A sex-specific effect of the CYP17A1 SNP rs11191548 on blood pressure in Chinese children

Journal of Human Hypertension

Volumn 26, Issue 12, 2012, Pages 731-736

  Wu, L ^a   Xi, B ^b   Zhang, M ^a   Shen, Y ^c   Zhao, X ^a   Wang, T ^a   Cheng, H ^a   Hou, D ^a   Liu, G ^d   Wang, X ^c   Mi, J ^a  

^a CAPITAL INSTITUTE OF PEDIATRICS   (China)

^b SHANDONG UNIVERSITY   (China)

^c Beijing Hypertension League Institute   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

CYP17A1; obesity; single nucleotide polymorphism

Indexed keywords

CYTOCHROME P450 17; CYTOCHROME P450 17A1; GENOMIC DNA; UNCLASSIFIED DRUG;

ARTICLE; BLOOD PRESSURE VARIABILITY; BODY MASS; BODY WEIGHT; CHILD; CHINESE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA SEQUENCE; FEMALE; GENETIC ASSOCIATION; GENETIC MODEL; HUMAN; HUMAN CELL; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBESITY; PREHYPERTENSION; SCHOOL CHILD; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CHILD; CHINA; COMORBIDITY; CROSS-SECTIONAL STUDIES; DIASTOLE; FEMALE; GENOTYPE; HUMANS; HYPERTENSION; MALE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEX FACTORS; STEROID 17-ALPHA-HYDROXYLASE; SYSTOLE;

EID: 84869508726     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2011.96     Document Type: Article

References (31)

1. Mittal BV, Singh AK. Hypertension in the developing world: challenges and opportunities. Am J Kidney Dis 2010; 55: 590-598.
2. World Health Organization. World Health Statistics 2008. World Health Organization: Geneva, Switzerland, 2008, pp 29-30.
3. Tikhonoff V, Zhang H, Richart T, Staessen JA. Blood pressure as a prognostic factor after acute stroke. Lancet Neurol 2009; 8: 938-948.
4. Rahmouni K, Correia ML, Haynes WG, Mark AL. Obesity-associated hypertension: new insights into mechanisms. Hypertension 2005p; 45: 9-14. (Pubitemid 40066405)
5. Virdis A, Ghiadoni L, Masi S, Versari D, Daghini E, Giannarelli C et al. Obesity in the childhood: a link to adult hypertension. Curr Pharm Des 2009; 15: 1063-1071.
6. Falkner B. Hypertension in children and adolescents: epidemiology and natural history. Pediatr Nephrol 2010; 25: 1219-1224.
7. Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G. Mechanisms of obesity-induced hypertension. Hypertens Res 2010; 33: 386-393.
8. Haberstick BC, Lessem JM, McQueen MB, Boardman JD, Hopfer CJ, Smolen A et al. Stable genes and changing environments: body mass index across adolescence and young adulthood. Behav Gene 2010; 40: 495-504.
9. Wang GY, Wang YH, Xu Q, Tong WJ, Gu ML, Wang J et al. Associations between RAS Gene polymorphisms, environmental factors and hypertension in Mongolian people. Eur J Epidemiol 2006; 21: 287-292.
10. Zuber MX, Simpson ER, Waterman MR. Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. Science 1986; 234: 1258-1261. (Pubitemid 17232368)
11. Martin RM, Lin CJ, Costa EM, de Oliveira ML, Carrilho A, Villar H et al. P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping. J Clin Endocrinol Metab 2003; 88: 5739-5746. (Pubitemid 38033044)
12. Dhir V, Ivison HE, Krone N, Shackleton CH, Doherty AJ, Stewart PM et al. Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Mol Endocrinol 2007; 21: 1958-1968. (Pubitemid 47173803)
13. Morris DJ, Souness GW, Brem AS, Oblin ME. Interactions of mineralocorticoids and glucocorticoids in epithelial target tissues. Kidney Int 2000; 57: 1370-1373. (Pubitemid 30207893)
14. Yang J, Cui B, Sun S, Shi T, Zheng S, Bi Y et al. Phenotype-genotype correlation in eight Chinese 17alpha-hydroxylase/17,20 lyase-deficiency patients with five novel mutations of CYP17A1 gene. J Clin Endocrinol Metab 2006; 91: 3619-3625. (Pubitemid 44402146)
15. Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009; 41: 666-676.
16. Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T et al. Blood pressure and hypertension are associated with 7 loci in the Japanese population. Circulation 2010; 121: 2302-2309.
17. Liu C, Li H, Qi Q, Lu L, Gan W, Loos RJ et al. Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans. J Hypertens 2011; 29: 70-75.
18. Shan XY, Xi B, Cheng H, Hou DQ, Wang Y, Mi J. Prevalence and behavioral risk factors of overweight and obesity among children aged 2-18 in Beijing, China. Int J Pediatr Obes 2010; 5: 383-389.
19. Marshall WA, Tanner JM. Puberty. In: Falkner F, Tanner JM (eds). Human Growth, Vol. 2 Plenum: New York, 1986, pp 171-210.
20. Mi J, Wand TY, Meng LH, Zhu GJ, Han SM, Zhong Y et al. Development of blood pressure reference standards for Chinese children and adolescents. Chin J Evid Based Pediatr 2010; 5: 4-14.
21. Ji CY, Working Group on Obesity in China. Report on childhood obesity in China (1)-body mass index reference for screening overweight and obesity in Chinese school-age children. Biomed Environ Sci 2005; 18: 390-400.
22. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res 1996; 6: 986-994. (Pubitemid 26388091)
23. Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990; 44: 45-60. (Pubitemid 20177198)
24. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc B 1995; 57: 289-300.
25. Singh AS, Mulder C, Twisk JW, van Mechelen W, Chinapaw MJ. Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev 2008; 9: 474-488.
26. Kumanyika SK, Obarzanek E, Stettler N, Bell R, Field AE, Fortmann SP et al. Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: a scientific statement from American Heart Association Council on Epidemiology and Prevention, Interdisciplinary Committee for Prevention (formerly the expert panel on population and prevention science). Circulation 2008; 118: 428-464.
27. Olson SH, Bandera EV, Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review. Am J Epidemiol 2007; 165: 235-245. (Pubitemid 46174747)
28. Olson SH, Orlow I, Bayuga S, Sima C, Bandera EV, Pulick K et al. Variants in hormone biosynthesis genes and risk of endometrial cancer. Cancer Cause Control 2008; 19: 955-963.
29. Skibola CF, Bracci PM, Paynter RA, Forrest MS, Agana L, Woodage T et al. Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma. Br J Haematol 2005; 129: 618-621. (Pubitemid 40825823)
30. Zhang MX, Mi J, Li M, Zhao XY, Cheng H, Hou DQ. Relationship between obesity phenotypes and adipocytokines in children. J Appl Clin Pediatr 2008; 23: 580-583.
31. Cui Z, Huxley R, Wu Y, Dibley MJ. Temporal trends in overweight and obesity of children and adolescents from nine Provinces in China from 1991-2006. Int J Pediatr Obes 2010; 5: 365-374.