Evaluation of a point-of-care test based on deamidated gliadin peptides for celiac disease screening in a large pediatric population

European Journal of Gastroenterology and Hepatology

Volumn 24, Issue 12, 2012, Pages 1418-1423

  Bienvenu, Françoise ^a   Besson Duvanel, Cécile ^c   Seignovert, Camille ^a   Rouzaire, Paul ^a   Lachaux, Alain ^b   Bienvenu, Jacques ^a  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b Department of Gastroenterology   (France)

^c Augurix SA   (Switzerland)

Author keywords

celiac disease; deamidated gliadin peptides; point of care diagnostic test

Indexed keywords

GLIADIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CELIAC DISEASE; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; IMMUNOGLOBULIN A DEFICIENCY; INFANT; INTESTINE BIOPSY; MAJOR CLINICAL STUDY; MALE; POINT OF CARE TESTING; PRIORITY JOURNAL; SCREENING TEST; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; AGE FACTORS; AUTOANTIBODIES; BIOLOGICAL MARKERS; BIOPSY; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLIADIN; HUMANS; IGA DEFICIENCY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFANT; MALE; MASS SCREENING; PEPTIDE FRAGMENTS; POINT-OF-CARE SYSTEMS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; TRANSGLUTAMINASES; YOUNG ADULT;

EID: 84869505375     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3283582d95     Document Type: Article

References (27)

1. Tack GJ, Verbeek WH, Schreurs MW, Mulder CJ. The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat Rev Gastroenterol Hepatol 2010; 7:204-213.
2. Kaukinen K, Lindfors K, Collin P, Koskinen O, Mäki M. Coeliac disease - a diagnostic and therapeutic challenge. Clin Chem Lab Med 2010; 48:1205-1216.
3. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007; 26:1217-1225.
4. Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L, et al. Rotavirus infection frequency, risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006; 101:2333-2340.
5. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997; 3:797-801.
6. Tursi A, Brandimarte G, Giorgetti GM, Gigliobianco A, Lombardi D, Gasbarrini G. Low prevalence of antigliadin and anti-endomysium antibodies in subclinical/silent celiac disease. Am J Gastroenterol 2001; 96:1507-1510.
7. Vahedi K, Mascart F, Mary JY, Laberenne JE, Bouhinik Y, Morin MC, et al. Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. Am J Gastroenterol 2003; 98:1079-1087.
8. Schwertz E, Kahlenberg F, Sack U, Richter T, Stern M, Conrad K, et al. Serologic assay based on gliadin-related nonapeptides as a highly sensitive and specific diagnostic aid in celiac disease. Clin Chem 2004; 50:2370-2375.
9. Niveloni S, Sugai E, Cabanne A, Vazquez H, Argonz J, Smecuol E, et al. Antibodies against synthetic deamidated gliadin peptides as predictors of celiac disease: prospective assessment in an adult population with a high pretest probability of disease. Clin Chem 2007; 53:2186-2192.
10. Van de Wal Y, Kooy Y, van Veelen P, Peña S, Mearin L, Papadopoulos G, et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161:1585-1588.
11. Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and non-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003; 163:286-292.
12. Ravikumara M, Nootigattu VKT, Sandhu BK. Ninety percentage of celiac disease is being missed. J Pediatr Gastroenterol Nutr 2007; 45:497-499.
13. Davidson AGF, Campbell JA. Celiac disease and dermatitis herpetiformis: national survey indicates delays in diagnosis. Can Fam Physician 1992; 38:2604-8.
14. Hershcovici T, Leshno M, Goldin E, Shamir R, Israeli E. Cost effectiveness of mass screening for coeliac disease is determined by time-delay to diagnosis and quality of life on a gluten-free diet. Aliment Pharmacol Ther 2010; 31:901-910.
15. Green PHR, Neugut AI, Naiyer AJ, Edwards ZC, Gabinelle S, Chinburapa V. Economic benefits of increased diagnosis of celiac disease in a national managed care population in the United States. J Insur Med 2008; 40:218-228.
16. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999; 11:1185-1194.
17. Valletta E, Fornaro M, Pecori S, Zanoni G. Selective immunoglobulin A deficiency and celiac disease: let's give serology a chance. J Investig Allergol Clin Immunol 2011; 21:242-244.
18. Dean AG, Sullivan KM, Soe MM. OpenEpi: Open source epidemiologic statistics for public health, version 2.3.1, updated 23 June 2011. Available at: http://www.OpenEpi.com [Accessed 21 December 2011].
19. Rubio-Tapia A, Murray JA. Celiac disease. Curr Opin Gastroenterol 2010; 26:116-122.
20. Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, et al. ESPGHAN guidelines for the diagnosis of coeliac disease in children and adolescents: an evidence-based approach. J Pediatr Gastroenterol Nutr 2012; 54:136-160.
21. Prause C, Ritter M, Probst C, Daehnrich C, SchlumbergerW, Komorowski L, et al. Antibodies against deamidated gliadin as new and accurate biomarkers of childhood coeliac disease. J Pediatr Gastroenterol Nutr 2009; 49:52-58.
22. Cataldo F, Marino V, Bottaro G, Greco P, Ventura A. Celiac disease and selective immunoglobulin A deficiency. J Pediatr 1997; 131:306-308.
23. Maki M, Hallstrom O, Huupponen T, Vesikari T, Visakorpi JK. Increased prevalence of coeliac disease in diabetes. Arch Dis Child 1984; 59:739-742.
24. Peretti N, Bienvenu F, Bouvet C, Fabien N, Tixier F, Thivolet C, et al. The temporal relationship between the onset of type I diabetes and celiac disease: a study based on immunoglobulin A antitransglutaminase screening. Pediatrics 2004; 113:418-422.
25. Kurppa K, Lindfors K, Collin P, Saavalainen P, Partanen J, Haimila K, et al. Antibodies against deamidated gliadin peptides in early-stage celiac disease. J Clin Gastroenterol 2011; 45:673-678.
26. Corrao G, Corazza GR, Andreani ML, Torchio P, Valentini RA, Galatola G, et al. Serological screening of coeliac disease: choosing the optimal procedure according to various prevalence values. Gut 1994; 35:771-775.
27. Mizen L. Simtomaxs: a new screening tool for coeliac disease. Br J Healthc Manage 2012; 18:27-32.