Cerebrospinal fluid biochemistry reflects effects of therapeutic hypothermia after cardiac arrest in a porcine model

American Journal of Emergency Medicine

Volumn 30, Issue 8, 2012, Pages 1420-1428

  Hua, Rong ^a   Li, Chunsheng ^a   Gong, Ping ^a   Tang, Ziren ^a   Mei, Xue ^a   Zhao, Hong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; LACTIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN LEVEL; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DISEASE CONTROL; DISEASE MODEL; EXPERIMENTAL ANIMAL; FEVER; HEART ARREST; HEART VENTRICLE FIBRILLATION; INDUCED HYPOTHERMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SWINE; TEMPERATURE MEASUREMENT;

EID: 84869403262     PISSN: 07356757     EISSN: 15328171     Source Type: Journal    
DOI: 10.1016/j.ajem.2011.10.022     Document Type: Article

References (25)

1. Holzer M. Targeted temperature management for comatose survivors of cardiac arrest. N Engl J Med 2010;363:1256-64.
2. Peberdy MA, Callaway CW, Neumar RW, et al. Part 9: post-cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010;122:S768-86.
3. Nielsen N, Friberg H, Gluud C, et al. Hypothermia after cardiac arrest should be further evaluated - a systematic review of randomised trials with meta-analysis and trial sequential analysis. Int J Cardiol 2011; 151:333-41.
4. Takata K, Takeda Y, Sato T, et al. Effects of hypothermia for a short period on histologic outcome and extracellular glutamate concentration during and after cardiac arrest in rats. Crit Care Med 2005;33:1340-5. (Pubitemid 40827387)
5. van Zanten AR, Polderman KH. Early induction of hypothermia: will sooner be better? Crit Care Med 2005;33:1449-52. (Pubitemid 40827418)
6. Nordmark J, Enblad P, Rubertsson S. Cerebral energy failure following experimental cardiac arrest hypothermia treatment reduces secondary lactate/pyruvate-ratio increase. Resuscitation 2009;80:573-9.
7. Arrich J. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007;35:1041-7. (Pubitemid 46598953)
8. Hoedemaekers CW, Ezzahti M, Gerritsen A, et al. Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study. Crit Care 2007;11:R91.
9. Takasu A, Saitoh D, Kaneko N, et al. Hyperthermia: is it an ominous sign after cardiac arrest? Resuscitation 2001;49:273-7. (Pubitemid 32588704)
10. Grund F, Tjomsland O, Sjaastad I, et al. Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine. Lab Anim 2004;38:70-8. (Pubitemid 38117448)
11. Wenzel V, Lindner KH, Krismer AC, et al. Survival with full neurologic recovery and no cerebral pathology after prolonged cardiopulmonary resuscitation with vasopressin in pigs. J Am Coll Cardiol 2000;35:527-33. (Pubitemid 30125548)
12. Hamer AW, Karagueuzian HS, Sugi K, et al. Factors related to the induction of ventricular fibrillation in the normal canine heart by programmed electrical stimulation. J Am Coll Cardiol 1984;3:751-9. (Pubitemid 14166245)
13. Alam HB, Chen Z, Ahuja N, et al. Profound hypothermia protects neurons and astrocytes, and preserves cognitive functions in a Swine model of lethal hemorrhage. J Surg Res 2005;126:172-81. (Pubitemid 40779357)
14. Asai S, Zhao H, Takahashi Y, et al. Minimal effect of brain temperature changes on glutamate release in rat following severe global brain ischemia: a dialysis electrode study. Neuroreport 1998;9: 3863-8. (Pubitemid 29189317)
15. Asai S, Zhao H, Kohno T, et al. Quantitative evaluation of extracellular glutamate concentration in postischemic glutamate re-uptake, dependent on brain temperature, in the rat following severe global brain ischemia. Brain Res 2000;864:60-8. (Pubitemid 30227598)
16. Sharma HS, Miclescu A, Wiklund L. Cardiac arrest-induced regional blood-brain barrier breakdown, edema formation and brain pathology: a light and electron microscopic study on a new model for neurodegeneration and neuroprotection in porcine brain. J Neural Transm 2011;118:87-114.
17. Baena RC, Busto R, Dietrich WD, et al. Hyperthermia delayed by 24 hours aggravates neuronal damage in rat hippocampus following global ischemia. Neurology 1997;48:768-73. (Pubitemid 27120122)
18. Bogaert YE, Rosenthal RE, Fiskum G. Postischemic inhibition of cerebral cortex pyruvate dehydrogenase. Free Radic Biol Med 1994; 16:811-20. (Pubitemid 24193529)
19. Persson L, Hillered L. Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis. J Neurosurg 1992;76: 72-80.
20. Robertson CL, Scafidi S, McKenna MC, et al. Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Exp Neurol 2009;218:371-80.
21. Reinstrup P, Stahl N, Mellergard P, et al. Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery 2000;47: 701-9 [discussion 709-10].
22. Jones AE, Shapiro NI, Trzeciak S, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010;303:739-46.
23. Donnino MW, Miller J, Goyal N, et al. Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients. Resuscitation 2007;75:229-34. (Pubitemid 47588625)
24. Snyder JV, Nemoto EM, Carroll RG, et al. Global ischemia in dogs: intracranial pressures, brain blood flow and metabolism. Stroke 1975;6:21-7.
25. Noguchi K, Matsumoto N, Shiozaki T, et al. Effects of timing and duration of hypothermia on survival in an experimental gerbil model of global ischaemia. Resuscitation 2011;82:481-6