40
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
DOI 10.1158/1078-0432.CCR-07-0187
-
Downey SG, Klapper JA, Smith FO, et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 2007; 13 (22 Pt 1): 6681-8. (Pubitemid 350206804)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.22
, pp. 6681-6688
-
-
Downey, S.G.1
Klapper, J.A.2
Smith, F.O.3
Yang, J.C.4
Sherry, R.M.5
Royal, R.E.6
Kammula, U.S.7
Hughes, M.S.8
Allen, T.E.9
Levy, C.L.10
Yellin, M.11
Nichol, G.12
White, D.E.13
Steinberg, S.M.14
Rosenberg, S.A.15
-
41
-
-
61349114199
-
Ipilimumab: Controversies in its development, utility and autoimmune adverse events
-
Weber J. Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother 2009; 58: 823-30.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 823-830
-
-
Weber, J.1
-
42
-
-
37049008206
-
Kinetics of response to ipilimumab (MDX-010) in patients with stage III/IV melanoma
-
abstr. 8525
-
Hamid O, Urba WJ, YellinM. et al. Kinetics of response to ipilimumab (MDX-010) in patients with stage III/IV melanoma. J Clin Oncol 2007; 25 (Suppl. 25): abstr. 8525.
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 25
-
-
Hamid, O.1
Urba, W.J.2
Yellin, M.3
-
44
-
-
84892808887
-
Ipilimumab (Ipi) expanded access program (EAP) for patients (pts) with stage III/IV melanoma: 10 mg/kg cohort interim results
-
abstr. 8508
-
O Hamid, WJ Hwu, JM Richards et al. Ipilimumab (Ipi) expanded access program (EAP) for patients (pts) with stage III/IV melanoma: 10 mg/kg cohort interim results. J Clin Oncol 2012; 30 (suppl): abstr. 8508.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Hamid, O.1
Hwu, W.J.2
Richards, J.M.3
-
45
-
-
84871296509
-
-
http://www.clinicaltrials.gov/ct2/show/NCT01515189?term= ipilimumab+melanoma+10+mg+3+mg&rank=1.
-
-
-
-
46
-
-
84865092225
-
Hypersensitivity skin reactions in melanoma patients treated with vemurafenib after ipilimumab therapy
-
abstr. 8515
-
Harding JJ, Lacouture ME, Pulitzer M, et al. Hypersensitivity skin reactions in melanoma patients treated with vemurafenib after ipilimumab therapy. J Clin Oncol 2012; 30 (suppl): abstr. 8515.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Harding, J.J.1
Lacouture, M.E.2
Pulitzer, M.3
-
47
-
-
84892808887
-
CA184-161: A phase I/II trial of vemurafenib and ipilimumab in patients with BRAF V600 mutation-positive metastatic melanoma
-
abstr. TPS8603
-
Ribas A, Hodi FS, Kurland JF, et al. CA184-161: A phase I/II trial of vemurafenib and ipilimumab in patients with BRAF V600 mutation-positive metastatic melanoma. J Clin Oncol 2012; 30 (suppl): abstr. TPS8603.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Ribas, A.1
Hodi, F.S.2
Kurland, J.F.3
-
48
-
-
84860446616
-
Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial
-
Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol 2012; 13: 459-65.
-
(2012)
Lancet Oncol
, vol.13
, pp. 459-465
-
-
Margolin, K.1
Ernstoff, M.S.2
Hamid, O.3
-
49
-
-
84865072027
-
The NIBIT-M1 trial: Activity of ipilimumab plus fotemustine in patients with melanoma and brain metastases
-
abstr. 8529
-
Maio M, Testori A, Ascierto PA, et al. The NIBIT-M1 trial: Activity of ipilimumab plus fotemustine in patients with melanoma and brain metastases. J Clin Oncol 2012; 30 (suppl): abstr. 8529.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Maio, M.1
Testori, A.2
Ascierto, P.A.3
-
50
-
-
61449159816
-
A phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
abstr. 9023
-
Kirkwod JM, Lorigan P, Hersey P, et al. A phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. J Clin Oncol 2008; (suppl. 26): abstr. 9023.
-
(2008)
J Clin Oncol
, Issue.SUPPL. 26
-
-
Kirkwod, J.M.1
Lorigan, P.2
Hersey, P.3
-
51
-
-
55949137090
-
Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma
-
abstr. LBA9011
-
Ribas A, Hauschild A, Kefford R, et al. Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma. J Clin Oncol 2008; (suppl. 26): abstr. LBA9011.
-
(2008)
J Clin Oncol
, Issue.SUPPL. 26
-
-
Ribas, A.1
Hauschild, A.2
Kefford, R.3
-
52
-
-
46949108188
-
Phase II trial combination biotherapy of high-dose interferon alfa-2b and tremelimumab for recurrent inoperable stage III or IV melanoma
-
abstr. 9009
-
Tarhini AA, Moschos SS, Schlesselman JJ, et al. Phase II trial combination biotherapy of high-dose interferon alfa-2b and tremelimumab for recurrent inoperable stage III or IV melanoma. J Clin Oncol 2008; (suppl. 26): abstr. 9009.
-
(2008)
J Clin Oncol
, Issue.SUPPL. 26
-
-
Tarhini, A.A.1
Moschos, S.S.2
Schlesselman, J.J.3
-
53
-
-
34447646310
-
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
-
DOI 10.1016/j.immuni.2007.05.016, PII S1074761307003287
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand interacts specifically with the B7-1 costimulatory molecules to inhibit T cell responses. Immunity 2007; 27: 111-22. (Pubitemid 47089023)
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
54
-
-
84865097403
-
Clinical activity and safety of anti-PD-1 (BMS-936558, MDX-1106) in patients with advanced melanoma (MEL)
-
abstr. 8507
-
Hodi FS, Sznol M, McDermott DF, et al. Clinical activity and safety of anti-PD-1 (BMS-936558, MDX-1106) in patients with advanced melanoma (MEL). J Clin Oncol 2012; 30 (suppl): abstr. 8507.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Hodi, F.S.1
Sznol, M.2
McDermott, D.F.3
-
55
-
-
84865073276
-
Phase I trial of extended-dose anti-PD-1 antibody BMS-936558 with a multipeptide vaccine for previously treated stage IV melanoma
-
abstr. 8582
-
Kudchadkar RR, Gallenstein D, Martinez AJ, et al. Phase I trial of extended-dose anti-PD-1 antibody BMS-936558 with a multipeptide vaccine for previously treated stage IV melanoma. J Clin Oncol 2012; 30 (suppl): abstr. 8582.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Kudchadkar, R.R.1
Gallenstein, D.2
Martinez, A.J.3
-
56
-
-
55949113750
-
Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
-
abstr. 3007
-
Sznol M, Hodi FS, Margolin K. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). J Clin Oncol 2008; (suppl): abstr. 3007.
-
(2008)
J Clin Oncol
, Issue.SUPPL.
-
-
Sznol, M.1
Hodi, F.S.2
Margolin, K.3
-
57
-
-
84871335980
-
-
http://www.clinicaltrials.gov/ct2/show/NCT00612664?term= BMS-663513&rank=6.
-
-
-
-
58
-
-
33947506186
-
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
-
DOI 10.1200/JCO.2006.08.3311
-
Vonderheide RH, Flaherty K, Khalil M, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 2006; 25: 876-83. (Pubitemid 350002889)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.7
, pp. 876-883
-
-
Vonderheide, R.H.1
Flaherty, K.T.2
Khalil, M.3
Stumacher, M.S.4
Bajor, D.L.5
Hutnick, N.A.6
Sullivan, P.7
Mahany, J.J.8
Gallagher, M.9
Kramer, A.10
Green, S.J.11
O'Dwyer, P.J.12
Running, K.L.13
Huhn, R.D.14
Antonia, S.J.15
-
59
-
-
84871293628
-
-
http://www.clinicaltrials.gov/ct2/show/NCT00607048?term= CP-870%2C893&rank=3.
-
-
-
-
60
-
-
34548249596
-
An international, randomized, phase III trial of bacillus Calmette-Guerin (BCG) plus allogeneic melanoma vaccine (MCV) or placebo after complete resection of melanoma metastatic or regional or distant sites
-
abstr. 8508
-
Morton DL, Mozzillo N, Thompson JF, et al. An international, randomized, phase III trial of bacillus Calmette-Guerin (BCG) plus allogeneic melanoma vaccine (MCV) or placebo after complete resection of melanoma metastatic or regional or distant sites. J Clin Oncol 2007; (suppl): abstr. 8508.
-
(2007)
J Clin Oncol
, Issue.SUPPL.
-
-
Morton, D.L.1
Mozzillo, N.2
Thompson, J.F.3
-
61
-
-
0036895111
-
Active immunotherapy of metastatic melanoma with allogeneic melanoma lysates and interferon alpha
-
Vaishampayan U, Abrams J, Darrah D, Jones V, Mitchell MS. Active immunotherapy of metastatic melanoma with allogeneic melanoma lysates and interferon alpha. Clin Cancer Res 2002; 8: 3696-6701.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3696-6701
-
-
Vaishampayan, U.1
Abrams, J.2
Darrah, D.3
Jones, V.4
Mitchell, M.S.5
-
62
-
-
77958570368
-
Gene-modified cellular vaccines: Technologic aspects and clinical problems
-
Mackiewicz J, Mackiewicz A. Gene-modified cellular vaccines: technologic aspects and clinical problems. Transplant Proc 2010; 42: 3287-92.
-
(2010)
Transplant Proc
, vol.42
, pp. 3287-3292
-
-
Mackiewicz, J.1
Mackiewicz, A.2
-
63
-
-
84861052254
-
Long-term survival of high-risk melanoma patients immunized with a hyper-IL-6- Modified allogeneic whole-cell vaccine after complete resection
-
Mackiewicz A, Mackiewicz J, Wysocki PJ, et al. Long-term survival of high-risk melanoma patients immunized with a hyper-IL-6- modified allogeneic whole-cell vaccine after complete resection. Expert Opin Investig Drugs 2012; 21: 773-83.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 773-783
-
-
Mackiewicz, A.1
Mackiewicz, J.2
Wysocki, P.J.3
-
64
-
-
46749103710
-
Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial
-
DOI 10.1016/S0140-6736(08)61033-8, PII S0140673608610338
-
Eggermont AMM, Suciu S, Samtinam M, et al. Adjuvant therapy with pegylated interferon α-2b versus observation in resected stage III melanoma. Final results of EORTC 18891, a randomized phase 3 trial. Lancet 2008; 372: 117-26. (Pubitemid 351952257)
-
(2008)
The Lancet
, vol.372
, Issue.9633
, pp. 117-126
-
-
Eggermont, A.M.1
Suciu, S.2
Santinami, M.3
Testori, A.4
Kruit, W.H.5
Marsden, J.6
Punt, C.J.7
Sales, F.8
Gore, M.9
MacKie, R.10
Kusic, Z.11
Dummer, R.12
Hauschild, A.13
Musat, E.14
Spatz, A.15
Keilholz, U.16
-
65
-
-
53549105257
-
Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: A randomized multicenter trial of the German Dermatologic Cooperative Oncology Group
-
Eigentler TK, Radny P, Hauschild A, et al. Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group. Melanoma Res 2008; 18: 363-8.
-
(2008)
Melanoma Res
, vol.18
, pp. 363-368
-
-
Eigentler, T.K.1
Radny, P.2
Hauschild, A.3
-
66
-
-
0034772102
-
Double-blind trial of polyvalent, shed-antigen, melanoma vaccine
-
Bystryn JC, Zeleniuch-Jacquotte A, Oratz R, et al. Double-blind trial of polyvalent, shed-antigen, melanoma vaccine. Clin Cancer Res 2011: 1882-7.
-
(2011)
Clin Cancer Res
, pp. 1882-1887
-
-
Bystryn, J.C.1
Zeleniuch-Jacquotte, A.2
Oratz, R.3
-
67
-
-
84871312226
-
Surgery in stage IV melanoma patients: Results from a single institution
-
abstr. e19035
-
Pennacchioli E, Gandini S, Verrecchia F, et al. Surgery in stage IV melanoma patients: Results from a single institution. J Clin Oncol 2012; 30 (suppl): abstr. e19035.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Pennacchioli, E.1
Gandini, S.2
Verrecchia, F.3
-
68
-
-
0032546352
-
Dendritic cells and the control of immunity
-
DOI 10.1038/32588
-
Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-52. (Pubitemid 28155090)
-
(1998)
Nature
, vol.392
, Issue.6673
, pp. 245-252
-
-
Banchereau, J.1
Steinman, R.M.2
-
69
-
-
0030781916
-
Dendritic cells: Unique leukocyte populations which control the primary immune response
-
Hart DN. Dendritic cells: unique leukocyte populatons which control the primary immune response. Blood 1997; 90: 3245-87. (Pubitemid 27473395)
-
(1997)
Blood
, vol.90
, Issue.9
, pp. 3245-3287
-
-
Hart, D.N.J.1
-
70
-
-
33645325115
-
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: A randomized phase III trial of the DC study group of the DeCOG
-
Schadendorf D, Ugurel S, Schuler-Thurner B, et al. Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG. Ann Oncol 2006; 17: 563-70.
-
(2006)
Ann Oncol
, vol.17
, pp. 563-570
-
-
Schadendorf, D.1
Ugurel, S.2
Schuler-Thurner, B.3
-
71
-
-
54849437711
-
Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: Assessment of correlation between clinical response and vaccine parameters
-
Engel-Noerregaard L, Hansen TH, Andersen MH, Straten PT, Svane IM. Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters. Cancer Immunol Immunother 2009; 58: 1-14.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 1-14
-
-
Engel-Noerregaard, L.1
Hansen, T.H.2
Andersen, M.H.3
Straten, P.T.4
Svane, I.M.5
-
72
-
-
84865092226
-
Adjuvant dendritic cell (DC)-based vaccine therapy of melanoma patients
-
abstr. 2524
-
NN Petenko, IN Mikhaylova, GZ Chkadua, AY Baryshnikov, LV Demidov et al. Adjuvant dendritic cell (DC)-based vaccine therapy of melanoma patients. J Clin Oncol 2012; 30 (suppl): abstr. 2524.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Petenko, N.N.1
Mikhaylova, I.N.2
Chkadua, G.Z.3
Baryshnikov, A.Y.4
Demidov, L.V.5
|