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Volumn 10, Issue 6, 2012, Pages 429-435

A new ent- kaurenoid derivative CPUK02 notably inhibits tumor growth through induction of apoptosis

Author keywords

Anticancer; Apoptosis; Ent Kaurene; In vitro and in vivo evaluation; Semi synthetic derivative

Indexed keywords

15 OXOSTEVIOL BENZYL ESTER; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; CPUK 02; FLUOROURACIL; UNCLASSIFIED DRUG;

EID: 84869797431     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(12)60083-1     Document Type: Article
Times cited : (4)

References (22)
  • 1
    • 27844534829 scopus 로고    scopus 로고
    • Bcl-2 Up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis [J]
    • Huang J, Wu LJ, Tashiro S, et al. Bcl-2 Up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis [J]. Biol Pharm Bull 2005, 28(11):2068-2074.
    • (2005) Biol Pharm Bull , vol.28 , Issue.11 , pp. 2068-2074
    • Huang, J.1    Wu, L.J.2    Tashiro, S.3
  • 2
    • 17144362778 scopus 로고    scopus 로고
    • Novel cytotoxic kaurane-type diterpenoids from the New Zealand liverwort, Jungermannia species [J]
    • Nagashima F, Kondoh M, Fujii, et al. Novel cytotoxic kaurane-type diterpenoids from the New Zealand liverwort, Jungermannia species [J]. Tetrahedron 2005, 61:4531-4544.
    • (2005) Tetrahedron , vol.61 , pp. 4531-4544
    • Nagashima, F.1    Kondoh, M.2    Fujii et, al.3
  • 3
    • 85193623561 scopus 로고    scopus 로고
    • The mechanism of proliferative inhibition of Acanthopanax senticosus and oridonin for Eca-109 cells [J]
    • Zhang S, Wang LX, Fan QX, et al. The mechanism of proliferative inhibition of Acanthopanax senticosus and oridonin for Eca-109 cells [J]. J Basic Clin Oncol 2007, 20(3):226-229.
    • (2007) J Basic Clin Oncol , vol.20 , Issue.3 , pp. 226-229
    • Zhang, S.1    Wang, L.X.2    Fan, Q.X.3
  • 4
    • 33746220391 scopus 로고    scopus 로고
    • Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys [J]
    • Li X, Xiao W, Pu J, et al. Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys [J]. Phytochemistry 2006, 67:1336-1340.
    • (2006) Phytochemistry , vol.67 , pp. 1336-1340
    • Li, X.1    Xiao, W.2    Pu, J.3
  • 5
    • 0032868426 scopus 로고    scopus 로고
    • Study on the diterpenoid constituents and anticancer action of Pteris semipinnata [J]
    • Xiao Z, Jinhua L, Chengwei H, et al. Study on the diterpenoid constituents and anticancer action of Pteris semipinnata [J]. Chin Pharm J 1999, 34(8):512-514.
    • (1999) Chin Pharm J , vol.34 , Issue.8 , pp. 512-514
    • Xiao, Z.1    Jinhua, L.2    Chengwei, H.3
  • 6
    • 76749169538 scopus 로고    scopus 로고
    • Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways [J]
    • Zhang YW, Jiang XX, Chen QS, et al. Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways [J]. Exp Hematol 2010, 38:191-201.
    • (2010) Exp Hematol , vol.38 , pp. 191-201
    • Zhang, Y.W.1    Jiang, X.X.2    Chen, Q.S.3
  • 7
    • 0017172723 scopus 로고
    • The antitumor and antibacterial activity of the Isodon diterpenoids [J]
    • Fujita E, Nagao Y, Kaneko K, et al. The antitumor and antibacterial activity of the Isodon diterpenoids [J]. Chem Pharm Bull 1976, 24(9):2118-2127.
    • (1976) Chem Pharm Bull , vol.24 , Issue.9 , pp. 2118-2127
    • Fujita, E.1    Nagao, Y.2    Kaneko, K.3
  • 8
    • 0020056251 scopus 로고
    • Antitumor activity of Rabdosia and Teucrium diterpenoids against P388 lymphocytic leukemia in mice [J]
    • Nagao Y, Ito N, Kohno T, et al. Antitumor activity of Rabdosia and Teucrium diterpenoids against P388 lymphocytic leukemia in mice [J]. Chem Pharm Bull 1982, 30(2):727-729.
    • (1982) Chem Pharm Bull , vol.30 , Issue.2 , pp. 727-729
    • Nagao, Y.1    Ito, N.2    Kohno, T.3
  • 9
    • 0019832160 scopus 로고
    • Antitumor activity of acylated oridonin [J]
    • Fujita E, Nagao Y, Kohno T, et al. Antitumor activity of acylated oridonin [J]. Chem Pharm Bull 1981, 29(11):3208-3213.
    • (1981) Chem Pharm Bull , vol.29 , Issue.11 , pp. 3208-3213
    • Fujita, E.1    Nagao, Y.2    Kohno, T.3
  • 11
    • 59749101408 scopus 로고    scopus 로고
    • Advances in research on cytotoxic activity of ent-kaurane diterpenoids [J]
    • Zhang DY, Li ZY, Shi LY, et al. Advances in research on cytotoxic activity of ent-kaurane diterpenoids [J]. Chin J Org Chem 2008, 28(11):1911-1917.
    • (2008) Chin J Org Chem , vol.28 , Issue.11 , pp. 1911-1917
    • Zhang, D.Y.1    Li, Z.Y.2    Shi, L.Y.3
  • 12
    • 68049087909 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW264.7 murine macrophages [J]
    • Aquila S, Weng ZY, Zeng YQ, et al. Inhibition of NF-kappaB activation and iNOS induction by ent-kaurane diterpenoids in LPS-stimulated RAW264.7 murine macrophages [J]. J Nat Prod 2009, 7:1269-1272.
    • (2009) J Nat Prod , vol.7 , pp. 1269-1272
    • Aquila, S.1    Weng, Z.Y.2    Zeng, Y.Q.3
  • 13
    • 85193570166 scopus 로고    scopus 로고
    • Patent, CN: 200810242967 [P]. 2008-12-31. (Publication No. CN: 101768075A
    • 2010.07.07).
    • Zhang DY, Wu XM, Tang Y. Patent, CN: 200810242967 [P]. 2008-12-31. (Publication No. CN: 101768075A, 2010.07.07).
    • Zhang, D.Y.1    Wu, X.M.2    Tang, Y.3
  • 14
    • 85193568967 scopus 로고    scopus 로고
    • Patent, CN: 200910234685 [P]. 2009-11-27. (Publication No. CN: 102079700A, 2011.06.01).
    • Zhang DY, Wu XM, Li J, et al. Patent, CN: 200910234685 [P]. 2009-11-27. (Publication No. CN: 102079700A, 2011.06.01).
    • Zhang, D.Y.1    Wu, X.M.2    Li, J.3
  • 15
    • 85193593035 scopus 로고    scopus 로고
    • Patent, CN: 201110056672 [P]. 2011-03-10.
    • Zhang DY, Li J, Li Y, et al. Patent, CN: 201110056672 [P]. 2011-03-10.
    • Zhang, D.Y.1    Li, J.2    Li, Y.3
  • 16
    • 78650516447 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents [J]
    • Li J, Zhang DY, Wu XM Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents [J]. Bioorg Med Chem Lett 2011, 21:130-132.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 130-132
    • Li, J.1    Zhang, D.Y.2    Wu, X.M.3
  • 17
    • 22544444405 scopus 로고    scopus 로고
    • Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture [J]
    • Song TY, Hsu SL, Yen GC, et al. Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture [J]. J Ethnopharmacol 2005, 100:158-167.
    • (2005) J Ethnopharmacol , vol.100 , pp. 158-167
    • Song, T.Y.1    Hsu, S.L.2    Yen, G.C.3
  • 18
    • 0032885388 scopus 로고    scopus 로고
    • Mammalian caspases: structure, activation, substrates, and functions during apoptosis [J]
    • Earnshaw WC, Martins L Mammalian caspases: structure, activation, substrates, and functions during apoptosis [J]. Ann Rev Biochem 1999, 68:383-424.
    • (1999) Ann Rev Biochem , vol.68 , pp. 383-424
    • Earnshaw, W.C.1    Martins, L.2
  • 19
    • 0036931366 scopus 로고    scopus 로고
    • Caspases: keys in the ignition of cell death [J]
    • Denault JB, Salvesen GS Caspases: keys in the ignition of cell death [J]. Chem Rev 2002, 102(12):4489-4500.
    • (2002) Chem Rev , vol.102 , Issue.12 , pp. 4489-4500
    • Denault, J.B.1    Salvesen, G.S.2
  • 20
    • 0036195503 scopus 로고    scopus 로고
    • Apoptosome: the seven-spoked death machine [J]
    • Salvesen GS, Renatus M Apoptosome: the seven-spoked death machine [J]. Dev Cell 2002, 2(3):256-257.
    • (2002) Dev Cell , vol.2 , Issue.3 , pp. 256-257
    • Salvesen, G.S.1    Renatus, M.2
  • 21
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes hemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells [J]
    • Vaux DL, Cory S, Adams, et al. Bcl-2 gene promotes hemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells [J]. Nature 1988, 335(6189):440-442.
    • (1988) Nature , vol.335 , Issue.6189 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams et, al.3
  • 22
    • 0032409781 scopus 로고    scopus 로고
    • Bcl-2 family proteins [J]
    • Reed JC Bcl-2 family proteins [J]. Oncogene 1998, 17(25):3225-3236.
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3225-3236
    • Reed, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.