Variants of the gentamicin and tobramycin resistance plasmid pRAY are widely distributed in Acinetobacter

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 12, 2012, Pages 2833-2836

  Hamidian, Mohammad ^a   Nigro, Steven J ^a   Hall, Ruth M ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

aadB gene cassettes; Gentamicin resistance; Tobramycin resistance

Indexed keywords

DNA; GENTAMICIN; TOBRAMYCIN;

ACINETOBACTER BAUMANNII; AMPLICON; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BIOINFORMATICS; DNA SEQUENCE; GENE CASSETTE; GENE INSERTION; GENETIC VARIABILITY; MULTILOCUS SEQUENCE TYPING; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; SCREENING;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; AUSTRALIA; BETA-LACTAMASES; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENETIC VARIATION; GENOTYPE; GENTAMICINS; HUMANS; MOLECULAR SEQUENCE DATA; MULTILOCUS SEQUENCE TYPING; PLASMIDS; RESTRICTION MAPPING; SEQUENCE ANALYSIS, DNA; TOBRAMYCIN;

EID: 84869413334     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks318     Document Type: Article

References (11)

1. Cameron FH, Groot Obbink DJ, Ackerman VA et al. Nucleotide sequence of the AAD(2'') aminoglycoside adenyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhrfII in R388. Nucleic Acids Res 1986; 14: 8625-35.
2. Recchia GD, Hall RM. Gene cassettes: a new class of mobile element. Microbiology 1995; 141: 3015-27.
3. Segal H, Elisha BG. Characterization of the Acinetobacter plasmid, pRAY, and the identification of regulatory sequences upstream of an aadB gene cassette on this plasmid. Plasmid 1999; 42: 60-6.
4. Francia MV, Varsaki A, Garcillán-Barcia MP et al. A classification scheme for mobilization regions of bacterial plasmids. FEMS Microbiol Rev 2004; 28: 79-100.
5. Adams MD, Chan ER, Molyneaux ND et al. Genomewide analysis of divergence of antibiotic resistance determinants in closely related isolates of Acinetobacter baumannii. Antimicrob Agents Chemother 2010; 54: 3569-77.
6. Nigro SJ, Post V, Hall RM. Aminoglycoside resistance in multiply antibiotic-resistant Acinetobacter baumannii belonging to global clone 2 from Australian hospitals. J Antimicrob Chemother 2011; 66: 1504-9.
7. Nigro SJ, Post V, Hall RM. The multiresistant Acinetobacter baumannii European clone I type strain RUH875 (A297) carries a genomic antibiotic resistance island AbaR21, plasmid pRAY and a cluster containing ISAba1-sul2-CR2-strB-strA. J Antimicrob Chemother 2011; 66: 1928-30.
8. Hamidian M, Hall RM. AbaR4 replaces AbaR3 in a carbapenem-resistant Acinetobacter baumannii isolate belonging to global clone 1 from an Australian hospital. J Antimicrob Chemother 2011; 66: 2484-91.
9. Post V, Hall RM. AbaR5, a large multiple antibiotic resistance region found in Acinetobacter baumannii. Antimicrob Agents Chemother 2009; 53: 2667-71.
10. Bartual SG, Seifert H, Hippler C et al. Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J Clin Microbiol 2005; 43: 4382-90.
11. Rudant E, Courvalin P, Lambert T. Characterization of IS18, an element capable of activating the silent aac(6')-Ij gene of Acinetobacter sp. 13 strain BM2716 by transposition. Antimicrob Agents Chemother 1998; 42: 2759-61.