Role of predisposition, injury, response and organ failure in the prognosis of patients with acute-on-chronic liver failure: A prospective cohort study

Critical Care

Volumn 16, Issue 6, 2012, Pages

  Jalan, Rajiv ^a   Stadlbauer, Vanessa ^a,b   Sen, Sambit ^a   Cheshire, Lisa ^a   Chang, Yu Mei ^c   Mookerjee, Rajeshwar P ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; TERLIPRESSIN;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; ALBUMIN DIALYSIS; ANTIBIOTIC THERAPY; ARTICLE; ASCITES; ASSISTED VENTILATION; COHORT ANALYSIS; DECOMPENSATED LIVER CIRRHOSIS; DETERIORATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HEMOFILTRATION; HEPATORENAL SYNDROME; HOSPITALIZATION; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; ORGAN FAILURE; PARACENTESIS; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RISK; SODIUM RESTRICTION; ACUTE-ON-CHRONIC LIVER FAILURE; COMPLICATION; DISEASE COURSE; INFECTION; LIVER CIRRHOSIS; MIDDLE AGED; RISK FACTOR; STATISTICAL MODEL; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ACUTE-ON-CHRONIC LIVER FAILURE; DISEASE PROGRESSION; FEMALE; HUMANS; INFECTION; LIVER CIRRHOSIS; LOGISTIC MODELS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84869886476     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11882     Document Type: Article

References (47)

1. WHO Projections of mortality and burden of disease to 2030 2004, Geneva: World Health Organization Press, WHO.
2. Neuberger J, James O. Guidelines for selection of patients for liver transplantation in the era of donor-organ shortage. Lancet 1999, 354:1636-1639.
3. Duseja A, Chawla YK, Dhiman RK, Kumar A, Choudhary N, Taneja S. Non-hepatic insults are common acute precipitants in patients with acute on chronic liver failure (ACLF). Dig Dis Sci 2010, 55:3188-3192.
4. Sarin SK, Kumar A, Almeida JA, Chawla YK, Fan ST, Garg H, de Silva HJ, Hamid SS, Jalan R, Komolmit P, Lau GK, Liu Q, Madan K, Mohamed R, Ning Q, Rahman S, Rastogi A, Riordan SM, Sakhuja P, Samuel D, Shah S, Sharma BC, Sharma P, Takikawa Y, Thapa BR, Wai CT, Yuen MF. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 2009, 3:269-282.
5. Sen S, Williams R, Jalan R. The pathophysiological basis of acute-on-chronic liver failure. Liver 2002, 22(Suppl 2):5-13.
6. Wehler M, Kokoska J, Reulbach U, Hahn EG, Strauss R. Short-term prognosis in critically ill patients with cirrhosis assessed by prognostic scoring systems. Hepatology 2001, 34:255-261.
7. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992, 20:864-874.
8. Child C, Turcotte J. Surgery and portal hypertension 1964, Philadelphia: Saunders.
9. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, D'Amico G, Dickson ER, Kim WR. A model to predict survival in patients with end-stage liver disease. Hepatology 2001, 33:464-470.
10. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
11. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973, 60:646-649.
12. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
13. D'Amico G, Morabito A, Pagliaro L, Marubini E. Survival and prognostic indicators in compensated and decompensated cirrhosis. Dig Dis Sci 1986, 31:468-475.
14. Huo TI, Lin HC, Wu JC, Lee FY, Hou MC, Lee PC, Chang FY, Lee SD. Proposal of a modified Child-Turcotte-Pugh scoring system and comparison with the model for end-stage liver disease for outcome prediction in patients with cirrhosis. Liver Transpl 2006, 12:65-71.
15. Katoonizadeh A, Laleman W, Verslype C, Wilmer A, Maleux G, Roskams T, Nevens F. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut 2010, 59:1561-1569.
16. Goldfarb G, Nouel O, Poynard T, Rueff B. Efficiency of respiratory assistance in cirrhotic patients with liver failure. Intensive Care Med 1983, 9:271-273.
17. Shellman RG, Fulkerson WJ, DeLong E, Piantadosi CA. Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit. Crit Care Med 1988, 16:671-678.
18. Zauner CA, Apsner RC, Kranz A, Kramer L, Madl C, Schneider B, Schneeweiss B, Ratheiser K, Stockenhuber F, Lenz K. Outcome prediction for patients with cirrhosis of the liver in a medical ICU: a comparison of the APACHE scores and liver-specific scoringsystems. Intensive Care Med 1996, 22:559-563.
19. Zimmerman JE, Wagner DP, Seneff MG, Becker RB, Sun X, Knaus WA. Intensive care unit admissions with cirrhosis: risk-stratifying patient groups and predicting individual survival. Hepatology 1996, 23:1393-1401.
20. Lee KC, Chiang AA. The outcome of terminal liver cirrhosis patients requiring mechanical ventilation. Zhonghua Yi Xue Za Zhi (Taipei) 1997, 59:88-94.
21. Singh N, Gayowski T, Wagener MM, Marino IR. Outcome of patients with cirrhosis requiring intensive care unit support: prospective assessment of predictors of mortality. J Gastroenterol 1998, 33:73-79.
22. Kress JP, Rubin A, Pohlman AS, Hall JB. Outcomes of critically ill patients denied consideration for liver transplantation. Am J Respir Crit Care Med 2000, 162:418-423.
23. Aggarwal A, Ong JP, Younossi ZM, Nelson DR, Hoffman-Hogg L, Arroliga AC. Predictors of mortality and resource utilization in cirrhotic patients admitted to the medical ICU. Chest 2001, 119:1489-1497.
24. Tsai MH, Chen YC, Ho YP, Fang JT, Lien JM, Chiu CT, Liu NJ, Chen PC. Organ system failure scoring system can predict hospital mortality in critically ill cirrhotic patients. J Clin Gastroenterol 2003, 37:251-257.
25. Tsai MH, Peng YS, Lien JM, Weng HH, Ho YP, Yang C, Chu YY, Chen YC, Fang JT, Chiu CT, Chen PC. Multiple organ system failure in critically ill cirrhotic patients. A comparison of two multiple organ dysfunction/failure scoring systems. Digestion 2004, 69:190-200.
26. Chen YC, Tsai MH, Ho YP, Hsu CW, Lin HH, Fang JT, Huang CC, Chen PC. Comparison of the severity of illness scoring systems for critically ill cirrhotic patients with renal failure. Clin Nephrol 2004, 61:111-118.
27. Chen YC, Tsai MH, Hsu CW, Ho YP, Lien JM, Chang MY, Fang JT, Huang CC, Chen PC. Role of serum creatinine and prognostic scoring systems in assessing hospital mortality in critically ill cirrhotic patients with upper gastrointestinal bleeding. J Nephrol 2003, 16:558-565.
28. Ho YP, Chen YC, Yang C, Lien JM, Chu YY, Fang JT, Chiu CT, Chen PC, Tsai MH. Outcome prediction for critically ill cirrhotic patients: a comparison of APACHE II and Child-Pugh scoring systems. J Intensive Care Med 2004, 19:105-110.
29. Gildea TR, Cook WC, Nelson DR, Aggarwal A, Carey W, Younossi ZM, Arroliga AC. Predictors of long-term mortality in patients with cirrhosis of the liver admitted to a medical ICU. Chest 2004, 126:1598-1603.
30. Cholongitas E, Senzolo M, Patch D, Kwong K, Nikolopoulou V, Leandro G, Shaw S, Burroughs AK. Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit. Aliment Pharmacol Ther 2006, 23:883-893.
31. Cholongitas E, Senzolo M, Patch D, Shaw S, O'Beirne J, Burroughs AK. Cirrhotics admitted to intensive care unit: the impact of acute renal failure on mortality. Eur J Gastroenterol Hepatol 2009, 21:744-750.
32. Afessa B, Kubilis PS. Upper gastrointestinal bleeding in patients with hepatic cirrhosis: clinical course and mortality prediction. Am J Gastroenterol 2000, 95:484-489.
33. Rabe C, Schmitz V, Paashaus M, Musch A, Zickermann H, Dumoulin FL, Sauerbruch T, Caselmann WH. Does intubation really equal death in cirrhotic patients? Factors influencing outcome in patients with liver cirrhosis requiring mechanical ventilation. Intensive Care Med 2004, 30:1564-1571.
34. Tu KH, Jenq CC, Tsai MH, Hsu HH, Chang MY, Tian YC, Hung CC, Fang JT, Yang CW, Chen YC. Outcome scoring systems for short-term prognosis in critically ill cirrhotic patients. Shock 2011, 36:445-450.
35. Levesque E, Hoti E, Azoulay D, Ichai P, Habouchi H, Castaing D, Samuel D, Saliba F. Prospective evaluation of the prognostic scores for cirrhotic patients admitted to an intensive care unit. J Hepatol 2012, 56:95-102.
36. Fernandez J, Navasa M, Gomez J, Colmenero J, Vila J, Arroyo V, Rodes J. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology 2002, 35:140-148.
37. Leber B, Mayrhauser U, Rybczynski M, Stadlbauer V. Innate immune dysfunction in acute and chronic liver disease. Wien Klin Wochenschr 2009, 121:732-744.
38. Arabi Y, Ahmed QA, Haddad S, Aljumah A, Al-Shimemeri A. Outcome predictors of cirrhosis patients admitted to the intensive care unit. Eur J Gastroenterol Hepatol 2004, 16:333-339.
39. Borzio M, Salerno F, Piantoni L, Cazzaniga M, Angeli P, Bissoli F, Boccia S, Colloredo-Mels G, Corigliano P, Fornaciari G, Marenco G, Pistara R, Salvagnini M, Sangiovanni A. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study. Dig Liver Dis 2001, 33:41-48.
40. Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut 2005, 54:718-725.
41. Thabut D, Massard J, Gangloff A, Carbonell N, Francoz C, Nguyen-Khac E, Duhamel C, Lebrec D, Poynard T, Moreau R. Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure. Hepatology 2007, 46:1872-1882.
42. Cazzaniga M, Dionigi E, Gobbo G, Fioretti A, Monti V, Salerno F. The systemic inflammatory response syndrome in cirrhotic patients: relationship with their in-hospital outcome. J Hepatol 2009, 51:475-482.
43. Shawcross DL, Davies NA, Williams R, Jalan R. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 2004, 40:247-254.
44. Wright G, Davies NA, Shawcross DL, Hodges SJ, Zwingmann C, Brooks HF, Mani AR, Harry D, Stadlbauer V, Zou Z, Williams R, Davies C, Moore KP, Jalan R. Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology 2007, 45:1517-1526.
45. Wasmuth HE, Kunz D, Yagmur E, Timmer-Stranghoner A, Vidacek D, Siewert E, Bach J, Geier A, Purucker EA, Gressner AM, Matern S, Lammert F. Patients with acute on chronic liver failure display "sepsis-like" immune paralysis. J Hepatol 2005, 42:195-201.
46. Berres ML, Schnyder B, Yagmur E, Inglis B, Stanzel S, Tischendorf JJ, Koch A, Winograd R, Trautwein C, Wasmuth HE. Longitudinal monocyte human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis. Liver Int 2009, 29:536-543.
47. Jacobsson G, Nasic S. Long-term outcome of invasive Staphylococcus aureus infections. Scand J Infect Dis 2012, 44:350-354.