A prospective, open-label study to compare the efficacy and the safety of topical Loteprednol etabonate and topical flurbiprofen sodium in patients with post-operative inflammation after cataract extraction

Journal of Clinical and Diagnostic Research

Volumn 6, Issue 9, 2012, Pages 1499-1503

  Bannale, Sheshidhar G ^a   Pundarikaksha, H P ^b   Sowbhagya, H N ^b  

^a S NIJALINGAPPA MEDICAL COLLEGE   (India)

^b Kempegowda Institute of Medical Science   (India)

Author keywords

Anti inflammatory drugs; Cataract extraction; Loteprednol; Post operative inflammation

Indexed keywords

EYE DROPS; FLURBIPROFEN; LOTEPREDNOL;

ADULT; ANTERIOR EYE CHAMBER; AQUEOUS FLARE; AQUEOUS HUMOR; ARTICLE; CILIARY BODY; CILIARY CONGESTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; CORNEA EDEMA; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; EXTRACAPSULAR CATARACT EXTRACTION; EYE INFLAMMATION; EYE PAIN; FEMALE; HUMAN; INCISION; MALE; OPEN STUDY; POSTOPERATIVE INFLAMMATION; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; UNSPECIFIED SIDE EFFECT;

EID: 84870038587     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2012/4759.2543     Document Type: Article

References (18)

1. Harry J, Misson G. Immunity, Inflammation and Infection. In: Clinical Ophthalmic Pathology. New Delhi: Butterworth Heineman; 2001; 30-113.
2. Pavesion CE, Decory HH. The treatment of the ocular inflammatory conditions with Loteprednol etabonate. Brit J Ophthalmol 2008; 92:455-59.
3. Hayat AK, Abandan KA. Topical diclofenac versus dexamethasone after strabismus surgeries- A blind randomized clinical trial on the anti-inflammatory effect and the ocular hypertensive response. Indian J Ophthalmol 2007;55:271-75.
4. Manjoo SR, Suneetha N, Reji KT, Batt RR. Topical diclofenac sodium for the treatment of postoperative inflammation. Drugs 2007;67(9):1291-308.
5. Sihota R, Tondon R. Diseases of the Conjunctiva. In: Parson's Diseases of the Eye. 20th ed. Noida (India):Elsevier; 2008; 155-80.
6. Soon-Phaik C, Seng-Ei T, Meenakshi S, Donald TH. The post-operative inflammation: extracapsular cataract extraction versus phacoemulsification. Journal of Cataract Surgery 1995;25:1280-85.
7. Joseph NS, Robyn AP, Joyce EJ. Comparison of the efficacy and the safety of ketorolac Tromethaminen 0.5% and prednisolone acetate 1% after cataract surgeries. J Cataract Refract Surg 1999;25: 699-704.
8. Abelson MB, Butrus S. Corticosteroids in the Ophthalmic Practice. In: Principles and Practice of Ophthalmology. Albert DM, Jakobiec FA, Azar DT, Gragounds, editors, 2nd ed. Philadelphia: WB Saunders Company; 2000; 258-65.vo0-1.
9. McGhee Charles NJ, Dean S and Danesh-Meyer H. The locally administered ocular corticosteroids and their benefits and risks. Drug Safety 2002;25(1):33-35.
10. Nussenblatt RB, Whitcup SM. Examination of the patients with uveitis. In: Uveitis Fundamentals and Clinical Practice. 3rd ed. Mosbay;2004; 54-65.
11. DeLoach LJ, Higgins MS, Caplan AB, Stiff JL. The visual analog scale in the immediate postoperative period: the intrasubject variability and the correlation with a numerical scale. Anesth Analg 1998;86:102-06.
12. Schimmer BP, Parker KL. The adrenocorticotrophic hormone-adrenocortical steroids and their synthetic analogs, Inhibition of the synthesis and action of the adrenocortical hormones. In: Goodman and Gillman's The Pharmacological Basis of therapeutics, Brunton LL. editor,11th ed. New Delhi: Mc Graw Hill;2006; 1587-612.
13. Awan MA, Agarwal PK, Watson DG, McGhee Charles NJ, Dutton GN. Penetration of the topical and the subconjunctival corticosteroids into the human aqueous humor and its therapeutic significance. Brit J Ophthalmol 2009;33:708-13.
14. th ed. Brunton LL editor. New Delhi: McGrew Hill; 2006; 671-716.
15. Solomon KD, Cheetham JK, DeGryse R, Brint SF, Rosenthal A. The topical ketorolac tromethamine 0.5% ophthalmic solution in the ocular inflammation after cataract surgeries. Ophthalmology 2001; 108(2):331-37.
16. Miyanaga M, Miyai T, Nejima R, Maruyama Y, Miyata K and Kato S. The effect of the Bromfenac ophthalmic solution on the ocular inflammation following cataract surgeries. Acta Ophthalmol 2009; 87(3):300-05.
17. Solomon KD, Turkalj JW, Whiteside SB, Stewart JA, Apple DJ. Topical 0.5% Ketorolac vs 0.03% Flurbiprofen for the inhibition of miosis during cataract surgeries. Arch Ophthalmol.1997;115:1119-22.
18. Reddy MS, Suneetha N, Thomas RK, Battu RR. Topical diclofenac sodium for the treatment of the postoperative inflammation in cataract surgeries. Indian J Ophthalmol 2000; 48(3):223-26.