Clinical presentation, immunohistochemistry and electron microscopy indicate neurofibromatosis type 2-associated gliomas to be spinal ependymomas

Neuropathology

Volumn 32, Issue 6, 2012, Pages 611-616

  Hagel, Christian ^a   Stemmer Rachamimov, Anat O ^e   Bornemann, Antje ^b   Schuhmann, Martin ^c   Nagel, Christoph ^c   Huson, Susan ^f   Evans, D Gareth ^g   Plotkin, Scott ^e   Matthies, Cordula ^d   Kluwe, Lan ^a   Mautner, Victor Felix ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b Institut für Hirnforschung   (Germany)

^c Universitätsklinik für Neurochirurgie   (Germany)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f ST MARY S HOSPITAL   (United Kingdom)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Electron microscopy; Ependymoma; Glioma; Immunohistochmistry; Neurofibromatosis type 2

Indexed keywords

EPITHELIAL MEMBRANE ANTIGEN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; ELECTRON MICROSCOPY; EPENDYMOMA; FEMALE; GENE MUTATION; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEUROFIBROMATOSIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPINAL EPENDYMOMA; SPINE TUMOR;

ADOLESCENT; ADULT; CHILD; DIAGNOSIS, DIFFERENTIAL; EPENDYMOMA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; NEUROFIBROMATOSIS 2; SPINAL CORD NEOPLASMS; YOUNG ADULT;

EID: 84870066174     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2012.01306.x     Document Type: Article

References (18)

1. Evans DG, Huson SM, Donnai D etal. A clinical study of type 2 neurofibromatosis. Q J Med 1992; 84: 603-618.
2. Evans DG. Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]. Genet Med 2009; 11: 599-610.
3. Hagel C, Lindenau M, Lamszus K, Kluwe L, Stavrou D, Mautner VF. Polyneuropathy in neurofibromatosis 2: clinical findings, molecular genetics and neuropathological alterations in sural nerve biopsy specimens. Acta Neuropathol 2002; 104: 179-187.
4. Lee M, Rezai AL, Freed DBS, Epstein F. Intramedullary spinal cord tumors in Neurofibromatosis. Neurosurgery 1996; 38: 32-37.
5. Mautner VF, Tatagiba M, Lindenau M etal. Spinal Tumors in patients with Neurofibromatosis Type 2: MR imaging study of frequency, multiplicity and variety. AJR 1995; 165: 951-955.
6. Patronas NJ, Courcoutsakis N, Bromley CM, Katzman GL, MacCollin M, Parry DM. Intramedullary and spinal canal tumors in patients with Neurofibromatosis 2: MR imaging findings and correlation with genotype. Radiology 2001; 218: 434-422.
7. Balasubramaniam A, Shannon P, Hodaie M, Laperriere N, Michaels H, Guha A. Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature. Neuro-Oncol 2007; 9: 447-453.
8. Rowe J, Grainger A, Walton L, Radatz M, Kemeny A. Safety of radiosurgery applied to conditions with abnormal tumor suppressor genes. Neurosurgery 2007; 60: 860-864.
9. Alonso ME, Bello MJ, Arjona D etal. Analysis of the NF2 gene in oligodendrogliomas and ependymomas. Cancer Genet Cytogenet 2002; 134: 1-5.
10. Ng HK, Lau KM, Tse JY etal. Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors. Neurosurgery 1995; 37: 764-773.
11. Rubio MP, Correa KM, Ramesh V etal. Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas. Cancer Res 1994; 54: 45-47.
12. National Institutes of Health Consensus Development Conference Statement on Neurofibromatosis. Arch Neurol 1987; 45: 575-579.
13. Kawano N, Yasui Y, Utsuki S, Oka H, Fujii K, Yamashina S. Light microscopic demonstration of the microlumen of ependymoma: a study of the usefulness of antigen retrieval for epithelial membrane antigen (EMA) immunostaining [published correction appears in Brain Tumor Pathol 2004; 21: 102-103]. Brain Tumor Pathol 2004; 21: 17-21.
14. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 2003; 17: 1090-1100.
15. McClatchey AI, Giovannini M. Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin. Genes Dev 2005; 19: 2265-2277.
16. Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol 2005; 29: 1164-1169.
17. Wiestler OD, von Siebenthal K, Schmitt HP, Feiden W, Kleihues P. Distribution and immunoreactivity of cerebral micro-hamartomas in bilateral acoustic neurofibromatosis (neurofibromatosis 2). Acta Neuropathol 1989; 79: 137-143.
18. Jay V, Edwards V, Varela-Stavrinou M, Rutka J. Unique intracerebral tumor with divergent differentiation in a patient presenting as NF2: report of a case with features of astrocytoma, ependymoma, and PNET. Ultrastruct Pathol 1997; 21: 57-71.