Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender®, Bayer) and praziquantel and pyrantel oral tablets (Drontal® for Cats) against experimental Ancylostoma ceylanicum infections in cats

Veterinary Parasitology

Volumn 191, Issue 1-2, 2013, Pages 172-176

  Taweethavonsawat, Piyanan ^a   Chungpivat, Sudchit ^a   Watanapongchati, Supoj ^b   Traub, Rebecca J ^c   Schaper, Roland ^d  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b Bayer Thai ^*  (Thailand)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d BAYER AG   (Germany)

Author keywords

Ancylostoma; Cat; Ceylanicum; Drontal; Efficacy; Emodepside; Hookworm; Profender; Pyrantel

Indexed keywords

ANTHELMINTIC AGENT; DRONTAL; EMODEPSIDE PLUS PRAZIQUANTEL; PRAZIQUANTEL PLUS PYRANTEL; UNCLASSIFIED DRUG;

ANCYLOSTOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE TRANSMISSION; DOSE RESPONSE; DRUG EFFICACY; EXPERIMENTAL INFECTION; FECES ANALYSIS; KITTEN; LARVAL STAGE; NONHUMAN; PARASITE IDENTIFICATION; RECOMMENDED DRUG DOSE;

ANCYLOSTOMIASIS; ANIMALS; ANTINEMATODAL AGENTS; CAT DISEASES; CATS; DEPSIPEPTIDES; DRUG COMBINATIONS; FECES; PRAZIQUANTEL; PYRANTEL; RANDOM ALLOCATION; TREATMENT OUTCOME;

ANCYLOSTOMA; ANCYLOSTOMA CEYLANICUM; ANCYLOSTOMATOIDEA; CANIS FAMILIARIS;

EID: 84869868344     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2012.08.024     Document Type: Article

References (32)

1. Altreuther G., Borgsteede F.H., Buch J., Charles S.D., Cruthers L., Epe C., Young D.R., Krieger K.J. Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats. Parasitol. Res. 2005, 97(Suppl. 1):S51-S57.
2. Altreuther G., Buch J., Charles S.D., Davis W.L., Krieger K.J., Radeloff I. Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats. Parasitol. Res. 2005, 97(Suppl. 1):S58-S64.
3. Anten J.F., Zuidema P.J. Hookworm infection in Dutch servicemen returning from West New Guinea. Trop. Geogr. Med. 1964, 64:216-224.
4. Baker M.K., Lange L., Verster A., van der Plaat S. A survey of helminths in domestic cats in the Pretoria area of Transvaal Republic of South Africa. Part 1: the prevalence and comparison of burdens of helminths in adult and juvenile cats. J. S. Afr. Vet. Assoc. 1989, 60:139-142.
5. Carroll S.M., Grove D.I. Parasitological, hematologic, and immunologic responses in acute and chronic infections of dogs with Ancylostoma ceylanicum: a model of human hookworm infection. J. Infect. Dis. 1984, 150:284-294.
6. Conlan J.V., Khamlome B., Vongxay K., Elliot A., Pallant L., Sripa B., Blacksell S.D., Fenwick S., Thompson R.C. Soil-transmitted helminthiasis in laos: a community-wide cross-sectional study of humans and dogs in a mass drug administration environment. Am. J. Trop. Med. Hyg. 2012, 86:624-634.
7. Dissanaike A.S. On some helminths of dogs in Colombo and their bearing on human infections, with a description of a new trematode Heterophysopsis yehi sp. nov (Heterphyidae). Ceylon J. Med. Sci. 1961, 10:1-12.
8. Haydon G., Bearup A. Correspondence: Ancylostoma braziliense and Ancylostoma ceylanicum. Trans. R. Soc. Trop. Med. Hyg. 1963, 57:76.
9. Jiraanankul V., Aphijirawat W., Mungthin M., Khositnithikul R., Rangsin R., Traub R.J., Piyaraj P., Naaglor T., Taamasri P., Leelayoova S. Incidence and risk factors of hookworm infection in a rural community of central Thailand. Am. J. Trop. Med. Hyg. 2011, 84:594-598.
10. Lachin J.M. Some large-sample distribution-free estimators and tests for multivariate partially incomplete data from two populations. Stat. Med. 1992, 11:1151-1170.
11. Margono S.S., Koesharjono C., Kosin E. Hookworm in dogs and cats in the area of Jakarta. Trop. Geogr. Med. 1979, 31:257-261.
12. Ngui R., Lim Y.A., Traub R., Mahmud R., Mistam M.S. Epidemiological and genetic data supporting the transmission of Ancylostoma ceylanicum among human and domestic animals. PLoS Negl. Trop. Dis. 2012, 6:e1522.
13. Palmer C.S., Traub R.J., Robertson I.D., Hobbs R.P., Elliot A., While L., Rees R., Thompson R.C. The veterinary and public health significance of hookworm in dogs and cats in Australia and the status of A. ceylanicum. Vet. Parasitol. 2007, 145:304-313.
14. Pratt P.W. Laboratory Procedures for Veterinary Technicians 1997, Mosby, St. Louis. 3rd ed.
15. Rep B.H., Heinemann D.W. Changes in hookworm distribution in Surinam. Trop. Geogr. Med. 1976, 28:104-110.
16. Sato M., Sanguankiat S., Yoonuan T., Pongvongsa T., Keomoungkhoun M., Phimmayoi I., Boupa B., Moji K., Waikagul J. Copro-molecular identification of infections with hookworm eggs in rural Lao PDR. Trans. R. Soc. Trop. Med. Hyg. 2010, 104:617-622.
17. Schaper R., Altreuther G., Hopkins T. Efficacy of emodepside plus praziquantel topical solution against immature stages of nematodes (Ancylostoma sp. and Toxocara sp.) in cats. Parasitol. Res. 2007, 101:63-68.
18. Scholz T., Uhlirova M., Ditrich O. Helminth parasites of cats from the Vientiane province, Laos, as indicators of the occurrence of causative agents of human parasitoses. Parasite (Paris, France) 2003, 10:343-350.
19. Schuster R.K., Thomas K., Sivakumar S., O'Donovan D. The parasite fauna of stray domestic cats (Felis catus) in Dubai, United Arab Emirates. Parasitol. Res. 2009, 105:125-134.
20. Setasuban P., Vajrasthira S., Muennoo C. Prevalence and zoonotic potential of Ancylostoma ceylanicum in cats in Thailand. Southeast Asian J. Trop. Med. Public Health 1976, 7:534-539.
21. Taweethavonsawat P., Chungpivat S., Satranarakun P., Traub R.J., Schaper R. Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs. Parasitol. Res. 2009, 106:533-537.
22. ® Multi, Bayer Animal Health) against Ancylostoma ceylanicum in cats. Vet. Parasitol. 2012, 10.1016/j. vetpar.2012.05.008.
23. Thall P.F., Lachin J.M. Analysis of recurrent events: nonparametric methods for random interval count data. J. Am. Stat. Assoc. 1988, 83:339-347.
24. Thompson R.C., Conlan J.V. Emerging issues and parasite zoonoses in the SE Asian and Australasian region. Vet. Parasitol. 2011, 181:69-73.
25. Traub R.J., Hobbs R.P., Adams P.J., Behnke J.M., Harris P.D., Thompson R.C. A case of mistaken identity-reappraisal of the species of canid and felid hookworms (Ancylostoma) present in Australia and India. Parasitology 2007, 134:113-119.
26. Traub R.J., Inpankaew T., Sutthikornchai C., Sukthana Y., Thompson R.C. PCR-based coprodiagnostic tools reveal dogs as reservoirs of zoonotic ancylostomiasis caused by Ancylostoma ceylanicum in temple communities in Bangkok. Vet. Parasitol. 2008, 155:67-73.
27. Traub R.J., Robertson I.D., Irwin P., Mencke N., Thompson R.C. Application of a species-specific PCR-RFLP to identify Ancylostoma eggs directly from canine faeces. Vet. Parasitol. 2004, 123:245-255.
28. Traversa D., Milillo P., Di Cesare A., Lohr B., Iorio R., Pampurini F., Schaper R., Bartolini R., Heine J. Efficacy and safety of emodepside 2.1%/praziquantel 8.6% spot-on formulation in the treatment of feline aelurostrongylosis. Parasitol. Res. 2009, 105(Suppl. 1):S83-S89.
29. VICH Guideline: 19, 2001. Efficacy for Anthelmintics: Specific Requirements for Canines (Veterinary International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products).
30. Wei L.J., Lachin J.M. Two-sample asymptotically distribution-free tests for incomplete multivariate observations. J. Am. Stat. Assoc. 1984, 79:653-661.
31. Wijers D.J., Smit A.M. Early symptoms after experimental infection of man with Ancylostoma braziliense var. ceylanicum. Trop. Geogr. Med. 1966, 18:48-52.
32. Yoshida Y., Okamoto K., Chiu J.K. Ancylostoma ceylanicum infection in dogs, cats, and man in Taiwan. Am. J. Trop. Med. Hyg. 1968, 17:378-381.