메뉴 건너뛰기




Volumn 17, Issue 11, 2012, Pages 1418-1425

Moderate immunohistochemical expression of her-2 (2) without her-2 gene amplification is a negative prognostic factor in early breast cancer

Author keywords

Breast cancer; Fluorescence in situ hybridization; Her 2; Immunohistochemistry; Prognosis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; HORMONE RECEPTOR; MONOCLONAL ANTIBODY; PROGESTERONE RECEPTOR;

EID: 84869381645     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2012-0194     Document Type: Article
Times cited : (88)

References (30)
  • 2
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-712.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 3
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, Hammond ME, Schwartz JN et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 2007;25:118-145.
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 4
    • 0025781290 scopus 로고
    • Prognostic significance of HER-2/neu expression in breast cancer and its relationship to other prognostic factors
    • Rilke F, Colnaghi MI, Cascinelli N et al. Prognostic significance of HER-2/neu expression in breast cancer and its relationship to other prognostic factors. Int J Cancer 1991;49:44-49.
    • (1991) Int J Cancer , vol.49 , pp. 44-49
    • Rilke, F.1    Colnaghi, M.I.2    Cascinelli, N.3
  • 5
    • 0031684721 scopus 로고    scopus 로고
    • The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy
    • Ross JS, Fletcher JA. The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy. The Oncologist 1998;3:237-252.
    • (1998) The Oncologist , vol.3 , pp. 237-252
    • Ross, J.S.1    Fletcher, J.A.2
  • 6
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 7
    • 0034667952 scopus 로고    scopus 로고
    • HER-2/neu and p53 expression versus tamoxifen resistance in estrogen receptor-positive, node-positive breast cancer
    • Berry DA, Muss HB, Thor AD et al. HER-2/neu and p53 expression versus tamoxifen resistance in estrogen receptor-positive, node-positive breast cancer. J Clin Oncol 2000;18:3471-3479.
    • (2000) J Clin Oncol , vol.18 , pp. 3471-3479
    • Berry, D.A.1    Muss, H.B.2    Thor, A.D.3
  • 8
    • 38049103907 scopus 로고    scopus 로고
    • HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials
    • Gennari A, Sormani MP, Pronzato P et al. HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: A pooled analysis of randomized trials. J Natl Cancer Inst 2008;100:14-20.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 14-20
    • Gennari, A.1    Sormani, M.P.2    Pronzato, P.3
  • 9
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 10
    • 22344446208 scopus 로고    scopus 로고
    • Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
    • Marty M, Cognetti F, Maraninchi D et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 2005;23:4265-4274.
    • (2005) J Clin Oncol , vol.23 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 11
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353:1673-1684.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 12
    • 80052728749 scopus 로고    scopus 로고
    • Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31
    • Perez EA, Romond EH, Suman VJ et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011;29: 3366-3373.
    • (2011) J Clin Oncol , vol.29 , pp. 3366-3373
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 13
    • 79952041937 scopus 로고    scopus 로고
    • Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial
    • Gianni L, Dafni U, Gelber RD et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial. Lancet Oncol 2011;12:236-244.
    • (2011) Lancet Oncol , vol.12 , pp. 236-244
    • Gianni, L.1    Dafni, U.2    Gelber, R.D.3
  • 14
    • 80053539103 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in HER2-positive breast cancer
    • Slamon D, Eiermann W, Robert N et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365:1273-1283.
    • (2011) N Engl J Med , vol.365 , pp. 1273-1283
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 15
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens MA, Horten BC, Da Silva MM. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 2004; 5:63-69.
    • (2004) Clin Breast Cancer , vol.5 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    da Silva, M.M.3
  • 16
    • 0035873962 scopus 로고    scopus 로고
    • Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: Apparent immunohistochemical falsepositives do not get the message
    • Tubbs RR, Pettay JD, Roche PC et al. Discrepancies in clinical laboratory testing of eligibility for trastuzumab therapy: Apparent immunohistochemical falsepositives do not get the message. J Clin Oncol 2001;19: 2714-2721.
    • (2001) J Clin Oncol , vol.19 , pp. 2714-2721
    • Tubbs, R.R.1    Pettay, J.D.2    Roche, P.C.3
  • 17
    • 0042208398 scopus 로고    scopus 로고
    • The Her-2/ neu gene and protein in breast cancer 2003: Biomarker and target of therapy
    • Ross JS, Fletcher JA, Linette GP et al. The Her-2/ neu gene and protein in breast cancer 2003: Biomarker and target of therapy. The Oncologist 2003;8:307-325.
    • (2003) The Oncologist , vol.8 , pp. 307-325
    • Ross, J.S.1    Fletcher, J.A.2    Linette, G.P.3
  • 18
    • 41449105551 scopus 로고    scopus 로고
    • HER2 status and benefit from adjuvant trastuzumab in breast cancer
    • Paik S, Kim C, Wolmark N. HER2 status and benefit from adjuvant trastuzumab in breast cancer. N Engl J Med 2008;358:1409-1411.
    • (2008) N Engl J Med , vol.358 , pp. 1409-1411
    • Paik, S.1    Kim, C.2    Wolmark, N.3
  • 19
    • 78049431141 scopus 로고    scopus 로고
    • HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial
    • Perez EA, Reinholz MM, Hillman DW et al. HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial. J Clin Oncol 2010;28: 4307-4315.
    • (2010) J Clin Oncol , vol.28 , pp. 4307-4315
    • Perez, E.A.1    Reinholz, M.M.2    Hillman, D.W.3
  • 20
    • 84870960364 scopus 로고    scopus 로고
    • Available at, accessed June 10, 2012
    • National Surgical Breast and Bowel Project trial 2012;47. Available at http://www.nsabp.pitt.edu/B-47.asp, accessed June 10, 2012.
    • (2012) National Surgical Breast and Bowel Project trial , vol.47
  • 21
    • 0032443067 scopus 로고    scopus 로고
    • Time-dependence of hazard ratios for prognostic factors in primary breast cancer
    • Hilsenbeck SG, Ravdin PM, de Moor CA et al. Time-dependence of hazard ratios for prognostic factors in primary breast cancer. Breast Cancer Res Treat 1998; 52:227-237.
    • (1998) Breast Cancer Res Treat , vol.52 , pp. 227-237
    • Hilsenbeck, S.G.1    Ravdin, P.M.2    de Moor, C.A.3
  • 22
    • 66849140730 scopus 로고    scopus 로고
    • Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer
    • Cheang MC, Chia SK, Voduc D et al. Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 2009;101:736-750.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 736-750
    • Cheang, M.C.1    Chia, S.K.2    Voduc, D.3
  • 23
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sr-lie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 2000;406:747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sr-Lie, T.2    Eisen, M.B.3
  • 24
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Srrlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-10874.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10869-10874
    • Srrlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 25
    • 18244422222 scopus 로고    scopus 로고
    • HER-2/neu gene amplification characterized by fluorescence in situ hybridization: Poor prognosis in node-negative breast carcinomas
    • Press MF, Bernstein L, Thomas PA et al. HER-2/neu gene amplification characterized by fluorescence in situ hybridization: Poor prognosis in node-negative breast carcinomas. J Clin Oncol 1997;15:2894-2904.
    • (1997) J Clin Oncol , vol.15 , pp. 2894-2904
    • Press, M.F.1    Bernstein, L.2    Thomas, P.A.3
  • 26
    • 0034900183 scopus 로고    scopus 로고
    • Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer
    • Birner P, Oberhuber G, Stani J et al. Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer. Clin Cancer Res 2001;7:1669-1675.
    • (2001) Clin Cancer Res , vol.7 , pp. 1669-1675
    • Birner, P.1    Oberhuber, G.2    Stani, J.3
  • 27
    • 53049084124 scopus 로고    scopus 로고
    • Biology, prognosis and response to therapy of breast carcinomas according to HER2 score
    • Ménard S, Balsari A, Tagliabue E et al. Biology, prognosis and response to therapy of breast carcinomas according to HER2 score. Ann Oncol 2008;19:1706-1712.
    • (2008) Ann Oncol , vol.19 , pp. 1706-1712
    • Ménard, S.1    Balsari, A.2    Tagliabue, E.3
  • 28
    • 65449173170 scopus 로고    scopus 로고
    • Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer
    • Gilcrease MZ, Woodward WA, Nicolas MM et al. Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer. Am J Surg Pathol 2009;33:759-767.
    • (2009) Am J Surg Pathol , vol.33 , pp. 759-767
    • Gilcrease, M.Z.1    Woodward, W.A.2    Nicolas, M.M.3
  • 29
    • 77649108628 scopus 로고    scopus 로고
    • Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer
    • Minner S, Jessen B, Stiedenroth L et al. Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer. Clin Cancer Res 2010;16:1553-1560.
    • (2010) Clin Cancer Res , vol.16 , pp. 1553-1560
    • Minner, S.1    Jessen, B.2    Stiedenroth, L.3
  • 30
    • 38849154186 scopus 로고    scopus 로고
    • HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas
    • Engelsen IB, Stefansson IM, Beroukhim R et al. HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas. Int J Oncol 2008;32:307-316.
    • (2008) Int J Oncol , vol.32 , pp. 307-316
    • Engelsen, I.B.1    Stefansson, I.M.2    Beroukhim, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.