Novel biological strategies in the management of anal fistula

Colorectal Disease

Volumn 14, Issue 12, 2012, Pages 1445-1455

  Lewis, R ^a   Lunniss, P J ^a,b   Hammond, T M ^c  

^a HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c ST MARK S HOSPITAL   (United Kingdom)

Author keywords

Anal fistula; Biomaterial; Fistula in ano; Glue; Implant; Plug

Indexed keywords

BIOMATERIAL; CYANOACRYLATE; CYTOKINE; FIBRIN GLUE; FIBROBLAST GROWTH FACTOR 2; GLUTARALDEHYDE; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; GROWTH FACTOR; LIPID; MICROSPHERE; PROTEOGLYCAN; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; TISSUE ADHESIVE;

ACELLULAR DERMAL MATRIX; ADIPOSE DERIVED STEM CELL; ALLOGRAFT; ANUS FISTULA; BIOCOMPATIBILITY; CLINICAL EFFECTIVENESS; ENZYMATIC DEGRADATION; HUMAN; IMMUNE RESPONSE; IMPLANT; INFLAMMATION; INTESTINE PREPARATION; MESENCHYMAL STROMA CELL; META ANALYSIS; NONHUMAN; PATIENT SAFETY; PERIANAL ABSCESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECTOVAGINAL FISTULA; REVIEW; SMALL INTESTINE MUCOSA; STEM CELL TRANSPLANTATION; SYSTEMATIC REVIEW; TISSUE REGENERATION; WOUND CARE; WOUND HEALING; XENOGRAFT;

ACELLULAR DERMIS; ANAL CANAL; ANIMALS; BIOCOMPATIBLE MATERIALS; CYANOACRYLATES; CYTOKINES; EXTRACELLULAR MATRIX; HUMANS; MICROSPHERES; ORGAN SPARING TREATMENTS; PROTEINS; RECTAL FISTULA; STEM CELL TRANSPLANTATION;

EID: 84869235557     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2012.03192.x     Document Type: Review

References (72)

1. Ellis CN. Sphincter-preserving fistula management: what patients want. Dis Colon Rectum 2010; 53: 1652-5.
2. Lunniss PJ, Kamm MA, Phillips RK. Factors affecting continence after surgery for anal fistula. Br J Surg 1994; 81: 1382-5.
3. Garcia-Aguilar J, Davey CS, Le CT, Lowry AC, Rothenberger DA. Patient satisfaction after surgical treatment for fistula-in-ano. Dis Colon Rectum 2000; 43: 1206-12.
4. Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD. Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum 1996; 39: 723-9.
5. Buchanan GN, Bartram CI, Phillips RK et al. Efficacy of fibrin sealant in the management of complex anal fistula: a prospective trial. Dis Colon Rectum 2003; 46: 1167-74.
6. Lunniss PJ. The role of the advancement flap technique. Semin Colon Rectal Surg 1998; 9: 192-7.
7. Soltani A, Kaiser AM. Endorectal Advancement Flap for Cryptoglandular or Crohn's Fistula-in-Ano. Dis Colon Rectum 2010; 53: 486-95.
8. Dudukgian H, Abcarian H. Why do we have so much trouble treating anal fistula?World J Gastroenterol 2011; 17: 3292-6.
9. Shawki S, Wexner SD. Idiopathic fistula-in-ano. World J Gastroenterol 2011; 17: 3277-85.
10. van Onkelen RS, Gosselink MP, Schouten WR. Is it possible to improve the outcome of transanal advancement flap repair for high transsphincteric fistulas by additional ligation of the intersphincteric fistula tract?Dis Colon Rectum 2012; 55: 163-6.
11. Ellis CN. Outcomes with the use of bioprosthetic grafts to reinforce the ligation of the intersphincteric fistula tract (BioLIFT procedure) for the management of complex anal fistulas. Dis Colon Rectum 2010; 53: 1361-4.
12. Himpson RC, Cohen CRG, Sibbons P, Phillips RKS. Histological evidence for enhanced anal fistula repair using autologous fibroblasts in a dermal collagen matrix. Comp Clin Pathol 2007; 16: 9-14.
13. Hammond TM, Porrett TR, Scott SM, Williams NS, Lunniss PJ. Management of idiopathic anal fistula using cross-linked collagen: a prospective phase 1 study. Colorectal Dis 2011; 13: 94-104.
14. Gullà N, Boselli C, Avenia N, Sciannameo F, Basoli A. Meta-analysis of fibrin glue versus surgery for treatment of fistula-in-ano. Ann Ital Chir 2010; 81: 349-56.
15. Jacob TJ, Perakath B, Keighley MR. Surgical intervention for anorectal fistula. Cochrane Database Syst Rev 2010; CD006319.
16. Garg P, Song J, Bhatia A, Kalia H, Menon GR. The efficacy of anal fistula plug in fistula-in-ano: a systematic review. Colorectal Dis 2010; 12: 965-70.
17. Hammond TM, Grahn MF, Lunniss PJ. Fibrin glue in the management of anal fistulae. Colorectal Dis 2004; 6: 308-19.
18. Amrani S, Zimmern A, O'Hara K, Corman ML. The Surgisis AFP anal fistula plug: a new and reasonable alternative for the treatment of anal fistula. Gastroenterol Clin Biol 2008; 32: 946-8.
19. Mitalas LE, van Onkelen RS, Gosselink MP, Zimmerman DD, Schouten WR. The anal fistula plug as an adjunct to transanal advancement flap repair. Dis Colon Rectum 2010; 53: 1713.
20. van Koperen PJ, Wind J, Bemelman WA, Slors JF. Fibrin glue and transanal rectal advancement flap for high transsphincteric perianal fistulas; is there any advantage?Int J Colorectal Dis 2008; 23: 697-701.
21. Liberati A, Altman DG, Tetzlaff J et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009; 6: e1000100.
22. Peppas NA, Langer R. New challenges in biomaterials. Science 1994; 263: 1715-20.
23. Hadorn DC, Baker D, Hodges JS, Hicks N. Rating the quality of evidence for clinical practice guidelines. J Clin Epidemiol 1996; 49: 749-54.
24. Song WL, Wang ZJ, Zheng Y, Yang XQ, Peng YP. An anorectal fistula treatment with acellular extracellular matrix: a new technique. World J Gastroenterol 2008; 14: 4791-4.
25. A ba-bai-ke-re MM, Wen H, Huang HG et al. Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for complex anorectal fistula. World J Gastroenterol 2010; 16: 3279-86.
26. de la Portilla F, Rada R, Leon E et al. Evaluation of the use of BioGlueA in the treatment of high anal fistulas: preliminary results of a pilot study. Dis Colon Rectum 2007; 50: 218-22.
27. García-Olmo D, Herreros D, De-La-Quintana P et al. Adipose-derived stem cells in Crohn's rectovaginal fistula. Case Report Med 2010; 2010: 961758.
28. García-Olmo D, García-Arranz M, Herreros D, Pascual I, Peiro C, Rodríguez-Montes JA. A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 2005; 48: 1416-23.
29. Garcia-Olmo D, Herreros D, Pascual I et al. Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum 2009; 52: 79-86.
30. García-Olmo D, García-Arranz M, García LG et al. Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy. Int J Colorectal Dis 2003; 18: 451-4.
31. de la Portilla F, Rada R, Vega J, Cisneros N, Maldonado VH, Sánchez-Gil JM. Long-term results change conclusions on BioGlue in the treatment of high transsphincteric anal fistulas. Dis Colon Rectum 2010; 53: 1220-1.
32. Guadalajara H, Herreros D, De-La-Quintana P, Trebol J, Garcia-Arranz M, Garcia-Olmo D. Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas. Int J Colorectal Dis 2012; 27: 595-600.
33. Queralto M, Portier G, Bonnaud G, Chotard JP, Cabarrot P, Lazorthes F. Efficacy of synthetic glue treatment of high crypoglandular fistula-in-ano. Gastroenterol Clin Biol 2010; 34: 477-82.
34. Jain SK, Kaza RC, Pahwa M, Bansal S. Role of cyanoacrylate in the management of low fistula in ano: a prospective study. Int J Colorectal Dis 2008; 23: 355-8.
35. Barillari P, Basso L, Larcinese A, Gozzo P, Indinnimeo M. Cyanoacrylate glue in the treatment of ano-rectal fistulas. Int J Colorectal Dis 2006; 21: 791-4.
36. Fortelny RH, Petter-Puchner AH, Walder N et al. Cyanoacrylate tissue sealant impairs tissue integration of macroporous mesh in experimental hernia repair. Surg Endosc 2007; 21: 1781-5.
37. Meinero P, Mori L. Video-assisted anal fistula treatment (VAAFT): a novel sphincter-saving procedure for treating complex anal fistulas. Tech Coloproctol 2011; 15: 417-22.
38. Katz AR, Mukherjee DP, Kaganov AL, Gordon S. A new synthetic monofilament absorbable suture made from polytrimethylene carbonate. Surg Gynecol Obstet 1985; 161: 213-22.
39. http://www.goremedical.com/fistulaplug/documents; accessed 4 December 2011.
40. de la Portilla F, Rada R, Jiménez-Rodríguez R, Díaz-Pavón JM, Sánchez-Gil JM. Evaluation of a new synthetic plug in the treatment of anal fistulas: results of a pilot study. Dis Colon Rectum 2011; 54: 1419-22.
41. Buchberg B, Masoomi H, Choi J, Bergman H, Mills S, Stamos MJ. A tale of two (anal fistula) plugs: is there a difference in short-term outcomes?Am Surg 2010; 76: 1150-3.
42. Ratto C, Litta F, Parello A, Donisi L, Zacone G, De Simone V. Gore Bio A® Fistula Plug, a new sphincter-sparing procedure for complex anal fistula. Colorectal Dis 2012; 14: e264-9.
43. Foong KS, Patel R, Forbes A, Day RM. Anti-tumor necrosis factor-alpha-loaded microspheres as a prospective novel treatment for Crohn's disease fistulae. Tissue Eng Part C Methods 2010; 16: 855-64.
44. Blaker JJ, Pratten J, Ready D, Knowles JC, Forbes A, Day RM. Assessment of antimicrobial microspheres as a prospective novel treatment targeted towards the repair of perianal fistulae. Aliment Pharmacol Ther 2008; 28: 614-22.
45. Hammond TM, Chin-Aleong J, Navsaria H, Williams NS. Human in vivo cellular response to a cross-linked acellular collagen implant. Br J Surg 2008; 95: 438-46.
46. http://www.cryolife.com/products/bioglue-surgical-adhesive; accessed 4 December 2011.
47. Alexander SM, Mitalas LE, Gosselink MP, Oom DM, Zimmerman DD, Schouten WR. Obliteration of the fistulous tract with BioGlue adversely affects the outcome of transanal advancement flap repair. Tech Coloproctol 2008; 12: 225-8.
48. Abbas MA, Tejirian T. Bioglue for the treatment of anal fistula is associated with acute anal sepsis. Dis Colon Rectum 2008; 51: 1155.
49. Keshaw H, Foong KS, Forbes A, Day RM. Perianal fistulae in Crohn's Disease: current and future approaches to treatment. Inflamm Bowel Dis 2010; 16: 870-80.
50. Bellows CF, Alder A, Helton WS. Abdominal wall reconstruction using biological tissue grafts: present status and future opportunities. Expert Rev Med Devices 2006; 3: 657-75.
51. Han JG, Xu HM, Song WL et al. Histologic analysis of acellular dermal matrix in the treatment of anal fistula in an animal model. J Am Coll Surg 2009; 208: 1099-106.
52. Silverman RP, Li EN, Holton LH III, Sawan KT, Goldberg NH. Ventral hernia repair using allogenic acellular dermal matrix in a swine model. Hernia 2004; 8: 336-42.
53. Han JG, Wang ZJ, Zhao BC et al. Long-term outcomes of human acellular dermal matrix plug in closure of complex anal fistulas with a single tract. Dis Colon Rectum 2011; 54: 1412-8.
54. Miklos JR, Kohli N. Rectovaginal fistula repair utilizing a cadaveric dermal allograft. Int Urogynecol J Pelvic Floor Dysfunct 1999; 10: 405-6.
55. Shelton AA, Welton ML. Transperineal repair of persistent rectovaginal fistulas using an acellular cadaveric dermal graft (AlloDerm). Dis Colon Rectum 2006; 49: 1454-7.
56. Ge L, Zheng S, Wei H. Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM. Burns 2009; 35: 46-50.
57. Hodde J. Extracellular matrix as a bioactive material for soft tissue reconstruction. ANZ J Surg 2006; 76: 1096-100.
58. Soiderer EE, Lantz GC, Kazacos EA, Hodde JP, Wiegand RE. Morphologic study of three collagen materials for body wall repair. J Surg Res 2004; 118: 161-75.
59. Ellis CN. Outcomes after repair of rectovaginal fistulas using bioprosthetics. Dis Colon Rectum 2008; 51: 1084-8.
60. Schwandner O, Fuerst A, Kunstreich K, Scherer R. Innovative technique for the closure of rectovaginal fistula using Surgisis mesh. Tech Coloproctol 2009; 13: 135-40.
61. Schwandner O, Fuerst A. Preliminary results on efficacy in closure of transsphincteric and rectovaginal fistulas associated with Crohn's disease using new biomaterials. Surg Innov 2009; 16: 162-8.
62. Shevchenko RV, Sibbons PD, Sharpe JR, James SE. Use of a novel porcine collagen paste as a dermal substitute in full thickness wounds. Wound Repair Regen 2008; 16: 198-207.
63. Sileri P, Franceschilli L, Del Vecchio Blanco G, Stolfi VM, Angelucci GP, Gaspari AL. Porcine dermal collagen matrix injection may enhance flap repair surgery for complex anal fistula. Int J Colorectal Dis 2011; 26: 345-9.
64. Himpson RC, Cohen CR, Sibbons P, Phillips RK. An experimentally successful new sphincter-conserving treatment for anal fistula. Dis Colon Rectum 2009; 52: 602-8.
65. Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol 2002; 13: 377-83.
66. Kubota M, Hirayama Y, Okuyama N. Usefulness of bFGF spray in the treatment of perianal abscess and fistula-in-ano. Pediatr Surg Int 2010; 26: 1037-40.
67. Ge BJ, Guo SM. Curative effects of basic fibroblast growth factor on anus wound healing. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2002; 16: 345-7.
68. Ascanelli S, de Tullio D, Gregorio C, Azzena G, Occhionorelli S. Autologous fibroblasts transplant after infliximab administration: a new approach in Crohn's perianal fistulas? Brief clinical report. Int J Colorectal Dis 2007; 22: 1135-6.
69. Ciccocioppo R, Bernardo ME, Sgarella A et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 2011; 60: 788-98.
70. Esmaeili M, Najarian S, Kashani SM. A novel device for minimally invasive 'core-out' fistulectomy of high fistula-in-ano. J Med Eng Technol 2012; 36: 67-71.
71. Tasci I. The fistulectome: a new device for treatment of complex anal fistulae by ''Core-Out'' fistulectomy. Dis Colon Rectum 2003; 46: 1566-71.
72. http://www.controlled-trials.com/ISRCTN78352529; accessed 5 June 2012.