Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 10108-10117

  Hu, Guoping ^a   Li, Xi ^a   Zhang, Xuan ^b   Li, Yaozong ^a   Ma, Lei ^a   Yang, Liu Meng ^b   Liu, Guixia ^a   Li, Weihua ^a   Huang, Jin ^a   Shen, Xu ^c   Hu, Lihong ^c   Zheng, Yong Tang ^b   Tang, Yun ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b KUNMING INSTITUTE OF ZOOLOGY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

10 (BENZYLOXY) 2,2,6A,6B,9,9,12A HEPTAMETHYL 1,2,3,4,4A,5,6,6A,6B,7,8,9,10,11,12,12A,12B,13,14B ICOSAHYDROPICENE 4A, CARBOXYLIC ACID; 3 (2 CHLOROPHENYL) 1 (2,4 DIHYDROXYPHENYL)PROP 2 EN 1 ONE; 3 (2 CHLOROPHENYL) 2 [5 (10 HYDROXY 2,2,6A,6B,9,9,12A,12B,13,14B ICOSAHYDROPICEN 4A YL)PENTANAMIDO] PROPANOIC ACID; 3 (2,3 DIHYDROXYPHENYL) 1 (2,4,6 TRIHDYROXYPHENYL)PROP 2 EN 1 ONE; 4 (BENZYLOXY) 2 HYDROXY N (3 NITROBENZYL)BENZAMIDE; ANTIVIRUS AGENT; ENZYME INHIBITOR; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; NATURAL PRODUCT; ROSMARINIC ACID; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; BIOASSAY; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MOLECULAR WEIGHT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTI-HIV AGENTS; BIOLOGICAL ASSAY; CELL DEATH; CHALCONES; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84869988552     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301226a     Document Type: Article

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