Fab-arm exchange is a misnomer

mAbs

Volumn 4, Issue 6, 2012, Pages 635-

  Pandey, Janardan P ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN G4 ANTIBODY; LEUCINE; LYSINE; UNCLASSIFIED DRUG; VALINE;

GENE LOCUS; HETEROZYGOTE; HUMAN; LETTER;

HUMANS; IMMUNOGLOBULIN ALLOTYPES; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOTHERAPY; INFLAMMATION;

EID: 84869855209     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.21613     Document Type: Letter

References (4)

1. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012; 366:539-51; PMID:22316447; http://dx.doi.org/10.1056/NEJMra1104650
2. van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martínez-Martínez P, Vermeulen E, et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 2007; 317:1554-7; PMID:17872445; http://dx.doi.org/10.1126/science.1144603
3. Brusco A, Saviozzi S, Cinque F, DeMarchi M, Boccazzi C, de Lange G, et al. Molecular characterization of immunoglobulin G4 gene isoallotypes. Eur J Immunogenet 1998; 25:349-55; PMID:9805657; http://dx.doi.org/10.1046/j.1365- 2370.1998.00113.x
4. Labrijn AF, Rispens T, Meesters J, Rose RJ, den Bleker TH, Loverix SJ, et al. Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength. J Immunol 2011; 187:3238-46; PMID:21841137; http://dx.doi.org/10.4049/jimmunol.1003336