Specificity and sensitivity of INI-1 labeling in epithelioid sarcoma: LOSS of INI1 expression as a frequent immunohistochemical event in synovial sarcoma

Polish Journal of Pathology

Volumn 63, Issue 3, 2012, Pages 179-183

  Mularz, Katarzyna ^a   Harazin Lechowska, Agnieszka ^a   Ambicka, Aleksandra ^a   Kruczak, Anna ^a   Rozmus Pietoń, Magdalena ^a   Marchińska Osika, Urszula ^a   Światkiewicz, Iwona ^a   Król, Marta ^a   Pabis, Dariusz ^a   Januś, Grzegorz ^a   Ryś, Janusz ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

Epithelioid sarcoma; Immunohistochemistry; INI 1 antigen; Synovial sarcoma

Indexed keywords

ANTIBODY; DIAGNOSTIC AGENT; DNA BINDING PROTEIN; NONHISTONE PROTEIN; SMARCB1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER;

ARTICLE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; SARCOMA; SENSITIVITY AND SPECIFICITY; SOFT TISSUE TUMOR;

ANTIBODIES; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; SARCOMA; SENSITIVITY AND SPECIFICITY; SOFT TISSUE NEOPLASMS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84869761028     PISSN: 12339687     EISSN: None     Source Type: Journal    
DOI: 10.5114/PJP.2012.31502     Document Type: Article

References (11)

1. Modena P, Lualdi E, Facchinetti F, et al. SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res 2005; 65: 4012-4019.
2. Cheng SW, Davies KP, Yung E, et al. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Nat Genet 1999; 22: 102-105.
3. Kalpana GV, Marmon S, WangW, et al. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science 1994; 266: 2002-2006.
4. Wu DY, Tkachuck DC, Roberson RS, et al. The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity. J Biol Chem 2002; 277: 27706-27715.
5. Hollmann TJ, Hornick JL. INI1-deficient tumors: diagnostic features and molecular genetics. Am J Surg Pathol 2011; 35: e47-63.
6. Chbani L, Guillou L, Terrier P, et al. Epithelioid sarcoma: a clinicopathologic and immunohistoche-mical analysis of 106 cases from the French sarcoma group. Am J Clin Pathol 2009; 131: 222-227.
7. Hornick JL, Dal Cin P, Fletcher CD. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol 2009; 33: 542-550.
8. Guillou L, Waden C, Coindre JM, et al. Proximal type epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistehcmical, and ultrastructural study of a series. Am J Surg Pathol 1997; 21: 130-146.
9. Kohashi K, Oda Y, Yamamoto H, et al. Reduced expression of SMARCB1/INI1 protein in synovial sarcoma. Mod Pathol 2010; 23: 981-990.
10. Argyrakos T, KopakaM, Karagkounis G, et al. INI-1 and TLE1 expression in five synovial sarcomas diagnosed by fluorescent in situ hybridization. Virchows Arch 2012; 461 (Suppl 1): S224.
11. Kohashi K, Oda Y, Yamamoto H, et al. SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma. Am J Surg Pathol 2008; 32: 1168-1174.