Surgical treatment of bisphosphonate-associated osteonecrosis of the jaw: Technical report and follow up of 21 patients

Journal of Cranio-Maxillofacial Surgery

Volumn 40, Issue 8, 2012, Pages 719-725

  Voss, Pit Jacob ^a   Joshi Oshero, Joel ^a   Kovalova Müller, Alice ^a   Veigel Merino, Egle Alina ^a   Sauerbier, Sebastian ^a   Al Jamali, Jamil ^a   Lemound, Juliana ^a   Metzger, Marc Christian ^a   Schmelzeisen, Rainer ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Bisphosphonate; Jaw; Necrosis; surgical treatment

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CHLORHEXIDINE; CLINDAMYCIN; METRONIDAZOLE; PENICILLIN G;

ADULT; AGE; AGED; ANTIBIOTIC THERAPY; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CURETTAGE; DEBRIDEMENT; FEMALE; FISTULA; FOLLOW UP; GENDER; HUMAN; JAW OSTEONECROSIS; KIDNEY CARCINOMA; MALE; PLASMACYTOMA; PROSTATE CARCINOMA; RECURRENT DISEASE; RETROSPECTIVE STUDY; TREATMENT DURATION; TREATMENT OUTCOME; VULVA CARCINOMA; WOUND CLOSURE; WOUND DEHISCENCE;

AGED; AGED, 80 AND OVER; ALENDRONATE; BISPHOSPHONATE-ASSOCIATED OSTEONECROSIS OF THE JAW; BONE DENSITY CONSERVATION AGENTS; DEBRIDEMENT; DENTAL CARE; DIPHOSPHONATES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMIDAZOLES; MALE; MANDIBULAR DISEASES; MIDDLE AGED; ORAL FISTULA; OSTEOTOMY; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; SURGICAL FLAPS; SURGICAL WOUND DEHISCENCE; SUTURE TECHNIQUES; TREATMENT OUTCOME;

EID: 84869491559     PISSN: 10105182     EISSN: 18784119     Source Type: Journal    
DOI: 10.1016/j.jcms.2012.01.005     Document Type: Article

References (59)

1. M.H. Abu-Id, P.H. Warnke, J. Gottschalk, I. Springer, J. Wiltfang, and Y. Acil "Bis-phossy jaws" - high and low risk factors for bisphosphonate-induced osteonecrosis of the jaw J Craniomaxillofac Surg 36 2 2008 95 103
2. A. Agrillo, M.T. Petrucci, M. Tedaldi, M.C. Mustazza, S.M. Marino, and C. Gallucci New therapeutic protocol in the treatment of avascular necrosis of the jaws J Craniofac Surg 17 6 2006 1080 1083
3. M.R. Allen, and D.B. Burr The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data J Oral Maxillofac Surg 67 5 Suppl. 2009 61 70
4. B. Al-Nawas, K.A. Grötz, and J.U. Piesold Leitliniengruppe "Septische Chirurgie" der DGMKG. Bisphosphonat-assoziierte Kiefernekrose AWMF-Leitlinien-Register Nr. 007/091. Available at: http://www.awmf.org/uploads/tx-szleitlinien/007-091l-S1-Bisphosphonat- assoziierte-Kiefernekrosen.pdf (accessed 14.09.07)
5. T. Boonyapakorn, I. Schirmer, P.A. Reichart, I. Sturm, and G. Massenkeil Bisphosphonate-induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies Oral Oncol 44 9 2008 857 869
6. E.R. Carlson, and J.D. Basile The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws J Oral Maxillofac Surg 67 5 Suppl. 2009 85 95
7. G.A. Clines, and T.A. Guise Mechanisms and treatment for bone metastases Clin Adv Hematol Oncol 2 5 2004 295 302
8. I.J. Diel, A. Jaschke, E.F. Solomayer, C. Gollan, G. Bastert, and C. Sohn Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up Ann Oncol 19 12 2008 2007 2011
9. R.B. Dixon, N.D. Tricker, and L.P. Garetto Bone turnover in elderly canine mandible and tibia J Dent Res 76 Suppl. 1 2007 336
10. B.G. Durie, M. Katz, and J. Crowley Osteonecrosis of the jaw and bisphosphonates N Engl J Med 353 1 2005 99 102
11. F.H. Ebetino, A.M. Hogan, S. Sun, M.K. Tsoumpra, X. Duan, and J.T. Triffitt The relationship between the chemistry and biological activity of the bisphosphonates Bone 49 1 2011 20 33
12. S. Elad, N. Yarom, W. Hamed, S. Ayalon, R. Yahalom, and E. Regev Osteomyelitis and necrosis of the jaw in patients treated with bisphosphonates: a comparative study focused on multiple myeloma Clin Lab Haematol 28 6 2006 393 398
13. S. Ferrari, B. Bianchi, A. Savi, T. Poli, A. Multinu, and A. Balestreri Fibula free flap with endosseous implants for reconstructing a resected mandible in bisphosphonate osteonecrosis J Oral Maxillofac Surg 66 5 2008 999 1003
14. K.E. Fleisher, S. Doty, S. Kottal, J. Phelan, R.G. Norman, and R.S. Glickman Tetracycline-guided debridement and cone beam computed tomography for the treatment of bisphosphonate-related osteonecrosis of the jaw: a technical note J Oral Maxillofac Surg 66 12 2008 2646 2653
15. P. Fournier, S. Boissier, S. Filleur, J. Guglielmi, F. Cabon, and M. Colombel Bisphosphonates inhibit angiogenesis in vitro and testosterone- stimulated vascular regrowth in the ventral prostate in castrated rats Cancer Res 62 22 2002 6538 6544
16. J.J. Freiberger, R. Padilla-Burgos, A.H. Chhoeu, K.H. Kraft, O. Boneta, and R.E. Moon Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series J Oral Maxillofac Surg 65 7 2007 1321 1327
17. D.R. Guay Ibandronate: a new oral bisphosphonate for postmenopausal osteoporosis Consult Pharm 20 12 2005 1036 1055
18. L.M. Hess, J.M. Jeter, M. Benham-Hutchins, and D.S. Alberts Factors associated with osteonecrosis of the jaw among bisphosphonate users Am J Med 121 6 2008 475 483
19. S. Hoefert, and H. Eufinger Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw J Oral Maxillofac Surg 69 2 2011 362 380
20. A.O. Hoff, B.B. Toth, K. Altundag, M.M. Johnson, C.L. Warneke, and M. Hu Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates J Bone Miner Res 23 6 2008 826 836
21. A.A. Khan, G.K. Sándor, E. Dore, A.D. Morrison, M. Alsahli, and F. Amin Canadian Association of Oral and Maxillofacial Surgeons. Canadian consensus practice guidelines for bisphosphonate associated osteonecrosis of the jaw J Rheumatol 35 7 2008 1391 1397
22. D.B. Kimmel Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates J Dent Res 86 11 2007 1022 1033
23. K.C. Lasseter, A.G. Porras, A. Denker, A. Santhanagopal, and A. Daifotis Pharmacokinetic considerations in determining the terminal elimination half-lives of bisphosphonates Clin Drug Investig 25 2 2005 107 114
24. T.S. Lazarovici, R. Yahalom, S. Taicher, S. Elad, I. Hardan, and N. Yarom Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients J Oral Maxillofac Surg 67 4 2009 850 855
25. J. Lemound, A. Eckardt, H. Kokemüller, C. von See, P.J. Voss, and F. Tavassol Bisphosphonate-associated osteonecrosis of the mandible: reliable soft tissue reconstruction using a local myofascial flap Clin Oral Investig 2011 Aug 5 [Epub ahead of print]
26. J.C. Lo, F.S. O'Ryan, N.P. Gordon, J. Yang, R.L. Hui, and D. Martin Predicting Risk of Osteonecrosis of the Jaw with Oral Bisphosphonate Exposure (PROBE) Investigators. Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure J Oral Maxillofac Surg 68 2 2010 243 253
27. G. Lodi, A. Sardella, A. Salis, F. Demarosi, M. Tarozzi, and A. Carrassi Tooth extraction in patients taking intravenous bisphosphonates: a preventive protocol and case series J Oral Maxillofac Surg 68 1 2010 107 110
28. M. Loubele, M.E. Guerrero, R. Jacobs, P. Suetens, and D. van Steenberghe A comparison of jaw dimensional and quality assessments of bone characteristics with cone-beam CT, spiral tomography, and multi-slice spiral CT Int J Oral Maxillofac Implants 22 3 2007 446 454
29. C. Magopoulos, G. Karakinaris, Z. Telioudis, K. Vahtsevanos, I. Dimitrakopoulos, and K. Antoniadis Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals Am J Otol 28 3 2007 158 163
30. T. Mashiba, C.H. Turner, T. Hirano, M.R. Forwood, C.C. Johnston, and D.B. Burr Effects of suppresses bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles Bone 28 5 2001 524 531
31. G. Markose, F.R. Mackenzie, W.J. Currie, and W.S. Hislop Bisphosphonate osteonecrosis: a protocol for surgical management Br J Oral Maxillofac Surg 47 4 2009 Jun 294 297
32. R.E. Marx Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic J Oral Maxillofac Surg 61 9 2003 1115 1117
33. R.E. Marx Reconstruction of defects caused by bisphosphonate-induced osteonecrosis of the jaws J Oral Maxillofac Surg 67 5 Suppl. 2009 107 119
34. N.M. McLeod, V. Patel, A. Kusanale, S.N. Rogers, and P.A. Brennan Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw Br J Oral Maxillofac Surg 49 5 2011 335 342
35. L. Montebugnoli, L. Felicetti, D.B. Gissi, A. Pizzigallo, G.A. Pelliccioni, and C. Marchetti Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104 4 2007 473 477
36. T. Mücke, S. Haarmann, K.D. Wolff, and F. Hölzle Bisphosphonate related osteonecrosis of the jaws treated by surgical resection and immediate osseous microvascular reconstruction J Craniomaxillofac Surg 37 5 2009 291 297
37. S. Otto, S. Hafner, G. Mast, T. Tischer, E. Volkmer, and M. Schieker Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle? J Oral Maxillofac Surg 68 5 2010 1158 1161
38. S. Otto, C. Schreyer, S. Hafner, G. Mast, M. Ehrenfeld, and S. Stürzenbaum Bisphosphonate-related osteonecrosis of the jaws - Characteristics, risk factors, clinical features, localization and impact on oncological treatment J Craniomaxillofac Surg 2011 Jun 13 [Epub ahead of print]
39. C. Pautke, F. Bauer, T. Tischer, K. Kreutzer, J. Weitz, and M. Kesting Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws J Oral Maxillofac Surg 67 3 2009 471 476
40. C. Pautke, F. Bauer, S. Otto, T. Tischer, T. Steiner, and J. Weitz Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: first clinical results of a prospective pilot study J Oral Maxillofac Surg 69 1 2011 84 91
41. F.A. Pickett Bisphosphonate-associated osteonecrosis of the jaw: a literature review and clinical practice guidelines J Dent Hyg 80 3 2006 10
42. S.L. Ruggiero, and S.J. Drew Osteonecrosis of the jaws and bisphosphonate therapy J Dent Res 86 11 2007 1013 1021
43. S.L. Ruggiero, B. Mehrotra, T.J. Rosenberg, and S.L. Engroff Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases J Oral Maxillofac Surg 62 5 2004 527 534
44. S.L. Ruggiero, J. Fantasia, and E. Carlson Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 4 2006 433 441
45. S.L. Ruggiero, T.B. Dodson, L.A. Assael, R. Landesberg, R.E. Marx, and B. Mehrotra Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw - 2009 update Aust Endod J 35 3 2009 119 130
46. W.K. Sietsema, F.H. Ebetino, A.M. Salvagno, and J.A. Bevan Antiresorptive dose-response relationships across three generations of bisphosphonates Drugs Exp Clin Res 15 9 1989 389 396
47. D.C. Stanton, and E. Balasanian Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases J Oral Maxillofac Surg 67 5 2009 943 950
48. P. Stockmann, E. Vairaktaris, F. Wehrhan, M. Seiss, S. Schwarz, and B. Spriewald Osteotomy and primary wound closure in bisphosphonate-associated osteonecrosis of the jaw: a prospective clinical study with 12 months follow-up Support Care Cancer 18 4 2010 449 460
49. A. Triaca, R. Minoretti, M. Merli, and B. Merz Periosteoplasty for soft tissue closure and augmentation in preprosthetic surgery: a surgical report Int J Oral Maxillofac Implants 16 6 2001 851 856
50. T. Van den Wyngaert, M.T. Huizing, and J.B. Vermorken Osteonecrosis of the jaw related to the use of bisphosphonates Curr Opin Oncol 19 4 2007 315 322
51. P. Vescovi, E. Merigo, M. Manfredi, M. Meleti, C. Fornaini, and M. Bonanini Nd:YAG laser biostimulation in the treatment of bisphosphonate- associated osteonecrosis of the jaw: clinical experience in 28 cases Photomed Laser Surg 26 1 2008 37 46
52. P. Vescovi, M. Manfredi, E. Merigo, M. Meleti, C. Fornaini, and J.P. Rocca Surgical approach with Er:YAG laser on osteonecrosis of the jaws (ONJ) in patients under bisphosphonate therapy (BPT) Lasers Med Sci 25 1 2010 101 113
53. C. Walter, B. Al-Nawas, K.A. Grötz, C. Thomas, J.W. Thüroff, and V. Zinser Prevalence and risk factors of bisphosphonate-associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate Eur Urol 54 5 2008 1066 1072
54. C. Walter, B. Al-Nawas, N. Frickhofen, H. Gamm, J. Beck, and L. Reinsch Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients Head Face Med 8 6 2010 11
55. E.P. Wang, L.B. Kaban, G.J. Strewler, N. Raje, and M.J. Troulis Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy J Oral Maxillofac Surg 65 7 2007 1328 1331
56. D. Wen, L. Qing, G. Harrison, E. Golub, and S.O. Akintoye Anatomic site variability in rat skeletal uptake and desorption of fluorescently labeled bisphosphonate Oral Dis 17 2011 427 432
57. F. Wilde, M. Heufelder, K. Winter, J. Hendricks, B. Frerich, and A. Schramm The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111 2 2011 153 163
58. R.A. Williamson Surgical management of bisphosphonate induced osteonecrosis of the jaws Int J Oral Maxillofac Surg 39 3 2010 251 255
59. A. Wutzl, E. Biedermann, F. Wanschitz, R. Seemann, C. Klug, and A. Baumann Treatment results of bisphosphonate-related osteonecrosis of the jaws Head Neck 30 9 2008 1224 1230