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Volumn 132, Issue 2, 2013, Pages 472-484

Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer

Author keywords

BST2; endometrial cancer; iTRAQ; molecular target; plasma membrane

Indexed keywords

ADAM10 ENDOPEPTIDASE; BASAL CELL ADHESION MOLECULE; BONE MARROW STROMAL ANTIGEN 2; BONE MARROW STROMAL ANTIGEN 2 ANTIBODY; CELL MEMBRANE PROTEIN; CELL SURFACE PROTEIN; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; CUB DOMAIN CONTAINING PROTEIN 1; DESMOGLEIN 2; JUNCTIONAL ADHESION MOLECULE A; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MONOCLONAL ANTIBODY; NERVE CELL ADHESION MOLECULE L1; SYNDECAN 4; TUMOR NECROSIS FACTOR RECEPTOR 5; UNCLASSIFIED DRUG;

EID: 84869503250     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27679     Document Type: Article
Times cited : (59)

References (48)
  • 1
    • 13244270361 scopus 로고    scopus 로고
    • CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma
    • Marcus R, Imrie K, Belch A, et al. CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood 2005; 105: 1417-23.
    • (2005) Blood , vol.105 , pp. 1417-1423
    • Marcus, R.1    Imrie, K.2    Belch, A.3
  • 2
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 3
    • 77954730167 scopus 로고    scopus 로고
    • Plasma membrane proteomics and its application in clinical cancer biomarker discovery
    • Leth-Larsen R, Lund RR, Ditzel HJ,. Plasma membrane proteomics and its application in clinical cancer biomarker discovery. Mol Cell Proteomics 2010; 9: 1369-82.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1369-1382
    • Leth-Larsen, R.1    Lund, R.R.2    Ditzel, H.J.3
  • 4
    • 0037470247 scopus 로고    scopus 로고
    • Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function
    • Shin BK, Wang H, Yim AM, et al. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem 2003; 278: 7607-16.
    • (2003) J Biol Chem , vol.278 , pp. 7607-7616
    • Shin, B.K.1    Wang, H.2    Yim, A.M.3
  • 5
    • 1842529218 scopus 로고    scopus 로고
    • Proteomic analysis of integral plasma membrane proteins
    • Zhao Y, Zhang W, Kho Y,. Proteomic analysis of integral plasma membrane proteins. Anal Chem 2004; 76: 1817-23.
    • (2004) Anal Chem , vol.76 , pp. 1817-1823
    • Zhao, Y.1    Zhang, W.2    Kho, Y.3
  • 6
    • 0036583926 scopus 로고    scopus 로고
    • Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
    • Ong SE, Blagoev B, Kratchmarova I, et al. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 2002; 1: 376-86.
    • (2002) Mol Cell Proteomics , vol.1 , pp. 376-386
    • Ong, S.E.1    Blagoev, B.2    Kratchmarova, I.3
  • 7
    • 67650189497 scopus 로고    scopus 로고
    • Applications of proteomics in the study of inflammatory bowel diseases: Current status and future directions with available technologies
    • Alex P, Gucek M, Li X,. Applications of proteomics in the study of inflammatory bowel diseases: current status and future directions with available technologies. Inflamm Bowel Dis 2009; 15: 616-29.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 616-629
    • Alex, P.1    Gucek, M.2    Li, X.3
  • 8
    • 35648942133 scopus 로고    scopus 로고
    • 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease
    • Choe L, D'Ascenzo M, Relkin NR, et al. 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease. Proteomics 2007; 7: 3651-60.
    • (2007) Proteomics , vol.7 , pp. 3651-3660
    • Choe, L.1    D'Ascenzo, M.2    Relkin, N.R.3
  • 11
    • 2942657617 scopus 로고    scopus 로고
    • Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: A Gynecologic Oncology Group Study
    • Fleming GF, Brunetto VL, Cella D, et al. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 2004; 22: 2159-66.
    • (2004) J Clin Oncol , vol.22 , pp. 2159-2166
    • Fleming, G.F.1    Brunetto, V.L.2    Cella, D.3
  • 12
    • 33847662544 scopus 로고    scopus 로고
    • Chemotherapy for advanced, recurrent or metastatic endometrial cancer: A systematic review of Cochrane collaboration
    • Humber CE, Tierney JF, Symonds RP, et al. Chemotherapy for advanced, recurrent or metastatic endometrial cancer: a systematic review of Cochrane collaboration. Ann Oncol 2007; 18: 409-20.
    • (2007) Ann Oncol , vol.18 , pp. 409-420
    • Humber, C.E.1    Tierney, J.F.2    Symonds, R.P.3
  • 13
    • 0344844550 scopus 로고    scopus 로고
    • Successful immortalization of endometrial glandular cells with normal structural and functional characteristics
    • Kyo S, Nakamura M, Kiyono T, et al. Successful immortalization of endometrial glandular cells with normal structural and functional characteristics. Am J Pathol 2003; 163: 2259-69.
    • (2003) Am J Pathol , vol.163 , pp. 2259-2269
    • Kyo, S.1    Nakamura, M.2    Kiyono, T.3
  • 14
    • 33748649087 scopus 로고    scopus 로고
    • Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements
    • Mizumoto Y, Kyo S, Ohno S, et al. Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements. Oncogene 2006; 25: 5673-82.
    • (2006) Oncogene , vol.25 , pp. 5673-5682
    • Mizumoto, Y.1    Kyo, S.2    Ohno, S.3
  • 15
    • 23044494298 scopus 로고    scopus 로고
    • Identification and relative quantification of membrane proteins by surface biotinylation and two-dimensional peptide mapping
    • Scheurer SB, Rybak JN, Roesli C, et al. Identification and relative quantification of membrane proteins by surface biotinylation and two-dimensional peptide mapping. Proteomics 2005; 5: 2718-28.
    • (2005) Proteomics , vol.5 , pp. 2718-2728
    • Scheurer, S.B.1    Rybak, J.N.2    Roesli, C.3
  • 16
    • 0032811719 scopus 로고    scopus 로고
    • A novel cytolysis assay using fluorescent labeling and quantitative fluorescent scanning technology
    • Roden MM, Lee KH, Panelli MC, et al. A novel cytolysis assay using fluorescent labeling and quantitative fluorescent scanning technology. J Immunol Methods 1999; 226: 29-41.
    • (1999) J Immunol Methods , vol.226 , pp. 29-41
    • Roden, M.M.1    Lee, K.H.2    Panelli, M.C.3
  • 17
    • 0034765888 scopus 로고    scopus 로고
    • Calcein-acetyoxymethyl cytotoxicity assay: Standardization of a method allowing additional analyses on recovered effector cells and supernatants
    • Neri S, Mariani E, Meneghetti A, et al. Calcein-acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants. Clin Diagn Lab Immunol 2001; 8: 1131-5.
    • (2001) Clin Diagn Lab Immunol , vol.8 , pp. 1131-1135
    • Neri, S.1    Mariani, E.2    Meneghetti, A.3
  • 18
    • 57649086769 scopus 로고    scopus 로고
    • Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells
    • Wang W, Nishioka Y, Ozaki S, et al. Chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells. Lung Cancer 2009; 63: 23-31.
    • (2009) Lung Cancer , vol.63 , pp. 23-31
    • Wang, W.1    Nishioka, Y.2    Ozaki, S.3
  • 19
    • 11244265898 scopus 로고    scopus 로고
    • Identification and validation of cell surface antigens for antibody targeting in oncology
    • Carter P, Smith L, Ryan M,. Identification and validation of cell surface antigens for antibody targeting in oncology. Endocr Relat Cancer 2004; 11: 659-87.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 659-687
    • Carter, P.1    Smith, L.2    Ryan, M.3
  • 20
    • 0034755201 scopus 로고    scopus 로고
    • Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation
    • Mutter GL, Baak JP, Fitzgerald JT, et al. Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformation. Gynecol Oncol 2001; 83: 177-85.
    • (2001) Gynecol Oncol , vol.83 , pp. 177-185
    • Mutter, G.L.1    Baak, J.P.2    Fitzgerald, J.T.3
  • 21
    • 33947507141 scopus 로고    scopus 로고
    • Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling
    • Wong YF, Cheung TH, Lo KW, et al. Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling. Oncogene 2007; 26: 1971-82.
    • (2007) Oncogene , vol.26 , pp. 1971-1982
    • Wong, Y.F.1    Cheung, T.H.2    Lo, K.W.3
  • 22
    • 0036549767 scopus 로고    scopus 로고
    • Discordant protein and mRNA expression in lung adenocarcinomas
    • Chen G, Gharib TG, Huang CC, et al. Discordant protein and mRNA expression in lung adenocarcinomas. Mol Cell Proteomics 2002; 1: 304-13.
    • (2002) Mol Cell Proteomics , vol.1 , pp. 304-313
    • Chen, G.1    Gharib, T.G.2    Huang, C.C.3
  • 23
    • 20144368638 scopus 로고    scopus 로고
    • Integrated genomic and proteomic analyses of gene expression in mammalian cells
    • Tian Q, Stepaniants SB, Mao M, et al. Integrated genomic and proteomic analyses of gene expression in mammalian cells. Mol Cell Proteomics 2004; 3: 960-9.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 960-969
    • Tian, Q.1    Stepaniants, S.B.2    Mao, M.3
  • 24
    • 27244450053 scopus 로고    scopus 로고
    • Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma
    • Mimura K, Kono K, Hanawa M, et al. Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res 2005; 11: 4898-904.
    • (2005) Clin Cancer Res , vol.11 , pp. 4898-4904
    • Mimura, K.1    Kono, K.2    Hanawa, M.3
  • 25
    • 33746047673 scopus 로고    scopus 로고
    • Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity
    • van Meerten T, van Rijn RS, Hol S, et al. Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity. Clin Cancer Res 2006; 12: 4027-35.
    • (2006) Clin Cancer Res , vol.12 , pp. 4027-4035
    • Van Meerten, T.1    Van Rijn, R.S.2    Hol, S.3
  • 26
    • 29144462024 scopus 로고    scopus 로고
    • Comparison of normal and breast cancer cell lines using proteome, genome, and interactome data
    • Patwardhan AJ, Strittmatter EF, Camp DG II, et al. Comparison of normal and breast cancer cell lines using proteome, genome, and interactome data. J Proteome Res 2005; 4: 1952-60.
    • (2005) J Proteome Res , vol.4 , pp. 1952-1960
    • Patwardhan, A.J.1    Strittmatter, E.F.2    Camp, I.I.D.G.3
  • 27
    • 55749112976 scopus 로고    scopus 로고
    • Membrane proteins and membrane proteomics
    • Tan S, Tan HT, Chung MC,. Membrane proteins and membrane proteomics. Proteomics 2008; 8: 3924-32.
    • (2008) Proteomics , vol.8 , pp. 3924-3932
    • Tan, S.1    Tan, H.T.2    Chung, M.C.3
  • 28
    • 55549098927 scopus 로고    scopus 로고
    • Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation
    • Conn EM, Madsen MA, Cravatt BF, et al. Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation. J Biol Chem 2008; 283: 26518-27.
    • (2008) J Biol Chem , vol.283 , pp. 26518-26527
    • Conn, E.M.1    Madsen, M.A.2    Cravatt, B.F.3
  • 29
    • 50949085145 scopus 로고    scopus 로고
    • Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells
    • Kischel P, Guillonneau F, Dumont B, et al. Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. Neoplasia 2008; 10: 1014-20.
    • (2008) Neoplasia , vol.10 , pp. 1014-1020
    • Kischel, P.1    Guillonneau, F.2    Dumont, B.3
  • 30
    • 52049093719 scopus 로고    scopus 로고
    • Quantitative analysis of surface plasma membrane proteins of primary and metastatic melanoma cells
    • Qiu H, Wang Y,. Quantitative analysis of surface plasma membrane proteins of primary and metastatic melanoma cells. J Proteome Res 2008; 7: 1904-15.
    • (2008) J Proteome Res , vol.7 , pp. 1904-1915
    • Qiu, H.1    Wang, Y.2
  • 31
    • 0031954925 scopus 로고    scopus 로고
    • Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms
    • Wallin E, von Heijne G,. Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms. Protein Sci 1998; 7: 1029-38.
    • (1998) Protein Sci , vol.7 , pp. 1029-1038
    • Wallin, E.1    Von Heijne, G.2
  • 32
    • 0141518671 scopus 로고    scopus 로고
    • L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas
    • Fogel M, Gutwein P, Mechtersheimer S, et al. L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet 2003; 362: 869-75.
    • (2003) Lancet , vol.362 , pp. 869-875
    • Fogel, M.1    Gutwein, P.2    Mechtersheimer, S.3
  • 33
    • 77950820633 scopus 로고    scopus 로고
    • Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
    • Mamat S, Ikeda J, Enomoto T, et al. Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma. Oncol Rep 2010; 23: 1221-7.
    • (2010) Oncol Rep , vol.23 , pp. 1221-1227
    • Mamat, S.1    Ikeda, J.2    Enomoto, T.3
  • 34
    • 0028101333 scopus 로고
    • A novel membrane antigen selectively expressed on terminally differentiated human B cells
    • Goto T, Kennel SJ, Abe M, et al. A novel membrane antigen selectively expressed on terminally differentiated human B cells. Blood 1994; 84: 1922-30.
    • (1994) Blood , vol.84 , pp. 1922-1930
    • Goto, T.1    Kennel, S.J.2    Abe, M.3
  • 35
    • 0033583795 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells
    • Ohtomo T, Sugamata Y, Ozaki Y, et al. Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Biophys Res Commun 1999; 258: 583-91.
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 583-591
    • Ohtomo, T.1    Sugamata, Y.2    Ozaki, Y.3
  • 36
    • 0347320774 scopus 로고    scopus 로고
    • Identification of genes expressed in malignant cells that promote invasion
    • Walter-Yohrling J, Cao X, Callahan M, et al. Identification of genes expressed in malignant cells that promote invasion. Cancer Res 2003; 63: 8939-47.
    • (2003) Cancer Res , vol.63 , pp. 8939-8947
    • Walter-Yohrling, J.1    Cao, X.2    Callahan, M.3
  • 37
    • 57349089289 scopus 로고    scopus 로고
    • Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models
    • Kawai S, Azuma Y, Fujii E, et al. Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models. Cancer Sci 2008; 99: 2461-6.
    • (2008) Cancer Sci , vol.99 , pp. 2461-2466
    • Kawai, S.1    Azuma, Y.2    Fujii, E.3
  • 38
    • 63949083216 scopus 로고    scopus 로고
    • HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody
    • Wang W, Nishioka Y, Ozaki S, et al. HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody. Cancer Immunol Immunother 2009; 58: 967-76.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 967-976
    • Wang, W.1    Nishioka, Y.2    Ozaki, S.3
  • 39
    • 38549095979 scopus 로고    scopus 로고
    • Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    • Neil SJ, Zang T, Bieniasz PD,. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature 2008; 451: 425-30.
    • (2008) Nature , vol.451 , pp. 425-430
    • Neil, S.J.1    Zang, T.2    Bieniasz, P.D.3
  • 40
    • 59649124256 scopus 로고    scopus 로고
    • Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin
    • Jouvenet N, Neil SJ, Zhadina M, et al. Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. J Virol 2009; 83: 1837-44.
    • (2009) J Virol , vol.83 , pp. 1837-1844
    • Jouvenet, N.1    Neil, S.J.2    Zhadina, M.3
  • 41
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams GP, Weiner LM,. Monoclonal antibody therapy of cancer. Nat Biotechnol 2005; 23: 1147-57.
    • (2005) Nat Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 42
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K, Takaoka A,. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 2006; 6: 714-27.
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 43
    • 0038724274 scopus 로고    scopus 로고
    • Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways
    • Matsuda A, Suzuki Y, Honda G, et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 2003; 22: 3307-18.
    • (2003) Oncogene , vol.22 , pp. 3307-3318
    • Matsuda, A.1    Suzuki, Y.2    Honda, G.3
  • 44
    • 0028869986 scopus 로고
    • Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
    • Shultz LD, Schweitzer PA, Christianson SW, et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 1995; 154: 180-91.
    • (1995) J Immunol , vol.154 , pp. 180-191
    • Shultz, L.D.1    Schweitzer, P.A.2    Christianson, S.W.3
  • 45
    • 33846188062 scopus 로고    scopus 로고
    • Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin
    • Mulgrew K, Kinneer K, Yao XT, et al. Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin. Mol Cancer Ther 2006; 5: 3122-9.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3122-3129
    • Mulgrew, K.1    Kinneer, K.2    Yao, X.T.3
  • 46
    • 80052012662 scopus 로고    scopus 로고
    • In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans
    • Erikson E, Adam T, Schmidt S, et al. In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/ tetherin in humans. Proc Natl Acad Sci USA 2011; 108: 13688-93.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 13688-13693
    • Erikson, E.1    Adam, T.2    Schmidt, S.3
  • 47
    • 79960970502 scopus 로고    scopus 로고
    • A phase i study of the safety, tolerance, pharmokinetics, antigenicity and efficacy of a single intravenous dose of AHM followed by multiple doses of intravenous AHM in patients with multiple myeloma
    • Powles R, Sirohi B, Morgan G, et al. A phase I study of the safety, tolerance, pharmokinetics, antigenicity and efficacy of a single intravenous dose of AHM followed by multiple doses of intravenous AHM in patients with multiple myeloma. Blood 2001; 98: 165A.
    • (2001) Blood , vol.98
    • Powles, R.1    Sirohi, B.2    Morgan, G.3
  • 48
    • 84861690919 scopus 로고    scopus 로고
    • Antibody-based therapies in multiple myeloma
    • Tai Y-T, Anderson KC,. Antibody-based therapies in multiple myeloma. Bone Marrow Res 2011; 2011: 924058.
    • (2011) Bone Marrow Res , vol.2011 , pp. 924058
    • Tai, Y.-T.1    Anderson, K.C.2


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