Validation of first trimester screening for trisomy 21 in singapore with reference to performance of nasal bone

Fetal Diagnosis and Therapy

Volumn 32, Issue 3, 2012, Pages 166-170

  Yeo, George Seow Heong ^a,b   Lai, Fon Min ^a   Wei, Xing ^a   Lata, Padma ^b   Tan, Doreen Tsai Hia ^b   Yong, Min Hwee ^a   Tan, Edward Teck Hoo ^a   Kwek, Kenneth Yung Chiang ^a  

^a KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^b Antenatal Diagnostic Center   (United States)

Author keywords

First trimester screening; Nasal bone; Trisomy 21

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BIOCHEMISTRY; BLOOD ANALYSIS; CHROMOSOME ABERRATION; DOWN SYNDROME; FALSE POSITIVE RESULT; FETUS; FIRST TRIMESTER SCREENING; HUMAN; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; NASAL BONE; NUCHAL TRANSLUCENCY MEASUREMENT; PRIORITY JOURNAL; RISK FACTOR; SCREENING; SINGAPORE; TRISOMY 21;

ADOLESCENT; ADULT; ALGORITHMS; BIOLOGICAL MARKERS; DOWN SYNDROME; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; MATERNAL AGE; MIDDLE AGED; NASAL BONE; NUCHAL TRANSLUCENCY MEASUREMENT; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PRENATAL DIAGNOSIS; RISK; SENSITIVITY AND SPECIFICITY; SINGAPORE; ULTRASONOGRAPHY, PRENATAL; YOUNG ADULT;

EID: 84870064267     PISSN: 10153837     EISSN: 14219964     Source Type: Journal    
DOI: 10.1159/000338656     Document Type: Article

References (17)

1. Nicolaides KH: Screening for fetal aneuploidies at 11 to 13 weeks. Prenat Diagn 2011;31:7-15.
2. Lai FM, Yeo GS: Down syndrome screening in Singapore - the effectiveness of a second trimester serum screening policy modelled on 29,360 pregnancies in KK Women's and Children's Hospital. Singapore Med J 1998;39:69-75. (Pubitemid 128518337)
3. Bindra R, Heath V, Liao A, Spencer K, Nicolaides KH: One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15,030 pregnancies. Ultrasound Obstet Gynecol 2002;20:219-225.
4. Spencer K, Souter V, Tul N, Snijders R, Nicolaides KH: A screening program for trisomy 21 at 10-14 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 1999;13:231-237. (Pubitemid 29248329)
5. Snijders RJ, Noble P, Sebire N, Souka A, Nicolaides KH: UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group. Lancet 1998;352:343-346. (Pubitemid 28352196)
6. Cicero S, Curcio P, Papageorghiou A, Sonek J, Nicolaides K: Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an observational study. Lancet 2001;358:1665-1667. (Pubitemid 33124323)
7. Nicolaides KH: Some thoughts on the true value of ultrasound. Ultrasound Obstet Gynecol 2007;30:671-674. (Pubitemid 47612687)
8. Nicolaides KH: Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol 2004;191:45-67. (Pubitemid 39077955)
9. Wald NJ, Rodeck C, Hackshaw AK, Walters J, Chitty L, Mackinson AM: First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS). J Med Screen 2003;10:56-104. (Pubitemid 36734906)
10. Malone FD, Canick JA, Ball RH, Nyberg DA, Comstock CH, Bukowski R, Berkowitz RL, Gross SJ, Dugoff L, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, Dukes K, Bianchi DW, Rudnicka AR, Hackshaw AK, Lambert- Messerlian G, Wald NJ, D'Alton ME: Firsttrimester or second-trimester screening, or both, for Down's syndrome. N Engl J Med 2005;353:2001-2011. (Pubitemid 41609093)
11. Cicero S, Dezerega V, Andrade E, Scheier M, Nicolaides KH: Learning curve for sonographic examination of the fetal nasal bone at 11-14 weeks. Ultrasound Obstet Gynecol 2003;22:135-137. (Pubitemid 36976378)
12. Senat MV, Bernard JP, Boulvain M, Ville Y: Intra- and interoperator variability in fetal nasal bone assessment at 11-14 weeks of gestation. Ultrasound Obstet Gynecol 2003;22:138-141. (Pubitemid 36976379)
13. Sonek JD, Cicero S, Neiger R, Nicolaides KH: Nasal bone assessment in prenatal screening for trisomy 21. Am J Obstet Gynecol 2006;195:1219-1230. (Pubitemid 44635344)
14. Cicero S, Rembouskos G, Vandecruys H, Hogg M, Nicolaides KH: Likelihood ratio for trisomy 21 in fetuses with absent nasal bone at the 11-14-week scan. Ultrasound Obstet Gynecol 2004;23:218-223. (Pubitemid 38365796)
15. Thia EW, Wei X, Tan DT, Lai XH, Zhang XJ, Oo SY, Yeo GS: Evaluation of an objective method of image assessment for first-trimester nasal bone. Ultrasound Obstet Gynecol 2011;38:533-537.
16. Hecht CA, Hook EB: The imprecision in rates of Down syndrome by 1-year maternal age intervals: a critical analysis of rates used in biochemical screening. Prenat Diagn 1994;14:729-738. (Pubitemid 24270721)
17. Snijders RJ, Sundberg K, Holzgreve W, Henry G, Nicolaides KH: Maternal age- and gestation- specific risk for trisomy 21. Ultrasound Obstet Gynecol 1999;13:167-170. (Pubitemid 29176889)