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Volumn 1, Issue , 2011, Pages 65-84

Enhanced Permeability and Retention Effect in Relation to Tumor Targeting

(1)  Maeda, Hiroshi a  

a NONE

Author keywords

Angiotensin induced hypertension; Difficult to treat cancer; EPR effect; Heterogeneity; Metastatic liver cancer; Nitric oxide; Permeability factor; SMANCS Lipiodol ; Tumor selective delivery

Indexed keywords


EID: 84869501324     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527634057.ch3     Document Type: Chapter
Times cited : (11)

References (57)
  • 1
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS
    • Matsumura, Y. and Maeda, H. (1986) A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res., 46, 6387-6392.
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 2
    • 0021211007 scopus 로고
    • Tailor-making of protein drugs by polymer conjugation for tumor targeting: a brief review on SMANCS
    • Maeda, H., Matsumoto, T., Konno, T., Iwai, K., and Ueda, M. (1984) Tailor-making of protein drugs by polymer conjugation for tumor targeting: a brief review on SMANCS. J. Protein Chem., 3, 181-193.
    • (1984) J. Protein Chem. , vol.3 , pp. 181-193
    • Maeda, H.1    Matsumoto, T.2    Konno, T.3    Iwai, K.4    Ueda, M.5
  • 3
    • 0013391194 scopus 로고
    • Calicheamicin antibody-drug conjugates and beyond in Protein Tailoring for Food and Medical Uses (eds R.E. Feeney and J.R. Whitaker)
    • Dekker, New York
    • Maeda, H., Matsumura, Y., Oda, T., and Sasamoto, K. (1986) Calicheamicin antibody-drug conjugates and beyond in Protein Tailoring for Food and Medical Uses (eds R.E. Feeney and J.R. Whitaker), Dekker, New York, pp. 353-382.
    • (1986) , pp. 353-382
    • Maeda, H.1    Matsumura, Y.2    Oda, T.3    Sasamoto, K.4
  • 4
    • 0024375781 scopus 로고
    • Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD
    • Oda, T., Akaike, T., Hamamoto, T., and Maeda, H. (1989) Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science, 244, 974-976.
    • (1989) Science , vol.244 , pp. 974-976
    • Oda, T.1    Akaike, T.2    Hamamoto, T.3    Maeda, H.4
  • 6
    • 0018889386 scopus 로고
    • Lymphotropic accumulation of an antitumor antibiotic protein, neocarzinostatin
    • Maeda, H., Takeshita, J., and Yamashita, A. (1980) Lymphotropic accumulation of an antitumor antibiotic protein, neocarzinostatin. Eur. J. Cancer, 16, 723-731.
    • (1980) Eur. J. Cancer , vol.16 , pp. 723-731
    • Maeda, H.1    Takeshita, J.2    Yamashita, A.3
  • 7
    • 0024839642 scopus 로고
    • Tumoritropic and lymphotropic principles of macromolecular drugs
    • Maeda, H., and Matsumura, Y. (1989) Tumoritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst., 6, 193-210.
    • (1989) Crit. Rev. Ther. Drug Carrier Syst. , vol.6 , pp. 193-210
    • Maeda, H.1    Matsumura, Y.2
  • 8
    • 0018634183 scopus 로고
    • Antimetastatic and antitumor activity of a derivative of neocarzinostatin: an organic solvent- and water-soluble polymer-conjugated protein
    • Maeda H., Takeshita, J., Kanamaru, R., Sato, H., Khatoh, J., and Sato, H. (1979) Antimetastatic and antitumor activity of a derivative of neocarzinostatin: an organic solvent- and water-soluble polymer-conjugated protein. Gann, 70, 601-606.
    • (1979) Gann , vol.70 , pp. 601-606
    • Maeda, H.1    Takeshita, J.2    Kanamaru, R.3    Sato, H.4    Khatoh, J.5    Sato, H.6
  • 9
    • 0019948596 scopus 로고
    • In vitro mode of action, pharmacokinetics, and organ specificity of poly(maleic acid-styrene)-conjugated neocarzinostatin, SMANCS
    • Takeshita, J., Maeda, H., and Kanamaru, R. (1982) In vitro mode of action, pharmacokinetics, and organ specificity of poly(maleic acid-styrene)-conjugated neocarzinostatin, SMANCS. Gann, 73, 278-284.
    • (1982) Gann , vol.73 , pp. 278-284
    • Takeshita, J.1    Maeda, H.2    Kanamaru, R.3
  • 10
    • 0018287715 scopus 로고
    • A lipophilic derivative of neocarzinostatin: a polymer conjugation of an antitumor protein antibiotic
    • Maeda, H., Takeshita, J., and Kanamaru, R. (1979) A lipophilic derivative of neocarzinostatin: a polymer conjugation of an antitumor protein antibiotic. Int. J. Pept. Protein Res., 14, 81-87.
    • (1979) Int. J. Pept. Protein Res. , vol.14 , pp. 81-87
    • Maeda, H.1    Takeshita, J.2    Kanamaru, R.3
  • 11
    • 0031959490 scopus 로고    scopus 로고
    • Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues
    • Noguchi, Y., Wu, J., Duncan, R., Strohalm, J., Ulbrich, K., Akaike, T., and Maeda, H. (1998) Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res., 89, 307-314.
    • (1998) Jpn. J. Cancer Res. , vol.89 , pp. 307-314
    • Noguchi, Y.1    Wu, J.2    Duncan, R.3    Strohalm, J.4    Ulbrich, K.5    Akaike, T.6    Maeda, H.7
  • 12
    • 0029039418 scopus 로고
    • Influence of molecular weight on passive tumour accumulation of a soluble macromolecular durg carrier
    • Seymour, L.W., Miyamoto, Y., Maeda, H., Brereton, M., Strohalm, J., Ulbrich, K., and Duncan, R. (1995) Influence of molecular weight on passive tumour accumulation of a soluble macromolecular durg carrier. Eur. J. Cancer, 31, 766-770.
    • (1995) Eur. J. Cancer , vol.31 , pp. 766-770
    • Seymour, L.W.1    Miyamoto, Y.2    Maeda, H.3    Brereton, M.4    Strohalm, J.5    Ulbrich, K.6    Duncan, R.7
  • 13
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics
    • Maeda, H., Wu, J., Sawa, T., Matsumura, Y., and Hori, K. (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics. J. Control. Release, 65, 271-284.
    • (2000) J. Control. Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 14
    • 0026118760 scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
    • Maeda, H. (1991) SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Deliv. Rev., 6, 181-202.
    • (1991) Adv. Drug Deliv. Rev. , vol.6 , pp. 181-202
    • Maeda, H.1
  • 15
    • 0035816204 scopus 로고    scopus 로고
    • Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS
    • Maeda, H., Sawa, T., and Konno, T. (2001) Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J. Control. Release, 74, 47-61.
    • (2001) J. Control. Release , vol.74 , pp. 47-61
    • Maeda, H.1    Sawa, T.2    Konno, T.3
  • 16
    • 79953054576 scopus 로고    scopus 로고
    • EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitation and augmentation of the effect
    • Fang, J., Nakamura, H., and Maeda, H. (2010) EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitation and augmentation of the effect. Adv. Drug Deliv. Rev., 63, 136-151.
    • (2010) Adv. Drug Deliv. Rev. , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 17
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting, Adv
    • Maeda, H. (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting, Adv. Enzyme Regul., 41, 189-207.
    • (2001) Enzyme Regul. , vol.41 , pp. 189-207
    • Maeda, H.1
  • 18
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects
    • Maeda, H. (2010) Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug. Chem., 21, 797-802.
    • (2010) Bioconjug. Chem. , vol.21 , pp. 797-802
    • Maeda, H.1
  • 19
    • 0028227005 scopus 로고
    • Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor
    • Maeda, H., Noguchi, Y., Sato, K., and Akaike, T. (1994) Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn. J. Cancer Res., 85, 331-334.
    • (1994) Jpn. J. Cancer Res. , vol.85 , pp. 331-334
    • Maeda, H.1    Noguchi, Y.2    Sato, K.3    Akaike, T.4
  • 20
    • 0031964923 scopus 로고    scopus 로고
    • Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger
    • Wu, J., Akaike, T., and Maeda, H. (1998) Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. Cancer Res., 58, 159-165.
    • (1998) Cancer Res. , vol.58 , pp. 159-165
    • Wu, J.1    Akaike, T.2    Maeda, H.3
  • 21
    • 0023821387 scopus 로고
    • Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer
    • Maeda, H., Matsumura, Y., and Kato, H. (1988) Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer. J. Biol. Chem., 263, 16051-16054.
    • (1988) J. Biol. Chem. , vol.263 , pp. 16051-16054
    • Maeda, H.1    Matsumura, Y.2    Kato, H.3
  • 22
    • 0029551759 scopus 로고
    • Microvascular corrosion casting in the study of tumor vascularity: a review
    • Konerding, M.A., Miodonski, A.J., and Lametschwandtner, A. (1995) Microvascular corrosion casting in the study of tumor vascularity: a review. Scanning Microsc., 9, 1233-1244.
    • (1995) Scanning Microsc. , vol.9 , pp. 1233-1244
    • Konerding, M.A.1    Miodonski, A.J.2    Lametschwandtner, A.3
  • 24
    • 0021349643 scopus 로고
    • Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image
    • Iwai, K., Maeda, H., and Konno, T. (1984) Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image. Cancer Res., 44, 2115-2121.
    • (1984) Cancer Res. , vol.44 , pp. 2115-2121
    • Iwai, K.1    Maeda, H.2    Konno, T.3
  • 25
    • 0021687244 scopus 로고
    • Selective targeting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium
    • Konno, T., Maeda, H., Iwai, K., Maki, S., Tashiro, S., Uchida, M., and Miyauchi, Y. (1984) Selective targeting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer, 54, 2367-2374.
    • (1984) Cancer , vol.54 , pp. 2367-2374
    • Konno, T.1    Maeda, H.2    Iwai, K.3    Maki, S.4    Tashiro, S.5    Uchida, M.6    Miyauchi, Y.7
  • 26
    • 0021968171 scopus 로고
    • Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium
    • Maki, S., Konno, T., and Maeda, H. (1985) Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium. Cancer, 56, 751-757.
    • (1985) Cancer , vol.56 , pp. 751-757
    • Maki, S.1    Konno, T.2    Maeda, H.3
  • 27
    • 70449374917 scopus 로고    scopus 로고
    • Elevating blood pressure as a strategy to increase tumor targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors
    • Nagamitsu, A., Greish, K., and Maeda, H. (2009) Elevating blood pressure as a strategy to increase tumor targeted delivery of macromolecular drug SMANCS: cases of advanced solid tumors. Jpn. J. Clin. Oncol., 39, 756-766.
    • (2009) Jpn. J. Clin. Oncol. , vol.39 , pp. 756-766
    • Nagamitsu, A.1    Greish, K.2    Maeda, H.3
  • 28
    • 0021168136 scopus 로고
    • Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease
    • Matsumoto, K., Yamamoto, T., Kamata, R., and Maeda, H. (1984) Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. J. Biochem., 96, 739-749.
    • (1984) J. Biochem. , vol.96 , pp. 739-749
    • Matsumoto, K.1    Yamamoto, T.2    Kamata, R.3    Maeda, H.4
  • 31
    • 0027305768 scopus 로고
    • EPR effect of microbial and mita protease on low and high molecular weight kininogen
    • Maruo, K., Akaike, T., Inada, Y., Ohkubo, I., Ono, T., and Maeda, H. (1993) EPR effect of microbial and mita protease on low and high molecular weight kininogen. J. Biol. Chem., 268, 17711-17715.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17711-17715
    • Maruo, K.1    Akaike, T.2    Inada, Y.3    Ohkubo, I.4    Ono, T.5    Maeda, H.6
  • 32
    • 0024151625 scopus 로고
    • Involvement of the kinin-generating cascade and enhanced vascular permeability in tumor tissue
    • Matsumura, Y., Kimura, M., Yamamoto, T., and Maeda, H. (1988) Involvement of the kinin-generating cascade and enhanced vascular permeability in tumor tissue. Jpn. J. Cancer Res., 79, 1327-1334.
    • (1988) Jpn. J. Cancer Res. , vol.79 , pp. 1327-1334
    • Matsumura, Y.1    Kimura, M.2    Yamamoto, T.3    Maeda, H.4
  • 33
    • 0035001708 scopus 로고    scopus 로고
    • Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinase
    • Wu, J., Akaike, T., Hayashida, K., Okamoto, T., Okuyama, A., and Maeda, H. (2001) Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinase. Jpn. J. Cancer Res., 92, 439-451.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 439-451
    • Wu, J.1    Akaike, T.2    Hayashida, K.3    Okamoto, T.4    Okuyama, A.5    Maeda, H.6
  • 34
    • 0034693229 scopus 로고    scopus 로고
    • Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase
    • Sawa, T., Akaike, T., and Maeda, H. (2000) Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase. J. Biol. Chem., 275, 32467-32474.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32467-32474
    • Sawa, T.1    Akaike, T.2    Maeda, H.3
  • 36
    • 0032775521 scopus 로고    scopus 로고
    • Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH
    • Maeda, H., Sawa, T., Yubisui, T., and Akaike, T. (1999) Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH. Cancer Lett., 143, 117-121.
    • (1999) Cancer Lett. , vol.143 , pp. 117-121
    • Maeda, H.1    Sawa, T.2    Yubisui, T.3    Akaike, T.4
  • 38
    • 77954837315 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of tumor targeting SMA-pirarubicin micelles: survival improvement and inhibition of liver metastases
    • Daruwalla, J., Nikfarjam, M., Greish, K., Malcontenti-WilsonI, C., Muralidharan, V., Christophe, C., and Maeda, H. (2010) In vitro and in vivo evaluation of tumor targeting SMA-pirarubicin micelles: survival improvement and inhibition of liver metastases. Cancer Sci., 101, 1866-1874.
    • (2010) Cancer Sci. , vol.101 , pp. 1866-1874
    • Daruwalla, J.1    Nikfarjam, M.2    Greish, K.3    Malcontenti-WilsonI, C.4    Muralidharan, V.5    Christophe, C.6    Maeda, H.7
  • 39
    • 0021192280 scopus 로고
    • Functional characterization of the microcirculation in tumors
    • Suzuki, M., Hori, H., Abe, I., Saito, S., and Sato, H. (1984) Functional characterization of the microcirculation in tumors. Cancer Metastasis Rev., 3, 115-126.
    • (1984) Cancer Metastasis Rev. , vol.3 , pp. 115-126
    • Suzuki, M.1    Hori, H.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 40
    • 0019478990 scopus 로고
    • A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II
    • Suzuki, M., Hori, K., Abe, I., Saito, S., and Sato, H. (1981) A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II. J. Natl. Cancer Inst., 67, 663-669.
    • (1981) J. Natl. Cancer Inst. , vol.67 , pp. 663-669
    • Suzuki, M.1    Hori, K.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 41
    • 0027299899 scopus 로고
    • Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure
    • Li, C.J., Miyamoto, Y., Kojima, Y., and Maeda, H. (1993) Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure. Br. J. Cancer, 67, 975-980.
    • (1993) Br. J. Cancer , vol.67 , pp. 975-980
    • Li, C.J.1    Miyamoto, Y.2    Kojima, Y.3    Maeda, H.4
  • 42
    • 70649088695 scopus 로고    scopus 로고
    • Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
    • Seki, T., Fang, J., and Maeda, H. (2009) Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application. Cancer Sci., 100, 2426-2430.
    • (2009) Cancer Sci. , vol.100 , pp. 2426-2430
    • Seki, T.1    Fang, J.2    Maeda, H.3
  • 43
    • 77349118467 scopus 로고    scopus 로고
    • Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: analogy between angina pectoris and solid tumors and enhancement of the EPR effect
    • Maeda, H. (2010) Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: analogy between angina pectoris and solid tumors and enhancement of the EPR effect. J. Control. Release, 142, 296-298.
    • (2010) J. Control. Release , vol.142 , pp. 296-298
    • Maeda, H.1
  • 46
    • 70349466391 scopus 로고    scopus 로고
    • Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer
    • Siemens, D.R., Heaton, J., Adams, M., Kawakami, J., and Graham, C. (2009) Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer. Urology, 74, 878-883.
    • (2009) Urology , vol.74 , pp. 878-883
    • Siemens, D.R.1    Heaton, J.2    Adams, M.3    Kawakami, J.4    Graham, C.5
  • 48
    • 0037732561 scopus 로고    scopus 로고
    • Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin I2 analogue beraprost sodium
    • Tanaka, S., Akaike, T., Wu, J., Fang, J., Sawa, T., Ogawa, M., Beppu, T., and Maeda, H. (2003) Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin I2 analogue beraprost sodium. J. Drug Target., 11, 45-52.
    • (2003) J. Drug Target. , vol.11 , pp. 45-52
    • Tanaka, S.1    Akaike, T.2    Wu, J.3    Fang, J.4    Sawa, T.5    Ogawa, M.6    Beppu, T.7    Maeda, H.8
  • 50
    • 0032778341 scopus 로고    scopus 로고
    • Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
    • Doi, K., Akaike, T., Fujii, S., Horie, H., Noguchi, Y., Fujii, S., Beppu, T., Ogawa, M., and Maeda, H. (1999) Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth. Br. J. Cancer, 80, 1945-1954.
    • (1999) Br. J. Cancer , vol.80 , pp. 1945-1954
    • Doi, K.1    Akaike, T.2    Fujii, S.3    Horie, H.4    Noguchi, Y.5    Fujii, S.6    Beppu, T.7    Ogawa, M.8    Maeda, H.9
  • 51
    • 0036606394 scopus 로고    scopus 로고
    • Tumor-targeted delivery of polyethylene glycol-conjugated d-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide
    • Fang, J., Sawa, T., Akaike, T., and Maeda, H. (2002) Tumor-targeted delivery of polyethylene glycol-conjugated d-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer Res., 62, 3138-3143.
    • (2002) Cancer Res. , vol.62 , pp. 3138-3143
    • Fang, J.1    Sawa, T.2    Akaike, T.3    Maeda, H.4
  • 52
    • 0038418359 scopus 로고    scopus 로고
    • In vivo, antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor
    • Fang, J., Sawa, T., Akaike, T., Akuta, T., Greish, K., Hamada, A., and Maeda, H. (2003) In vivo, antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res., 63, 3567-3574.
    • (2003) Cancer Res. , vol.63 , pp. 3567-3574
    • Fang, J.1    Sawa, T.2    Akaike, T.3    Akuta, T.4    Greish, K.5    Hamada, A.6    Maeda, H.7
  • 53
    • 79953066932 scopus 로고    scopus 로고
    • A multifunctional envelope type nano device (MEND) for drug and gene delivery to tumors based on the EPR effect: a strategy for overcoming the PEG dilemma
    • Hatakeyama, H., Akita, H., and Harashima, H. (2011) A multifunctional envelope type nano device (MEND) for drug and gene delivery to tumors based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv. Drug. Deliv. Rev., 63, 152-160.
    • (2011) Adv. Drug. Deliv. Rev. , vol.63 , pp. 152-160
    • Hatakeyama, H.1    Akita, H.2    Harashima, H.3
  • 54
    • 70349103682 scopus 로고    scopus 로고
    • Proteolysis: a biological process adapted in drug delivery therapy, and imaging
    • Law, B., and Tung, C.H. (2009) Proteolysis: a biological process adapted in drug delivery, therapy, and imaging. Bioconjug. Chem., 20, 1683-1695.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 1683-1695
    • Law, B.1    Tung, C.H.2
  • 56
    • 80054695837 scopus 로고    scopus 로고
    • Intracellular uptake and behaviour of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; Unique intracellular disintegration of SMA micelles
    • in press
    • Nakamura, H., Fang, J., Bharate, G., Tsukigawa, K., and Maeda, H. (2011) Intracellular uptake and behaviour of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; Unique intracellular disintegration of SMA micelles. J. Control. Release, in press.
    • (2011) J. Control. Release
    • Nakamura, H.1    Fang, J.2    Bharate, G.3    Tsukigawa, K.4    Maeda, H.5
  • 57
    • 33645815708 scopus 로고    scopus 로고
    • Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes
    • Ishida, T., Ichihara, M., Wang, X.Y., Yamamoto, K., Kimura, J., Majima, E., and Kiwada, H. (2006) Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J. Control. Release, 112, 15-25.
    • (2006) J. Control. Release , vol.112 , pp. 15-25
    • Ishida, T.1    Ichihara, M.2    Wang, X.Y.3    Yamamoto, K.4    Kimura, J.5    Majima, E.6    Kiwada, H.7


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