Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype

Cancer Genetics

Volumn 205, Issue 9, 2012, Pages 425-431

  Kristensen, Dina G ^a   Mlynarska, Olga ^a   Nielsen, John E ^a   Jacobsen, Grete K ^a   Rajpert De Meyts, Ewa ^a   Almstrup, Kristian ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Chromatin; Epigenetics; Gene expression; Germ cell neoplasms; Spermatocytic seminoma

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; DNA METHYLTRANSFERASE 3L; HISTONE H2AZ; HISTONE H3; UNCLASSIFIED DRUG;

ARTICLE; CELL SIZE; CHROMATIN; CONTROLLED STUDY; DNA METHYLATION; DNA MODIFICATION; EPIGENETICS; GENETIC HETEROGENEITY; GENOMIC INSTABILITY; HISTONE MODIFICATION; IMMUNOHISTOCHEMISTRY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; SPERMATOGONIUM; TESTICULAR SPERMATOCYTIC SEMINOMA;

CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PHENOTYPE; SEMINOMA; TESTICULAR NEOPLASMS; TESTIS;

EID: 84869761119     PISSN: 22107762     EISSN: 22107770     Source Type: Journal    
DOI: 10.1016/j.cancergen.2012.05.003     Document Type: Article

References (22)

1. Ulbright T., Amin M., Young R. Atlas of tumor pathology. Tumors of the testis, adnexa, spermatic cord, and scrotum 1999, Armed Forces Institute of Pathology, Washington DC.
2. Masson P. Study of the seminoma. Rev Can Biol 1946, 5:361-387.
3. Krag Jacobsen G., Barlebo H., Olsen J., et al. Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. Acta Radiol Oncol 1984, 23:239-247.
4. Chung P.W., Bayley A.J., Sweet J., et al. Spermatocytic seminoma: a review. Eur Urol 2004, 45:495-498.
5. Carriere P., Baade P., Fritschi L. Population based incidence and age distribution of spermatocytic seminoma. J Urol 2007, 178:125-128.
6. Talerman A. Spermatocytic seminoma: clinicopathological study of 22 cases. Cancer 1980, 45:2169-2176.
7. Burke A.P., Mostofi F.K. Spermatocytic seminoma: a clinicopathololgic study of 79 cases. J Urol Pathol 1993, 1:21-32.
8. Kraggerud S.M., Berner A., Bryne M., et al. Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. APMIS 1999, 107:297-302.
9. Looijenga L., Hersmus R., Gillis A., et al. Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Res 2006, 66:290-302.
10. Lim J., Goriely A., Turner G.D., et al. OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. J Pathol 2011, 224:473-483.
11. Rajpert-De Meyts E., Jacobsen G., Bartkova J., et al. The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. Histopathology 2003, 42:217-226.
12. Stoop H., van Gurp R., de Krijger R., et al. Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. Lab Invest 2001, 81:919-928.
13. Goriely A., Hansen R.M., Taylor I.B., et al. Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet 2009, 41:1247-1252.
14. Rajpert-De Meyts E., Bartkova J., Samson M., et al. The emerging phenotype of the testicular carcinoma in situ germ cell. APMIS 2003, 111:267-278. discussion 278-269.
15. Almstrup K., Nielsen J.E., Mlynarska O., et al. Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells. Br J Cancer 2010, 103:1269-1276.
16. Goossens E., Bilgec T., Van Saen D., et al. Mouse germ cells go through typical epigenetic modifications after intratesticular tissue grafting. Hum Reprod 2011, 26:3388-3400.
17. Almstrup K., Hoei-Hansen C., Nielsen J., et al. Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours. Br J Cancer 2005, 92:1934-1941.
18. Marques C.J., Joao Pinho M., Carvalho F., et al. DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stages. Epigenetics 2011, 6:1354-1361.
19. del Mazo J., Prantera G., Torres M., et al. DNA methylation changes during mouse spermatogenesis. Chromosome Res 1994, 2:147-152.
20. Netto G., Nakai Y., Nakayama M., et al. Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. Mod Pathol 2008, 21:1337-1344.
21. Elsheikh S.E., Green A.R., Rakha E.A., et al. Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer Res 2009, 69:3802-3809.
22. Rodriguez J., Frigola J., Vendrell E., et al. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res 2006, 66:8462-9468.