Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells

Autophagy

Volumn 8, Issue 11, 2012, Pages 1677-1679

  Luo, Zhongguang ^a,b   Pan, Yongfu ^a   Jeong, Lak Shin ^c   Liu, Jie ^a,b   Jia, Lijun ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c Ewha Womans University   (South Korea)

Author keywords

Autophagy; Cullin RING E3 ligase; DEPTOR; MLN4924; MTOR; NEDD8 activating enzyme; Neddylation; SKP1 Cullin F box (SCF) E3 ligase

Indexed keywords

CULLIN; CULLIN RING E3 LIGASE; MAMMALIAN TARGET OF RAPAMYCIN; NEDD8 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; [4 [4 [(2,3 DIHYDRO 1H INDEN 1 YL)AMINO] 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL] 2 HYDROXYCYCLOPENTYLMETHYL] SULFAMATE;

APOPTOSIS; AUTOPHAGY; CANCER INHIBITION; CELL CYCLE ARREST; DRUG MECHANISM; DRUG STRUCTURE; ENZYME DEGRADATION; ENZYME INACTIVATION; NEDDYLATION; SHORT SURVEY; UBIQUITINATION;

EID: 84869414801     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.21484     Document Type: Short Survey

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