DRUG ACCUMULATION;
DRUG DELIVERY SYSTEM;
DRUG EFFICACY;
DRUG FORMULATION;
DRUG PENETRATION;
DRUG RETENTION;
DRUG SAFETY;
DRUG SOLUBILITY;
DRUG STABILITY;
HUMAN;
HYDROPHILICITY;
KIDNEY FUNCTION;
LIPOSOMAL DELIVERY;
LIVER FUNCTION;
LIVER TOXICITY;
NANOPHARMACEUTICS;
NEPHROTOXICITY;
NONHUMAN;
PRIORITY JOURNAL;
REVIEW;
ANTINEOPLASTIC AGENTS;
DRUG CARRIERS;
HUMANS;
NANOPARTICLES;
NEOPLASMS;
TISSUE DISTRIBUTION;
Early cessation of the clinical development of LiPlaCis, a liposomal cisplatin formulation
De Jonge MJ, Slingerland M, Loos WJ et al. Early cessation of the clinical development of LiPlaCis, a liposomal cisplatin formulation. Eur. J. Cancer 46(16), 3016-3021 (2010).
Sengupta P, Basu S, Soni S et al. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity. Proc. Natl Acad. Sci. USA 109(28), 11294-11299 (2012).
Reduced cardiotoxicity and comparable efficacy in a Phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
O'Brien ME, Wigler N, Inbar M et al. Reduced cardiotoxicity and comparable efficacy in a Phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann. Oncol. 15(3), 440-449 (2004).
Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy
Werner ME, Copp JA, Karve S et al. Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy. ACS Nano 5(11), 8990-8998 (2011).
Drugging the PI3 kinome: From chemical tools to drugs in the clinic
Workman P, Clarke PA, Raynaud FI, Van Montfort RL. Drugging the PI3 kinome: From chemical tools to drugs in the clinic. Cancer Res. 70(6), 2146-2157 (2010).
Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery
Karve S, Werner ME, Sukumar R et al. Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery. Proc. Natl Acad. Sci. USA 109(21), 8230-8235 (2012).
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Davis ME, Zuckerman JE, Choi CH et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464(7291), 1067-1070 (2010).