Human papillomavirus related head and neck cancer survival: A systematic review and meta-analysis

Oral Oncology

Volumn 48, Issue 12, 2012, Pages 1191-1201

  O'Rorke, M A ^a   Ellison, M V ^b   Murray, L J ^a   Moran, M ^b   James, J ^b   Anderson, L A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Head and neck cancer; Human Papillomavirus (HPV); Meta analysis; Oropharyngeal; Survival; Systematic review; Tonsil

Indexed keywords

CANCER MORTALITY; CANCER SURVIVAL; DISEASE FREE INTERVAL; DISEASE SPECIFIC SURVIVAL; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; OROPHARYNX CARCINOMA; OVERALL SURVIVAL; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; RECURRENCE FREE SURVIVAL; REVIEW; SQUAMOUS CELL CARCINOMA; SYSTEMATIC REVIEW; TONSIL CARCINOMA; WART VIRUS;

HEAD AND NECK NEOPLASMS; HUMANS; PAPILLOMAVIRIDAE; SURVIVAL ANALYSIS;

EID: 84869503191     PISSN: 13688375     EISSN: 18790593     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2012.06.019     Document Type: Review

References (108)

1. D.M. Parkin, S.L. Whelan, J. Ferlay, and H. Storm Cancer incidence in five continents 2005 International Agency for Research on Cancer
2. A. Santarelli, L. Lo Russo, F. Bambini, G. Campisi, and L. Lo Muzio New perspectives in medical approach to therapy of head and neck squamous cell carcinoma Minerva Stomatol 58 2009 445 452
3. S. Syrjanen Human papillomavirus (HPV) in head and neck cancer J Clin Virol 32 2005 59 66
4. H. Mehanna, V. Paleri, C.M.L. West, and C. Nutting Head and neck cancer - Part 1: epidemiology, presentation, and prevention BMJ 341 2010 663 666
5. L. Hammarstedt, D. Lindquist, H. Dahlstrand, M. Romanitan, and L.O. Dahlgren Human papillomavirus as a risk factor for the increase of tonsillar cancer Int J Cancer 119 2006 2620 2623
6. T. Ramqvist, and T. Dalianis An epidemic of oropharyngeal squamous cell carcinoma (OSCC) due to human papillomavirus (HPV) Infection and aspects of treatment and prevention Anticancer Res 31 2011 1515 1519
7. C.H. Shiboski, B.L. Schmidt, and R.C. Jordan Tongue and tonsil carcinoma: increasing trends in the US population ages 20-44 years Cancer 103 2005 1843 1849
8. B.J. Braakhuis, O. Viser, and C.R. Leemans Oral and oralpharyngeal cancer in the Netherlands between 1989 and 2006: increasing incidence, but not in young adults Oral Oncol 45 2009 e85 9
9. A.K. Chaturvedi, E.A. Engels, W.F. Anderson, and M.L. Gillison Incidence trends for human papillomavirus related and unrelated oral squamous cell carcinomas in the United States J Clin Oncol 26 2008 612 619
10. D.I. Conway, D.L. Stockton, K.A. Warnakulasuriya, G. Ogden, and L.M. Macpherson Incidence of oral and oropharyngeal cancer in the United Kingdom (1990-1999) - recent trends and regional variation Oral Oncol 42 2006 586 592
11. L. Hammarstedt, H. Dahlstrand, D. Lindquist, L. Onelov, M. Ryott, and J. Luo The incidence of tonsillar cancer in Sweden is still increasing Acta Otolaryngol 127 2007 988 992
12. A. Nasman, P. Attner, L. Hammarstedt, J. Du, and M. Eriksson Incidence of Human papillomavirus (HPV)-positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer 125 2009 362 366
13. K.L. Robinson, and G.J. Macfarlane Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing? Oral Oncol 39 2003 31 36
14. M. Romanitan, A. Nasman, T. Ramqvist, and H. Dahlstrand Human papillomavirus frequency in oral and oropharyngeal cancer in Greece Anticancer Res 28 2008 2077 2080
15. C.D. Llewellyn, N.W. Johnson, and K.A. Warnakulasuriya Risk factors for squamous cell carcinoma of the oral cavity in young people - a comprehensive literature review Oral Oncol 37 2001 401 418
16. M. Toner, and E.M. O'Regan Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1 Head and Neck Pathol 3 2009 246 248
17. S. Marur, G. D'Souza, W.H. Westra, and A.A. Forastiere HPV-associated head and neck cancer: a virus-related cancer epidemic Lancet Oncology 11 2010 781 789
18. H.E. Karim-Kos, E. de Vriesa, I. Soerjomatarama, V. Lemmensa, S. Siesling, and J.W. Coebergh Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s Eur J cancer 44 2008 1345 1389
19. S.C. Patel, W.R. Carpenter, S. Tyree, M. Everett Couch, and M. Weissler Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18-44 years J Clin Oncol 29 2011 1488 1494
20. K.K. Ang, J. Harris, R. Wheeler, R. Weber, D.I. Rosenthal, and P.F. Nguyen-Tan Human papillomavirus and survival of patients with oropharyngeal cancer New Engl J Med 363 2010 24 35
21. G. D'Souza, A.R. Kreimer, G.M. Clifford, P. Boyle, S. Franceschi, and R. Viscidi Case-control study of human papillomavirus and oropharyngeal cancer N Engl J Med 356 2007 1944 1956
22. E.M. Smith, J.M. Ritchie, K.F. Summersgill, J.P. Klussmann, J.H. Lee, and D.H. Wang Age, sexual behaviour and human papillomavirus infection in oral cavity and oropharyngeal cancers Int J Cancer 108 2004 766 772
23. J.E. Heck, J. Berthiller, S. Vaccarella, D.M. Winn, and E.M. Smith Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium Int J Epidemiol 39 2010 166 181
24. A. Psyrri, P. Gouveris, and J.B. Vermorken Human papillomavirus-related head and neck tumors: clinical and research implication Curr Opin Oncol 21 2009 201 205
25. N.P. Nguyen, B. Hong Ly, M. Betz, and V. Vinh-Hung Importance of age as a prognostic factor for tonsillar carcinoma Ann Surg Oncol 17 2010 2570 2577
26. S. Marur, and A.A. Forastiere Head and neck cancer: changing epidemiology, diagnosis, and treatment Mayo Clin Proc 83 2008 489 501
27. L. Vidal, and M.L. Gillison Human papillomavirus in HNSCC: recognition of a distinct disease type Hematol Oncol Clin North Am 22 2008 1125 1142
28. S.J. Smeets, R.H. Brakenhoff, Y. Bauke, W.N. Van Wieringen, M.A. Van de Wiel, and C.R. Leemans Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis Cell Oncol 31 2009 291 300
29. M.L. Gillison, W.M. Koch, R.B. Capone, M. Spafford, and W.H. Westra Evidence for a causal association between human papillomavirus and a subset of head and neck cancers J Natl Cancer Inst 92 2000 702 720
30. H. Mellin, S. Friesland, R. Lewensohn, T. Dalianis, and E. Munck-Wikland Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse and survival Int J Cancer 89 2000 300 304
31. E.M. Sturgis, and P.M. Cinciripini Trends in head and neck cancer incidence in relation to smoking prevalence. an emerging epidemic of human papillomavirus-associate cancers? Cancer 110 2007 1429 1435
32. A.R. Krieimer, G.M. Clifford, and P. Boyle Human papillomavirus types in head and neck squamous call carcinomas worldwide: a systematic review Cancer Epidemiol Biomarkers Prev 14 2005 467 475
33. N. Termine, V. Panzarella, S. Falaschini, A. Russo, D. Matranga, and L. Lo Muzio HPV in oral squamous cell carcinoma vs. head and neck squamous cell carcinoma biopsies: a meta-analysis (1988-2007) Ann Oncol 19 2008 1681 1690
34. C.G.L. Hobbs, J.A.C. Sterne, C.G.L. Bailey, R.S. Heyderman, M.A. Birchall, and S.J. Thomas Human papillomavirus and head and neck cancer: a systematic review and meta-analysis Clin Otolaryngol 31 2006 259 266
35. F. Dayyani, C. Etzel, M. Liu, C. Ho, S.M. Lippman, and A.S. Tsao Meta-analysis of the impact of human papillomavirus on cancer risk and overall survival in head and neck squamous cell carcinoma Head Neck Oncol 2 2010
36. C.C.R. Ragin, and E. Taioli Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis Int J Cancer 121 2007 1813 1820
37. D. Moher, A. Linberati, J. Tetzlaff, D.G. Altman, and T.P. Group Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement PLoS MED 6 2009 e1000097
38. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Cont Clin Trials 7 1986 177 178
39. C.B. Begg, and M. Mazumdar Operating characteristic of a rank correlation test for publication bias Biometrics 50 1994 1088 1101
40. M. Egger, G. Davey Smith, M. Schneider, and C. Minder Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634
41. C.S. Furniss, M.D. McClean, J.F. Smith, J. Bryan, H.H. Nelson, and E.S. Peters Human papillomavirus 16 and head and neck squamous cell carcinoma Int J Cancer 120 2007 2386 2392
42. M.L. Gillison, J. Harris, W. Westra, C. Chung, R. Jordan, and D. Rosenthal Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129 J Clin Oncol 27 2009 6003
43. S.F. Preuss, A. Weinell, M. Molitor, M. Stenner, R. Semrau, and U. Drebber Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer Brit J Cancer 98 2008 627 632
44. H.C. Hafkamp, J.J. Manni, A. Haesevoets, A.C. Voogd, M. Schepers, and F.J. Bot Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas Int J Cancer 122 2008 2656 2664
45. J.M. Ritchie, E.M. Smith, K.F. Summersgill, H.T. Hoffman, D. Wang, and J.P. Klussmann Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx Int J Cancer 104 2003 336 344
46. S. Begum, and W.H. Westra Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status Am J Surg Pathol 32 2008 1044 1050
47. R.D. Chernock, J.S. Lewis Jr, Q. Zhang, and S.K. El-Mofty Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma Human Pathol 41 2010 1016 1023
48. M.R. Posner, J.H. Lorch, O. Goloubeva, M. Tan, L.M. Schumaker, and N.J. Sarlis Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial Ann Oncol 22 2011 1071 1077
49. P.M. Weinberger, M.A. Merkley, S.S. Khichi, J.R. Lee, A. Psyrri, and L.L. Jackson Human papillomavirus-active head and neck cancer and ethnic health disparities Laryngoscope 120 2010 1531 1537
50. I.B. Paz, N. Cook, T. Odom-Maryon, Y. Xie, and S.P. Wilczynski Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer's tonsillar ring Cancer 79 1997 595 604
51. M.C. de Jong, J. Pramana, J.L. Knegjens, A.J.M. Balm, M.W.M. van den Brekel, and M. Hauptmann HPV and high-risk gene expression profiles predict response to chemoradiotherapy in head and neck cancer, independent of clinical factors Radiother Oncol 95 2010 365 370
52. M. Ritta, M. De Andrea, M. Mondini, J. Mazibrada, C. Giordano, and G. Pecorari Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor progression Head Neck 31 2009 318 327
53. C.S. Kong, B. Narasimhan, C. Hongbin, S. Kwok, J.P. Erickson, and A. Koong The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas Int J Radiation Oncology Biol Phys 74 2009 553 561
54. L.D. Koutcher, E. Sherman, D. Carlson, N. Katabi, M. Fury, and S. Wolden Cisplatin (CDDP) and radiation (RT) vs. cetuximab (C) and RT in the context of human papillomavirus (HPV) and P16 in the treatment of locally advanced head and neck cancer (LAHNC) Int J Radiation Oncology Biol Phys 78 2010 S63
55. K.T. Kuo, C.H. Hsiao, C.H. Lin, L.T. Kuo, S.H. Huang, and M.C. Lin The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma - molecular basis and predicting favourable outcome Modern Pathol 21 2008 376 386
56. K. Lindel, K.T. Beer, J. Laissue, R.H. Greiner, and D.M. Abersold Human papillomavirus positive squamous cell carcinoma of the oropharynx Cancer 92 2001 805 813
57. D. Zhao, Q.G. Xu, X.M. Chen, and M.W. Fan Human papillomavirus as an independent predictor in oral squamous cell cancer Int J Oral Sci 1 2009 119 125
58. D. Lindquist, M. Romanitan, L. Hammarstedt, A. Nasman, H. Dahlstrand, and J. Lindholm Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7 Molecular Oncol 1 2007 350 355
59. E.M. Smith, L.M. Rubenstein, H. Hoffman, T.H. Haugen, and L.P. Turek Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer Infect Agent Cancer 5 2010
60. J. Pintos, E.L. Franco, M.J. Black, J. Bergeron, and M. Arella Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract Cancer 85 1999 1903 1909
61. K. Rosenquist, J. Wennerberg, K. Annertz, E.B. Schildt, B.G. Hansson, and A. Bladstrom Recurrence in patients with oral and oropharyngeal squamous cell carcinoma: human papillomavirus and other risk factors Acta Oto-Laryngologica 127 2007 980 987
62. J.A.C. Sterne, M. Egger, and G. Davey-Smith Investigating and dealing with publication and other biases in meta-analysis BMJ 323 2001 101 105
63. P.D. Lacy, J.F. Piccirillo, M.G. Merritt, and M.R. Zequeira Head and neck squamous cell carcinoma: better to be young Arch Otolaryngol Head Neck Surg 122 2000 253 258
64. A. Bessell, A.-M. Glenny, S. Furness, J.E. Clarkson, R. Oliver, and D.I. Conway Intervention for the treatment of oral and oropharyngeal cancers: surgical treatment Cochrane Database of System Rev 2011
65. H. Mehanna, O. Olaleye, and L. Licitra Oropharyngeal cancer - is it time to change management according to human papilloma virus status? Curr Opin Otolaryngol Head Neck Surg 20 2012 120 124
66. J.K. Flohr, and J.H. Lee Identical but different: mechanism of cancer development and response to treatment for human papillomavirus-related and non-related squamous cell cancer of the head and neck S D Med 61 2008 453 455
67. A.H. Mendelsohn, C.K. Lai, I.P. Shintaku, D.A. Elashoff, S.M. Dubinett, and E. Abemayor Histopathologic findings of HPV and p16 positive HNSCC Laryngoscope 120 2010 1788 1794
68. K. Hannisdal, A. Schjolberg, P.M. De Angelis, M. Boysen, and O.P. Clausen Human papillomavirus (HPV)-positive tonsillar carcinomas are frequent and have a favourable prognosis in males in Norway Acta Oto-Laryngologica 130 2010 293 299
69. M.L. Gillison, T. Broutian, R.K. Pickard, Z.Y. Tong, W. Xiao, and L. Kahle Prevalence of oral HPV infection in the United States, 2009-2010 JAMA 307 2012
70. N. Muñoz, F.X. Bosch, S. de Sanjosé, R. Herrero, X. Castellsagué, and K.V. Shah Epidemiologic classification of human papilomavirus types associated with cervical cancer N Engl J Med 348 2003 518 527
71. C.C. Ragin, F. Modugno, and S.M. Gollin The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus J Dent Res 86 2007 104 114
72. K. Butz, C. Geisen, A. Ullman, D. Spitkovsky, and F. Hope-Seyler Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis Int J Cancer 68 1996 506 513
73. L. Mannarini, V. Kratochvil, L. Calabrese, L. Gomes Silva, P. Morbini, and J. Betka Human Papilloma Virus (HPV) in head and neck region: review of literature Acta Otorhinolaryngol Ital 29 2009 119 126
74. C.R. Leemans, J.M. Boudewijn, B.J.M. Braakhuis, and R.H. Brakenhoff The molecular biology of head and neck cancer Nat Rev Cancer 11 2011 9 22
75. A. Psyrri, E. Boutati, and S. Karageorgopoulou Human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines Anticancer Drugs 22 2011 586 590
76. M. Hampl, N. Wentzensen, S. Vinokurova, M. von Knebel-Doeberitz, C. Poremba, and H.G. Bender Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile J Cancer Res Clin Oncol 133 2007 235 245
77. S.L. McGovern, M.D. Williams, R.S. Weber, A. Sabichi, M.S. Chambers, and J.W. Martin Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: case report and comparison with Slaughter's model of field cancerization Head Neck 32 2010 1118 1124
78. M.L. Poeta, J. Manola, M.A. Goldwasser, A. Forastiere, N. Benoit, and J.A. Califano TP53 mutations and survival in squamous-cell carcinoma of the head and neck N Engl J Med 357 2007 2552 2561
79. J.S. Lewis, W.L. Thorstad, R.D. Chernock, B.H. Haughey, J.H. Yip, and Q. Zhang P16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumour HPV status Am J Surg Pathol 34 2010 1088 1096
80. G. Pannone, A. Santoro, S. Papagerakis, L. Lo Muzio, G. De Rosa, and P. Bufo The role of human papillomavirus in the pathogenesis of head and neck squamous cell carcinoma: an overview Infect Agents Cancer 6 2011 23
81. I. Chiba, M. Shindoh, M. Yasuda, Y. Yamazaki, A. Amemiya, and Y. Sato Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity Oncogene 12 1996 1663 1668
82. E.A. Sisk, C.R. Bradford, A. Jacob, C.H. Yian, K.M. Staton, and G. Tang Human papillomavirus infection in "young" vs. "old" patients with squamous cell carcinoma of the head and neck Head Neck 22 2000 649 657
83. S.R. Schwartz, B. Yueh, J.K. McDougall, J.R. Daling, and S.M. Schwartz Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study Otolaryngol Head Neck Surg 125 2001 1 9
84. S.E. Strome, A. Savva, A.E. Brissett, B.S. Gostout, J. Lewis, and A.C. Clayton Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations Clin Cancer Res 8 2002 1093 1100
85. B. Azzimonti, M. Pagano, M. Mondini, M. De Andrea, G. Valente, and G. Monga Altered patterns of the interferon-inducible gene IFI16 expression in head and neck squamous cell carcinoma: immunohistochemical study including correlation with retinoblastoma protein, human papillomavirus infection and proliferation index Histopathology 45 2004 560 572
86. G. Badaracco, C. Rizzo, B. Mafera, B. Pichi, D. Giannarelli, and S.S. Rahimi Molecular analyses and prognostic relevance of HPV in head and neck tumours Oncol Rep 17 2007 931 939
87. I.I. Na, H.J. Kang, S.Y. Cho, J.S. Koh, J.K. Lee, and B.C. Lee EGFR mutations and human papillomavirus in squamous cell carcinoma of tongue and tonsil Eur J Cancer 43 2007 520 526
88. M. Sugiyama, U.K. Bhawal, M. Kawamura, Y. Ishioka, H. Shigeishi, and K. Higashikawa Human papillomavirus-16 in oral squamous cell carcinoma: clinical correlates and 5-year survival Br J Oral Maxillofac Surg 45 2007 116 122
89. N. Reimers, H.U. Kasper, S.J. Weissenborn, H. Stutzer, S.F. Preuss, and T.K. Hoffmann Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer Int J Cancer 120 2007 1731 1738
90. J.A. Ernster, C.G. Sciotto, M.M. O'Brien, J.L. Finch, L.J. Robinson, and T. Willson Rising incidence of oropharyngeal cancer and the role of oncogenic human papilloma virus Laryngoscope 117 2007 2115 2128
91. C.J. Marsit, M.R. Posner, M.D. McClean, and K.T. Kelsey Hypermethylation of E-cadherin is an independent predictor of improved survival in head and neck squamous cell carcinoma Cancer 113 2008 1566 1571
92. C. Fakhry, W.H. Westra, S. Li, A. Cmelak, J.A. Ridge, and H. Pinto Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial J Natl Cancer Inst 100 2008 261 269
93. L. Charfi, T. Jouffroy, P. de Cremoux, N. Le Peltier, M. Thioux, and P. Freneaux Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome Cancer Lett 260 2008 72 78
94. J. Klozar, V. Kratochvil, M. Salakova, J. Smahelova, E. Vesela, and E. Hamsikova HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer Eur Arch Otorhinolaryngol 265 Suppl 1 2008 S75 82
95. C.Y. Chien, C.Y. Su, F.M. Fang, H.Y. Huang, H.C. Chuang, and C.M. Chen Lower prevalence but favorable survival for human papillomavirus-related squamous cell carcinoma of tonsil in Taiwan Oral Oncol 44 2008 174 179
96. E.M. Smith, D. Wang, L.M. Rubenstein, W.A. Morris, L.P. Turek, and T.H. Haugen Association between p53 and human papillomavirus in head and neck cancer survival Cancer Epidemiol Biomarkers Prev 17 2008 421 427
97. L. Alos, S. Moyano, A. Nadal, I. Alobid, J.L. Blanch, and E. Ayala Human papillomaviruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome Cancer 115 2009 2701 2709
98. W. Shi, H. Kato, B. Perez-Ordonez, M. Pintilie, S.H. Huang, and A. Hui Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma J Clin Oncol 27 2009 6213 6221
99. A.R. Sedaghat, Z. Zhang, S. Begum, R. Palermo, S. Best, and K.M. Ulmer Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas Laryngoscope 119 2009 1542 1549
100. S. Jo, A. Juhasz, K. Zhang, C. Ruel, S. Loera, and S.P. Wilczynski Human papillomavirus infection as a prognostic factor in oropharyngeal squamous cell carcinomas treated in a prospective phase II clinical trial Anticancer Res 29 2009 1467 1474
101. J.M. Straetmans, N. Olthof, J.J. Mooren, J. de Jong, E.J. Speel, and B. Kremer Human papillomavirus reduces the prognostic value of nodal involvement in tonsillar squamous cell carcinomas Laryngoscope 119 2009 1951 1957
102. J. Fei, A. Hong, T.A. Dobbins, D. Jones, C.S. Lee, and C. Loo Prognostic significance of vascular endothelial growth factor in squamous cell carcinomas of the tonsil in relation to human papillomavirus status and epidermal growth factor receptor Ann Surg Oncol 16 2009 2908 2917
103. A.C. Nichols, D.M. Finkelstein, W.C. Faquin, W.H. Westra, E.A. Mroz, and P. Kneuertz Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer Clin Cancer Res 16 2010 2138 2146
104. J.N. Al-Swiahb, C.C. Huang, F.M. Fang, H.C. Chuang, H.Y. Huang, and S.D. Luo Prognostic impact of p16, p53, epidermal growth factor receptor, and human papillomavirus in oropharyngeal cancer in a betel nut-chewing area Arch Otolaryngol Head Neck Surg 136 2010 502 508
105. A. Hong, T. Dobbins, C.S. Lee, D. Jones, E. Jackson, and J. Clark Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer Eur J Cancer 46 2010 2088 2096
106. P. Attner, J. Du, A. Nasman, L. Hammarstedt, T. Ramqvist, and J. Lindholm The role of human papillomavirus in the increased incidence of base of tongue cancer Int J Cancer 126 2010 2879 2884
107. H.Y. Lau, S. Brar, A.C. Klimowicz, S.K. Petrillo, D. Hao, and N.T. Brockton Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy Head Neck 33 2011 251 256
108. R.D. Chernock, Q. Zhang, S.K. El-Mofty, W.L. Thorstad, and J.S. Lewis Human papillomavirus-related squamous cell carcinoma of the oropharynx a comparative study in Whites and African Americans Arch Otolaryngol Head Neck Surg 137 2011 161 167