Recent advances in quantitative proteomics as a sensitive tool to quantify drug transporters and drug metabolizing enzymes at the human blood-brain barrier;Apport de la protéomique quantitative dans la caractérisation de transporteurs et enzymes modulant le passage des médicaments au travers de la barrière hémato-encéphalique

Biologie Aujourd'hui

Volumn 206, Issue 3, 2012, Pages 177-183

  Jacob, Aude ^a   Declèves, Xavier ^a   Scherrmann, Jean Michel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Blood brain barrier; Enzymes; Neuropharmacology; Transporters

Indexed keywords

CARRIER PROTEIN; CENTRAL NERVOUS SYSTEM AGENTS; CYTOCHROME P450;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CHEMISTRY; ENDOTHELIUM CELL; ENZYMOLOGY; HUMAN; METABOLISM; PHYSIOLOGY; PROTEOMICS;

BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIAL CELLS; HUMANS; MEMBRANE TRANSPORT PROTEINS; PROTEOMICS;

EID: 84870015265     PISSN: 21050678     EISSN: 21050686     Source Type: Journal    
DOI: 10.1051/jbio/2012022     Document Type: Article

References (8)

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8. Shawahna R., Uchida Y., Decl̀eves X., Ohtsuki S., Yousif S., Dauchy S., Jacob A., Chassoux F., Daumas-Duport C., Couraud P.O., Terasaki T., Scherrmann J.M., Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm, 2011, 8, 1332-1341.