A pharmacokinetic study of a topical anesthetic (EMLA®) in mouse soft tissue laceration

Dental Traumatology

Volumn 28, Issue 6, 2012, Pages 483-487

  Al Musawi, Alaa ^a   Matar, Kamal ^a   Kombian, Samuel B ^a   Andersson, Lars ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Anesthesia; Laceration; Mouse; Pharmacokinetics; Soft tissue; Wound

Indexed keywords

EMLA; LIDOCAINE; LOCAL ANESTHETIC AGENT; PRILOCAINE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BAGG ALBINO MOUSE; BLOOD; COMPARATIVE STUDY; DRUG EFFECT; LACERATION; LIQUID CHROMATOGRAPHY; METABOLISM; MOUSE; SKIN; SOFT TISSUE INJURY; TANDEM MASS SPECTROMETRY;

ANESTHETICS, LOCAL; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; LACERATIONS; LIDOCAINE; MICE; MICE, INBRED BALB C; PRILOCAINE; SKIN; SOFT TISSUE INJURIES; TANDEM MASS SPECTROMETRY;

EID: 84869867996     PISSN: 16004469     EISSN: 16009657     Source Type: Journal    
DOI: 10.1111/j.1600-9657.2012.01172.x     Document Type: Article

References (24)

1. Petersson EE, Andersson L, Sörensen S. Traumatic oral vs non-oral injuries. An epidemioilogical study during one year in a Swedish county. Swed Dent J 1997;21:55-68.
2. Abu Al-Melh M, Andersson L, Behbehani E. Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine. J Clin Dent 2005;16:53-6.
3. Al-Melh MA, Andersson L. Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:e16-20.
4. Manner T, Kanto J, Iisalo E, Lindberg R, Viinamaki O, Scheinin M. Reduction of pain at venous cannulation in children with a eutectic mixture of lidocaine and prilocaine (EMLA cream); comparison with placebo and no local premedication. Acta Anaesthesiol Scand 1987;31:735-9.
5. Hopkins CS, Buckley CJ, Bush GH. Pain-free injection in infants: use of a lignocaine-prilocaine cream to prevent pain at intravenous induction of general anaesthesia in 1-5 years old children. Anaesthesia 1988;43:198-201.
6. Halperin DL, Koren G, Attias D, Pellegrini E, Greenberg ML, Wyss M. Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children. Pediatrics 1989;84:281-4.
7. Al-Melh MA, Andersson L. Reducing pain from palatal needle stick by topical anesthetics: a comparative study between two lidocaine/prilocaine substances. J Clin Dent 2008;19:43-7.
8. Joki-Erkkilä VP, Penttilä M, Kääriäinen J, Rautiainen M. Local anesthesia with EMLA cream for maxillary sinus puncture. Ann Otol Rhinol Laryngol 2002;111:80-2.
9. Zilbert A. Topical anesthesia for minor gynecological procedures: a review. Obstet Gynecol Surv 2002;57:171-8.
10. McMillan AS, Walshaw D, Meechan JG. The efficacy of EMLA and 5% lignocaine gel for anaesthesia of human gingival mucosa. Br J Oral Maxillofac Surg 2000;38:58-61.
11. Jeffcoat MK, Geurs NC, Magnusson I, MacNeill SR, Mickels N, Roberts F et al. Intrapocket anesthesia for scaling and root planing: results of a double-blind multicenter trial using lidocaine prilocaine dental gel. J Periodontol 2001;72:895-900.
12. Munshi AK, Hegde AM, Latha R. Use of EMLA: is it an injection free alternative? J Clin Pediatr Dent 2001;25:215-9.
13. Friskopp J, Nilsson M, Isacsson G. The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing. J Clin Periodontol 2001;28:453-8.
14. Friskopp J, Huledal G. Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis. J Clin Periodontol 2001;28:425-9.
15. Al-Musawi A, Andersson L. Use of topical anesthetic EMLA cream as the only local anesthetic to re-approximate a traumatic facial laceration. Dent Traumatol 2010;26:292-3.
16. Al-Asfour A, Al-Melh M, Andersson L, Joseph B. Healing pattern of experimental soft tissue lacerations after application of novel topical anesthetic agents - an experimental study in rabbits. Dent Traumatol 2008;24:27-31.
17. Nilsson A, Engberg G, Henneberg S, Danielson K, DeVerdier CH. Inverse relationship between age-dependent erythrocyte activity of methaemoglobin reductase and prilocaine-induced methaemoglobinaemia during infancy. Br J Anaesth 1990;64:72-6.
18. Conroy JM, Baker JD, Martin WJ, Bailey MK, Dorman BH. Acquired methemoglobinemia from multiple oxidants. South Med J 1993;86:1156-9.
19. Hjelt K, Lund JT, Scherling B, Bendixen S, Lundstrom K, Stovring S, et al. Methaemoglobinaemia among neonates in a neonatal intensive care unit. Acta Paediatr 1995;84:365-70.
20. Tse S, Barrington K, Byrne P. Methemoglobinemia associated with prilocaine use in neonatal circumcision. Am J Perinatol 1995;12:331-2.
21. Jakobson B, Nilsson A. Methemoglobinemia associated with a prilocaine-lidocaine cream and trimetoprim-sulphamethoxazole. A case report. Acta Anaesthesiol Scand 1985;29:453-5.
22. Gibaldi M, Perrier D. Pharmacokinetics, 2nd edn. New York: Marcel Dekker; 1982:37-43.
23. Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 1996;67:1103-13.
24. Offenbacher S, Beck JD, Lieff S, Slade G. Role of periodontitis in systemic health: spontaneous preterm birth. J Dent Educ 1998;62:852-8.