Antibacterial activity of LCB01-0062, a novel oxazolidinone

International Journal of Antimicrobial Agents

Volumn 40, Issue 6, 2012, Pages 539-543

  Jung, Sung Ji ^a   Yun, I Na Rae ^a   Park, Hee Soo ^a,b   Lee, Hyun Hee ^a   Jeong, Ji Woong ^a   Kim, Yong Zu ^c   Cho, Young Lak ^c   Kwak, Jin Hwan ^a  

^a Handong University   (South Korea)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c LegoChem Biosciences Inc   (South Korea)

Author keywords

LCB01 0062; MIC; Oxazolidinone; Systemic infection; Time kill

Indexed keywords

CIPROFLOXACIN; DALFOPRISTIN; ERYTHROMYCIN; LCB 01 0062; LINEZOLID; OXACILLIN; OXAZOLIDINONE DERIVATIVE; QUINUPRISTIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIOSTASIS; BACTERIUM ISOLATE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG POTENCY; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT COAGULASE NEGATIVE STAPHYLOCOCCUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS INFECTION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; COLONY COUNT, MICROBIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; MOLECULAR STRUCTURE; OXAZOLIDINONES; TIME FACTORS;

EID: 84869500947     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.07.017     Document Type: Article

References (13)

1. S.B. Levy, and B. Marshall Antibacterial resistance worldwide: causes, challenges and responses Nat Med 10 12 Suppl. 2004 s122 s129
2. D.M. Livermore The need for new antibiotics Clin Microbiol Infect 10 2004 1 9
3. D.J. Diekema, and R.N. Jones Oxazolidinone antibiotics Lancet 358 2001 1975 1982 (Pubitemid 34072884)
4. D.N. Wilson, F. Schluenzen, J.M. Harms, A.L. Starosta, S.R. Connell, and P. Fucini The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning Proc Natl Acad Sci USA 105 2008 13339 13344
5. J.A. Ippolito, Z.F. Kanyo, D. Wang, F.J. Franceschi, P.B. Moore, and T.A. Steitz Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit J Med Chem 51 2008 3353 3356 (Pubitemid 351874992)
6. H.M. Babcock, D.J. Ritchie, E. Christiansen, R. Starlin, R. Little, and S. Stanley Successful treatment of vancomycin-resistant Enterococcus endocarditis with oral linezolid Clin Infect Dis 32 2001 1373 1375 (Pubitemid 32405913)
7. Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically; approved standards. 9th ed. Document M07-A9. Wayne, PA: CLSI; 2012.
8. Clinical and Laboratory Standards Institute. Methods for determining bactericidal activity of antimicrobial agents: approved guideline. Document M26-A. Wayne, PA: CLSI; 1999.
9. C.I. Bliss Statistics in bioassay 1985 Academic Press, Inc. New York, NY
10. M.H. Scheetz, S.A. Knechtel, M. Malczynski, M.J. Postelnick, and C. Qi Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption Antimicrob Agents Chemother 52 2008 2256 2259 (Pubitemid 351758573)
11. E.I. Metaxas, and M.E. Falagas Update on the safety of linezolid Expert Opin Drug Saf 8 2009 485 491
12. R.C. Moellering Jr. Discovering new antimicrobial agents Int J Antimicrob Agents 37 2011 2 9
13. R. Schaadt, D. Sweeney, D. Shinabarger, and G. Zurenko In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent Antimicrob Agents Chemother 53 2009 3236 3239